Malevolent Design News
Creationism's Divine Malevolence is Hopelessly Muddled
Creationism's Divine Malevolence is Hopelessly Muddled
Human Coronavirus OC43
Although Creationists can be proud of their divine malevolence's triumph with its SARS-CoV-2 virus and the pandemic it caused, scientists have discovered that it wasn't as clever as Creationists like to imagine.
Apart from having to design the virus to overcome the defences it designed to protect us from the viruses it creates to harm up, if you follow me, it then has to continually modify its design to overcome the defences human medical science devises, such as vaccines (which only work because we have those defences in the first place, no matter how inadequate). It is as though Creationism's supposedly omniscient, omnipotent designer doesn't have a clue about the future and can only respond when it happens.
And, like a true amnesiac, it seems to forget entirely what it designed yesterday, and why it designed it, so it ends up in a pointless and wasteful arms race with itself; continually designing solutions today to the solutions it designed yesterday which it now thinks are new problems to be solved.
And now we learn from a study by researchers at Sweden's Karolinska Institutet that infection by one of its earlier designs, the OC43 corona virus which causes the common cold, produces antibodies that give some protection against its SARS-CoV-2 coronavirus!
Page from the parish register of burials for Leafield, Oxfordshire, UK, 1837.
(Note the number of 'infant', child and young adult burials).
(Note the number of 'infant', child and young adult burials).
Source: Ancestry.co.uk
COVID is something of an anomaly since the malevolent designer's pathogens are normally more effective against children, hence the very high infant mortality rates before medical science developed vaccines to protect them. Up to the late 19th century, funeral were vastly more common for children under 5 years-old than for adults, as can be seen in any parish register.
As the news release from the Karolinska Institute explains:
During the pandemic, it became clear that children who contracted COVID-19 became less ill than adults. One hypothesis has been that common colds would give children immunity protecting against a severe form of the disease. Researchers at Karolinska Institutet are now able to show that OC43, one of the coronaviruses that cause common colds, boosts the immune response to COVID-19. The study, which is published in PNAS, could give rise to more tailored vaccine programmes for children and adults.
During the pandemic, medical doctors and researchers noticed that children and adolescents infected with COVID-19 became less ill than adults. A possible explanation for this is that children already had a prior level of immunity to COVID-19 provided by memory T cells generated by common colds.
After studying unique blood samples from children taken before the pandemic, researchers from Karolinska Institutet in Sweden have now identified memory T cells that react to cells infected with SARS-CoV-2, the virus that causes COVID-19.
Four coronaviruses cause common colds
A possible explanation for this immunity in children is that they already had colds caused by one of the four coronaviruses causing seasonal common cold symptoms. This could stimulate an immune response with T cells able to also react to cells infected with SARS-CoV-2.
This new study reinforces this hypothesis and shows that T cells previously activated by the OC43 virus can cross-react against SARS-CoV-2.
These reactions are especially strong early in life and grow much weaker as we get older. Our findings show how the T-cell response develops and changes over time and can guide the future monitoring and development of vaccines.
Annika Karlsson, corresponding author
Research group leader
Department of Laboratory Medicine
Karolinska Institutet, Stockholm, Sweden.Strong immunity at the age of twoNext, we’d like to do analogous studies of younger and older children, teenagers and young adults to better track how the immune response to coronaviruses develops from childhood to adulthood.
Dr Marion Humbert, joint first author
Department of Medicine Huddinge
Karolinska Institutet, Stockholm, Sweden.
The results indicate that the memory T-cell response to coronaviruses develops as early as the age of two. The study was based on 48 blood samples from two- and six-year-old children, and 94 samples from adults between the ages of 26 and 83. The analysis also included blood samples from 58 people who had recently recovered from COVID-19.
The team's open access paper in PNAS gives more detail:
SignificanceIt looks then, as though Creationism's divine malevolence blundered in not remembering what it created children's immune system for and how it works, or, for some reason, it changed the habit of a lifetime and stopped targeting its nasty little pathogens especially at children. Spectacular though its success has been with the SARS-CoV-2 virus, it could have done much better if it had just paid a little more attention to detail and had remembered how its target marks were designed.
Our results provide evidence that functional pre-existing SARS-CoV-2-reactive memory CD4+ T cells are elicited in early childhood and linked to seroconversion with the seasonal coronavirus OC43 but not many other viral infections. Compared to other viruses, the high OC43 seroprevalence at age two indicates that memory responses to coronaviruses develop at a young age. The distinct age-dependent profiles of the responding T cells suggest that cross-reactive T cells can contribute to the different clinical outcomes of COVID-19 in children and the elderly. The present results provide important advances regarding antigen-specific memory CD4+ T cell development and maturation, which can help guide future vaccine and therapeutic interventions relating to specificity, function, and phenotype of memory T cell responses throughout the human life span.
Abstract
Pre-existing SARS-CoV-2-reactive T cells have been identified in SARS-CoV-2-unexposed individuals, potentially modulating COVID-19 and vaccination outcomes. Here, we provide evidence that functional cross-reactive memory CD4+ T cell immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is established in early childhood, mirroring early seroconversion with seasonal human coronavirus OC43. Humoral and cellular immune responses against OC43 and SARS-CoV-2 were assessed in SARS-CoV-2-unexposed children (paired samples at age two and six) and adults (age 26 to 83). Pre-existing SARS-CoV-2-reactive CD4+ T cell responses targeting spike, nucleocapsid, and membrane were closely linked to the frequency of OC43-specific memory CD4+ T cells in childhood. The functional quality of the cross-reactive memory CD4+ T cell responses targeting SARS-CoV-2 spike, but not nucleocapsid, paralleled OC43-specific T cell responses. OC43-specific antibodies were prevalent already at age two. However, they did not increase further with age, contrasting with the antibody magnitudes against HKU1 (β-coronavirus), 229E and NL63 (α-coronaviruses), rhinovirus, Epstein–Barr virus (EBV), and influenza virus, which increased after age two. The quality of the memory CD4+ T cell responses peaked at age six and subsequently declined with age, with diminished expression of interferon (IFN)-γ, interleukin (IL)-2, tumor necrosis factor (TNF), and CD38 in late adulthood. Age-dependent qualitative differences in the pre-existing SARS-CoV-2-reactive T cell responses may reflect the ability of the host to control coronavirus infections and respond to vaccination.
Humbert, Marion; Olofsson, Anna; Wullimann, David; Niessl, Julia; Hodcroft, Emma B.; Cai, Curtis; Gao, Yu; Sohlberg, Ebba; Dyrdak, Robert; Mikaeloff, Flora; Neogi, Ujjwal; Albert, Jan; Malmberg, Karl-Johan; Lund-Johansen, Fridtjof; Aleman, Soo; Björkhem-Bergman, Linda ; Jenmalm, Maria C.; Ljunggren, Hans-Gustaf; Buggert, Marcus; Karlsson, Annika C.
Functional SARS-CoV-2 cross-reactive CD4+ T cells established in early childhood decline with age
Proceedings of the National Academy of Sciences, 120(12) e2220320120. doi: 10.1073/pnas.2220320120.
Copyright: © 2023 The authors.
Published by PNAS Open access.
Reprinted under a Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND 4.0).
Imagine the mental gymnastics and intellectual bankruptcy needed to believe that, rather than accept that viruses and our immune systems are the product of an amoral, unthinking, utilitarian natural process in which neither magic nor magicians were involved.
And what a hideous mindset that believes anything that could create these pathogens and design such badly designed systems is worthy of adoration and worship!
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