Wild koala, Phascolarctos cinereus
© A. Gillet
Intelligent [sic] Design Creationists are stuck with a dogma that denies the role of amoral, purposeless natural forces in nature and must ascribe everything to the deliberate intent of a magic deity, whom they equate to the supposedly all-loving god of the Bible.
This means of course that the devastation the koalas are suffering right now is the result of this putative magic designer's intention. As the press release from the Leibniz Institute for Zoo and Wildlife Research, Berlin, Germany, reports:
Koalas are facing multiple environmental and health issues which threaten their survival. Along with habitat loss - accelerated by last year’s devastating bush fires – domestic dog attacks and road accidents, they suffer from deadly chlamydial infections and extremely high frequency of cancer. An international team of scientists led by the Leibniz Institute for Zoo and Wildlife Research (Leibniz-IZW) now demonstrate that a retrovirus invading the koala germline explains the high frequency of koala cancer. The results are reported in the journal Nature Communications.
Each koala carries around 80 - 100 inherited copies of KoRV in its genome. The genomic locations of most of these are not shared between koalas, indicating a rapid expansion and accumulation of KoRV copies in the population. Each time a retrovirus copies and re-inserts itself into the genome, it causes a mutation, potentially disrupting gene expression, which could be detrimental to the host.
In summary then, we find multiple links at the genomic level between cancer-related genes and KoRV, revealing ways in which KoRV underlies the high frequency of cancer in koalas.
Prof Alex Greenwood
Head of Department of Wildlife Diseases
Leibniz-IZW
Head of Department of Wildlife Diseases
Leibniz-IZW
In summary then, we find multiple links at the genomic level between cancer-related genes and KoRV, revealing ways in which KoRV underlies the high frequency of cancer in koalas.
Gayle McEwen
Scientist at Leibniz-IZW.
Scientist at Leibniz-IZW.
The koala retrovirus (KoRV) is a virus which, like other retroviruses such as HIV, inserts itself into the DNA of an infected cell. At some point in the past 50,000 years, KoRV has infected the egg or sperm cells of koalas, leading to offspring that carry the retrovirus in every cell in their body. The entire koala population of Queensland and New South Wales in Australia now carry copies of KoRV in their genome. All animals, including humans, have gone through similar “germ line” infections by retroviruses at some point in their evolutionary history and contain many ancient retroviruses in their genomes. These retroviruses have, over millions of years, mutated into degraded, inactive forms that are no longer harmful to the host. Since in most animal species this process occurred millions of years ago, the immediate health effects on the host at that time are unknown but it has been suspected for some time that the invasion of a genome by a retrovirus may have considerable detrimental health effects. The koala is at a very early stage of this process when the retrovirus is still active and these health effects can be studied.
Since retroviruses can cause cancer, it was thought that there is a link between KoRV and the high frequency of lymphoma, leukemia and other cancers in koalas from northern Australia. To investigate this link, scientists at the Leibniz-IZW sequenced DNA from wild koalas suffering from cancer. This allowed them to accurately detect the number of copies of KoRV in the koala genomes and identify the precise locations where the retrovirus had inserted its DNA. By comparing this information between healthy and tumour tissues in single koalas, and by comparing insertion sites between koala individuals, they found multiple links between KoRV and genes known to be involved in the kind of cancers to which koalas are prone.
“Each koala carries around 80 - 100 inherited copies of KoRV in its genome. The genomic locations of most of these are not shared between koalas, indicating a rapid expansion and accumulation of KoRV copies in the population. Each time a retrovirus copies and re-inserts itself into the genome, it causes a mutation, potentially disrupting gene expression, which could be detrimental to the host,” says Prof Alex Greenwood, Head of Department of Wildlife Diseases at the Leibniz-IZW. This means that by frequently copying itself to new locations in the genome, KoRV is currently conferring a high mutational load on the koala population. Tumour tissues contain many new copies of KoRV, indicating that KoRV is more active in tumour cells. These copies generally were located close to genes associated with cancer. New KoRV insertions in tumour tissues affected the expression of genes in their vicinity. Such changes in gene expression associated with cancer can cause increased cell growth and proliferation, which leads to tumours. Although other factors may also contribute to cancer in koalas, the mutational burden from KoRV likely increases the frequency of cells becoming cancerous and may shorten the time for cancer to develop.
In one koala, a copy of KoRV was found that had incorporated an entire cancer-related gene from the koala genome into its DNA sequence. This greatly increased expression of this gene and most likely caused cancer in this particular koala. If this mutated virus is transmissible, it would be of grave concern for koala conservation efforts. Comparing the genomic location of KoRVs between koalas also suggests that KoRV may predispose related koalas to particular tumours, with koalas sharing KoRV insertions in specific cancer-related genes suffering from similar types of cancer which they can pass on to their offspring. Across all koalas studied, there were “hot spots” in the genome where KoRV frequently inserts itself. These hot spots were also located in proximity to genes associated with cancer. “In summary then, we find multiple links at the genomic level between cancer-related genes and KoRV, revealing ways in which KoRV underlies the high frequency of cancer in koalas,” explains Gayle McEwen, scientist at the Leibniz-IZW.
The results highlight the detrimental health consequences that wildlife species can suffer following germline infection by retroviruses. Germline invasions have been repeatedly experienced during vertebrate evolution and have shaped vertebrate genomes, including the lineage leading to modern humans. These were most likely associated with severe detrimental health effects, which must be endured and overcome to ensure species survival. The scientists at the Leibniz-IZW have previously shown that old retroviruses present in the koala genome aid the rapid degradation of KoRV. The koala finds itself in a race to survive the effects of KoRV long enough for the virus to be degraded. Considering the many threats to koalas, it is a race they need to win.
Abstract
Repeated retroviral infections of vertebrate germlines have made endogenous retroviruses ubiquitous features of mammalian genomes. However, millions of years of evolution obscure many of the immediate repercussions of retroviral endogenisation on host health. Here we examine retroviral endogenisation during its earliest stages in the koala (Phascolarctos cinereus), a species undergoing germline invasion by koala retrovirus (KoRV) and affected by high cancer prevalence. We characterise KoRV integration sites (IS) in tumour and healthy tissues from 10 koalas, detecting 1002 unique IS, with hotspots of integration occurring in the vicinity of known cancer genes. We find that tumours accumulate novel IS, with proximate genes over-represented for cancer associations. We detect dysregulation of genes containing IS and identify a highly-expressed transduced oncogene. Our data provide insights into the tremendous mutational load suffered by the host during active retroviral germline invasion, a process repeatedly experienced and overcome during the evolution of vertebrate lineages.
McEwen, Gayle K.; Alquezar-Planas, David E.; Dayaram, Anisha; Gillett, Amber; Tarlinton, Rachael; Mongan, Nigel; Chappell, Keith J.; Henning, Joerg; Tan, Milton; Timms, Peter; Young, Paul R.; Roca, Alfred L.; Greenwood, Alex D.
Retroviral integrations contribute to elevated host cancer rates during germline invasion
Nature Communications 12, 1316 (2021). doi: 10.1038/s41467-021-21612-7
Copyright: © 2021 The authors. Published by Springer Nature Ltd.
Open access
Reprinted under a Creative Commons Attribution 4.0 International License (CC BY 4.0)
Retroviral integrations contribute to elevated host cancer rates during germline invasion
Nature Communications 12, 1316 (2021). doi: 10.1038/s41467-021-21612-7
Copyright: © 2021 The authors. Published by Springer Nature Ltd.Open access
Reprinted under a Creative Commons Attribution 4.0 International License (CC BY 4.0)
Since creationists normally abandon the pretence that the Intelligent [sic] Design notion is real science and resort to Christian fundamentalism by invoking 'The Fall' at this point in the debate, I'm tempted to ask what they think the ancestral koalas did to offend their god since they don't even eat apples, and whether they need to be baptized and accept Jesus as their personal saviour to be rid of this cancer, but maybe their malevolent god just enjoys watching its creation suffer, or hasn't thought of a good way of telling them what they need to do yet.
The results of the research are published open access in the journal Nature Communications.
By the way, did anyone spot any sign that the Theory of Evolution is a theory in crisis and about to be overthrown by the religious dogma of Intelligent [sic] Design, or any other form of religious superstition in that article and the associated research paper?
Me neither! Another false prophesy from another false prophet?
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