Plasmodium falciparum parasite.
Research is continually revealing just how efficient the human malaria parasite, Plasmodium falciparum, is at making people sick — and, all too often, killing them. There can be few better examples of the sort of intricate, information-rich biological machinery that Discovery Institute Fellows such as Michael J. Behe and William A. Dembski insist points to an intelligent designer. Although they are careful never to say so plainly, their dog-whistle signals leave their followers in little doubt that this putative designer is meant to be the god of the Bible and Qur’an. That ambiguity gives them enough wriggle-room to tell courts and educators that Intelligent Design is science, not creationism in a lab coat, while still presenting it to supporters as a moral crusade against “Darwinism”.
Now researchers at the Weizmann Institute of Science, in a paper published recently in Cell Reports, have shown yet another reason why this parasite is so successful. Malaria caused an estimated 610,000 deaths in 2024; the WHO African Region accounted for about 95% of those deaths, and children under five made up about three-quarters of the deaths in that region, according to the World Health Organization.
The researchers, led by Professor Neta Regev-Rudzki, discovered that the parasite exports tiny vesicles containing messenger RNA (mRNA), not only into the red blood cells it infects, but also into the host’s monocytes — immune-system cells that should be helping to fight the infection. Once inside the monocyte, the parasite’s mRNA enters the cell nucleus and binds to two essential human proteins, ACIN1 and PNN, which are normally involved in cutting and splicing RNA transcripts so they can be translated into proteins. With this splicing machinery disrupted, crucial immune-related transcripts are misprocessed and degraded, suppressing the production of proteins needed for an effective immune response.
In other words, P. falciparum is not merely hiding from the immune system; it is actively sabotaging part of the host’s cellular communication network from inside the nucleus. The result is a neat evolutionary trick: the immune system is distracted and disrupted while the real threat — parasites multiplying inside red blood cells — continues to spread.