Malevolent Designer News - How Bacterial Pathogens Are Cleverly Designed to Invade Their Victim's Body

The exceptional secretion mechanism of Tc Toxins.

MPI MOPH

Functional model for Yen-Tc toxicity. Following ingestion of the Tc, it is likely that the surface-bound chitinases bind to and/or degrade the chitin-rich peritrophic membrane of the insect midgut. Cell surface recognition is likely facilitated by motifs within the A subunits prior to internalization. Similarities to the well characterized bacterial binary toxin systems (e.g., anthrax, cholera, diphtheria) suggest a mechanism involving receptor-mediated endocytosis followed by pore formation and translocation of the B and/or C components into the cytosol (I), although alternative mechanisms (e.g., II, III) cannot be ruled out.

Landsberg, MJ., Jones, SA., Rothnagel R., et al (2011)

24-01-18 | Max Planck Institute of Molecular Physiology

Imagine you're in charge of an invading army laying siege to your enemy's outer defences. How do you neutralise them?

One way would be to send a small group of soldiers, packed with high explosives and deadly toxins on a kamikaze mission into the defences, with instructions to detonate their explosives and so spread the toxins when inside to destroy the defences and kill the defenders. You could improve on that by removing any temptation the suicide bombers might have to not detonate their defences by automating the trigger to fire as soon as they encountered the defender.

That's exactly what a team at the Max Planck Institute for Molecular Physiology (MPI MOPH), Dortmund, Germany, have found bacteria use to gain access to their victim’s body and make their hosts sick and die. The team, led by Stefan Raunser, Director of MPI MOPH, have published their findings, open access, in Nature Microbiology. Their work is described in a MPI MOPH press release:

Malevolent Design - How The Divine Sadist Makes One in Three Infected Babies' Future Lives Difficult Even If They Recover From Bacterial Meningitis

Photo: Getty Images

Bacterial meningitis damages one in three children for life | Karolinska Institutet Nyheter

Left untreated, bacterial meningitis is usually fatal, but even if it is treated with antibiotics and the patient recovers, creationism's divine sadist who designed the bacteria, ensures one in three of them will be lefts with varying degrees of disability, including mental impairment, blindness, deafness or loss of motor control that will be with them for life.

This is the conclusion of a new study published two days ago in JAMA Network Open. It was conducted by a team under the leadership of Federico Iovino, associate professor in Medical Microbiology at the Department of Neuroscience, Karolinska Institutet.

The team compiled data on 3,500 people who contracted bacterial meningitis as children between 1987 and 2021 and compared them to just over 32,000 matched controls from the general population. The average follow-up time was 23 years.

As the news release from the Karolinska Institutet explains:

Malevolent Design - No Fun For Creationists As The Candida Family of Fungi Are Evolving To Keep Infecting Us

A Candida albicans cell forming a hyphal extension

Candida auris causes multidrug-resistant infections that can result in organ failure

Credit: Kateryna Kon/Science Photo Library

Candida evolution disclosed: new insights into fungal infections | IRB Barcelona

The Candida genus of fungi are related to yeasts (i.e., single-celled fungi) but are specialists at living in or on our bodies and are common infections in body cavities such as the mouth, anus, vagina and urethra and the genito-urinary and respiratory tract, and other moist areas like armpits, inner surfaces of joints like the elbow and knee, groins and fold beneath breasts and buttocks.

They can also become systemic infections causing organ failure and death, especially in people who are immune compromised for any reason. So, they are a threat to people who are in generally poor health, who have had transplants and need to take immunosuppressive drugs, or people receiving chemotherapy for cancer.

And, like some bacterial pathogens, they are good at evolving immunity to anti-fungal medication.

One species, Candida auris, has evolved multiple drug resistance and is now a serious threat to people in hospital for other conditions.

Now, a research group from the Institute for Research in Biomedicine (IRB Barcelona) and the Barcelona Supercomputing Center - Centro Nacional de Supercomputación (BSC-CNS), led by the ICREA researcher Dr. Toni Gabaldón, has identified hundreds of genes subject to recent, clinically-relevant selection in six species of the fungal pathogen Candida. In other words, the genes that have given Candida species their clinically-relevant drug resistance.

First a little AI background to the Candida genus:

Unintelligent Design - How Creationism's Heath-Robinson Designer's 'Design' Causes Cancer

Pit Head (c. 1930) William Heath Robinson

Deregulation of Alternative RNA Splicing Promotes Pancreatic Cancer Pr | Moffitt

William Heath-Robinson was an English eccentric illustrator of ridiculously over-complicated solutions for (mostly) imaginary problems. His 'labour-saving' devices often took more people to operate them than the labour they saved.

His designs usually incorporated the most unlikely of objects, such as pianos or stacks of books to stand on, bent sticks to hold things up, pulleys and levers, held together with pieces of string, which never failed to have a knot in them because they had been made from shorter lengths tied together. And the amazing thing was, when you looked at them, it looked though they really would work, and if you took any component away, the whole thing would fail.

What he probably didn't appreciate at the time, was how closely his 'intelligent' designs resembled the designs of creationism's putative designer, but they are almost perfect metaphors for the detail beneath the superficial appearance of design in living organisms, especially the processes and mechanisms that look irreducibly complex.

Take, for example, a consequence of the failure of a 'Heath-Robinson' mechanism for correcting a problem with how RNA is built using templates in DNA which are scattered over several sections of DNA instead of being in a single, contiguous lengths. The different fragments of RNA that this initially produces must then be spliced together (just like William Heath-Robinson's pieces of string).

And of course, being a 'Heath-Robinson' machine, even this little section of the process of protein production is not simple. Splicing is a complex process involving the protein, RBFOX2, and when this fails in pancreatic cells, the resulting faulty RNA molecules can lead to cancer and metastasis of those cancer cells is itself facilitated by reduced RBFOX2.

How the failure of this correction mechanism causes pancreatic cancer was discovered by an international team of researchers led by Assistant Professor, Karen Mann, Ph.D., of the Department of Molecular Oncology, Moffitt Cancer Center, Tampa, FL, 33612, USA, with colleagues from The Tisch Cancer Institute; St. Jude Children’s Research Hospital; the Agency for Science, Technology and Research in Singapore; and the University of Otago in New Zealand.

Of course, the real problem here isn't with the designer but the mindless design process that produces these over-complicated, utilitarian 'Heath-Robinson' solutions to problems. DNA is RNA's data store and, so long as it works better than what went before it, there is no pressure to sort out and 'defrag' the DNA, so the irreducibly complex 'Heath-Robinson' machine might fail and cause pancreatic cancer occasionally, but the proteins the pancreas produces are worth the occasional failures, and mindless evolution has no concern for the suffering caused.

Here is how the team described their findings in Nature:

Malevolent Designer News - The Brilliance of Creationism's Divine Sadist

Scanning electron micrograph of Salmonella typhimurium invading a human epithelial cell.

New insights into what helps Salmonella cause infections | Carl R. Woese Institute for Genomic Biology

Salmonella

The brilliance of creationism's favourite sadist was on display again recently, when researchers from the Department of Microbiology, University of Illinois at Urbana Champaign, Urbana, Illinois, USA, showed how the pathogen, Salmonella, is designed to not only survive being engulfed by the macrophages in our blood that are supposedly designed to protect us, but positively thrives and multiplies inside them. Although rarely fatal, Salmonella infection can be distressing and unpleasant with vomiting and diarrhoea, as I can attest from my childhood in rural Oxfordshire at a time when food and water hygiene left much to be desired.

So, it looks like creationism’s intelligent [sic] designer won that particular arms race with itself, in favour of the nasty pathogen designed to increase the suffering in the world. At least, that's the sort of nonsense creationists needs to believe to retain the childish belief that living things are made by a magic man in the sky.

The fact that salmonella can live happily inside a macrophage supposedly designed to kill pathogens has been known for some time, but what the University of Illinois researchers have discovered is just how it manages the trick. It's all down to the structure and function of the bacterium's surface membrane which detects and adjusts to the conditions in which the organism finds itself.
First, a little AI background on the pathogen:

Unintelligent Design - Neurodegenerative Diseases Such As MS & Alzheimer's Traced Back To Early North European Farmers - 24,000 Years Before 'Creation Week'

Bronze Age Genes.

Credit: SayoStudio

Life in Bronze Age Britain (artist's impression)

Ancient DNA reveals reason for high MS and Alzheimer's rates in Europe

Researchers have just completed a massive gene bank for ancient humans who lived in Eurasia up to 34,000 years ago (i.e., up to 24,000 years before creationist dogma says the universe and everything in it was magicked out of nothing by a god made of nothing who self-assembled out of nothing before there was time and space to self-assemble in.

The gene bank has enabled researchers to trace the historical and geographical spread of genes and diseases, producing four papers published in Nature. This article deals with just one of them; others will follow.

The results should disturb any creationists who has the courage to read about them because, not only did it all occur long before the mythical 'Creation Week' that is central to their superstition, but is shows that any designer either could not have been omniscient, or must have been malevolent, because it shows how the genes for Multiple Sclerosis (MS) arose in North Europe, probably as a side-effect of evolving genes to increase resistance to the diseases carried by domestic animals. An omniscient designer who deigned them should have been aware of what they would also cause, so either isn't omniscience and didn't know what its design would do, or created MS deliberately.

As the University of Cambridge News release explains:

Unintelligent Design - How Creationism's Incompetent Designer Tries To Fix It's Bad Design

New Study Reveals Crucial 'Housekeeping' Genetic Elements and Their Potent Role to Fight Cancer｜THE INSTITUTE OF MEDICAL SCIENCE, THE UNIVERSITY OF TOKYO

The thing about Creationism's putative intelligent [sic] designer is that it isn't just your common or garden variety of jobbing designer; it is allegedly omniscient, omnipotent and perfect, so anything it designs should be perfectly designed to do exactly what it does, nothing more and nothing less. Creationists need to ignore that aspect of its designs when it comes to the problem of all the parasites that live on and in the animals and plants it supposedly created or they need to perform some double-think mental gymnastics and blame something else which, even though their putative intelligent designer is the only entity capable of designing anything living, also designs things.

Creationists also need to ignore the fact that good design is minimally complex and pretend it’s a hallmark of good design. But imagine a manufacturing process that is so badly designed that it needs whole layers of sub-processes to correct the mistakes, and then those sub-processes need more sub-processes to correct their mistakes!

Presumably, a creationist would look at that system with its vast array of monitoring and error corrections as evidence of intelligent design, regardless of the waste and inefficiency built into the system. In reality, of course, any competent process designer would get it right first time, or would scrap a bad design and start over, learning the lessons of earlier failures, so designing the perfect system with minimal complexity and minimal waste should not be beyond the wit of a perfect, omnipotent omniscient designer, should it?

Alas, what we see in nature is nothing like perfectly designed processes; instead, we see muddle, waste and inefficiency with layer upon layer of sub-processes simply to cope with the errors in the processes.

An example of just this situation inside the cells of our allegedly intelligently design bodies was discovered recently by a team of researchers from the Laboratory of Functional Analysis in silico (Nakai-lab) at The Institute of Medical Science, The University of Tokyo, Japan, led by Professor Kenta Nakai, head of the laboratory, and Dr. Martin Loza, Assistant Professor, in collaboration with Dr. Alexis Vandenbon, Associate Professor, from the Institute of Life and Medical Sciences, Kyoto University, Japan. Their work was published, open access, in Nucleic Acids Research on December 12, 2023.

The team found as many as 11,000 gene regulators, all needed for basic 'housekeeping' and error corrections within the cell. These are known as housekeeping cis-regulatory elements (HK-CREs). These elements are vital in maintaining cellular stability beyond conventional gene regulation, influencing diverse cellular functions across healthy cell types. Moreover, a subset of these housekeeping elements, particularly those related to zinc finger genes, was found to have reduced activity in diverse cancers, suggesting their role as potential housekeeping tumor suppressors.

These HK-CREs were believed to be simple on/off switches that regulated the activity of housekeeping genes, but that was far too simple for whatever designed this complex process, of course. The Japanese team found that these switches aren't only important for the enhancement of specific genes but are crucial for the basic functions that keep our cells healthy. In other words, they are needed to clean up and correct the mistakes in the basic cell functions.

Given the significant association between cancer and mutations in epigenetic components, every small insight we gain could be key in the ongoing battle against this disease, which has tragically claimed innumerable lives. Through extensive bioinformatics analyses, we aimed to emphasize HK-CREs profound impact on fundamental cellular processes, including their potential as essential housekeeping tumor suppressors.

Assistant professor Dr. Martin Loza, lead author
The Institute of Medical Science
The University of Tokyo, Japan

To summarise at this point then, the housekeeping genes (HKRs) are needed to clean up the errors and mess of a badly designed process, but then they need more genes (HK-CREs) to regulate their activity!

But it gets worse!

Malevolent Design - How A Cat Poo Parasite Can Change Your Personality

Toxoplasma gondii is an obligate intracellular, parasitic protozoan that causes the disease toxoplasmosis. Diagram of Toxoplasma structure.

Image Credit: Designua / Shutterstock

Toxoplasma 'cat poo' parasite infects billions – so why is it so hard to study?

In my last blogpost, I described how the parasitic organism, cryptosporidium, is one of those 'irreducibly complex' organisms that creationists have been fooled by Michael J Behe into believing are proof of their putative creator god, because, so their ignorant intuition tells them, there can only be one intelligent designer capable of designing an irreducibly complex structure such as the bacterial flagellum or the apical complex structure that all members of the Apicomplex phylum characteristically possess.

Sadly for them, though, their reliance on this 'proof' of their god precludes them from arguing that these nasty little pathogens that appear to be designed to make us and other animals sick is the work of another intelligent creator, 'Sin', so the inescapable conclusion must be that their beloved creator god is designing these pathogens to make us sick and to increase the suffering in the world.

As though that wasn't bad enough, we now have another related parasite, also a member of the Apicomplex phylum, that on the face of it, seems to be an even more determined attempt to make us sick. It's a parasite that once you have it, you have it for life, and the evidence is that it manipulates your behaviour and changes your personality too. This then raises doubts about the idea of free will that is a central part of creationist superstition, and notions of 'Original Sin' (that thing that can supposedly create parasites too).

This organism is Toxoplasma gondii which is carried by about 25% of the world's people, so the chance of you or me or any of your friends and family having it is quite high.

Malevolent Design - More Nastiness From The Pestilential Designer, Or God, As Creationists Call It

Infections from a diarrhoea-causing parasite are on the rise in the UK – but experts aren't quite sure why

Cryptosporidium is a eukaryote protozoan parasite which creationists dogma says must have been designed by their favourite designer because that is the only entity capable of designing complex organisms, including 'irreducibly complex' structures.

Embarrassingly for creationists who are hoping to be able to blame 'Sin' for them, they are hung out to dry on the same hook that Michael J. Behe hung them on with the flagellum of the pathological E. coli bacterium, which they now happily wave as 'proof' of their designer good. Protozoans of the Apicomplexa phylum, of which the cryptosporidia are species, all have the apical complex organelle which is essential for them to break into a cell in order to infect it.

The characteristic apical complex organelle of the Apicomplexa phylum

Cryptosporidia appear to have two functions: to increase the suffering in the world by causing gastrointestinal disorders, usually resulting in severe diarrhoea; and to make more copies of themselves to infect more people and animals and spread the suffering more widely. They have no known beneficial functions in respect of humans or their other host species.

The species Cryptosporidium hominis is an obligate parasite on humans, so, according to creationists superstition, must have infected one or two of the Ark survivors, assuming there were no more than two individuals of the species present. Either that, or, according to creationist mythology, it has been created in the last four thousand years, which rules out being created by 'Sin' as a result of 'The Fall', which would mean it predates creationism's genocidal flood.

First, some AI background by way of introduction to the subject:

Unintelligent Design - How Creationism's Intelligent [Sic] Designer Stupidly Competes With Itself In An Arms Race.

These microscope images show how interferon in the nucleus raises levels of the protective protein IFI16 (stained green) from low background levels (left) to the higher levels needed to resist herpes infection (right).

Image: HMS MicRoN core imaging facility/
Nicolas Romero Rata

Oral Herpes simplex

How the Immune System Fights to Keep Herpes at Bay | Harvard Medical School

Throughout the Cold War, starting soon after World War II and continuing through most of the second half of the 20th Century, the world's great powers, led by America on one side and Russia on the other, competed in a wasteful arms race where one side tried to outdo the other by building more powerful bombs and better delivery systems while also building better defences capable of preventing successful attack by the other. Money and resources that went into this ultimately pointless arms race could have been used for better, more peaceful projects like better world health care, better education or ending poverty and famine, yet neither side could afford to do the sensible thing because neither side trusted the other to abandon the race and compete with peace instead.

Although we can understand the pressures and insecurities that caused these wasteful arms races, we can also see the ultimate futility of it all and how the costs escalate with every turn of the spiral.

But how much more stupid would it have been if both 'sides' had the same people running them - if both America and Russia had the same political and military leaders? In other words, if the arms race was being run by one side alone, for no better reason than that the leaders had amnesia and didn't know why they built a bigger bomb or a better defence system yesterday and woke up today faced with a threat they had designed yesterday and needed to spend today designing ways to cope with these new threats?

One might be tempted to call into question the sanity of these leaders and wonder about their fitness to lead. What on Earth had allowed them to behave so stupidly? And for what reason? It certainly would have had nothing to do with the health and welfare or safety of the populations of Russia or America, or indeed the rest of the world, so could not be excused as some sort of well-intentioned altruism. An OCD or sheer malevolence, maybe, but not benevolence.

And yet creationists worship what they believe is a supernatural entity who behaves exactly like the amnesiac maniac I've just described. The natural world it reputedly designed, according to creationists, is full of example of these pointless and wasteful arms races for no ultimate long-term benefit to either 'side'.

Malevolent Design - How A Chicken Virus Got More Deadly - Malice Or Evolution?

Ancient DNA reveals how a chicken virus evolved to become more deadly | University of Oxford

Marek's Disease Virus (MDV) is a serious infection in chickens that costs th4e poultry industry over $1 billion annually. Now an international group of virologists and archaeologists led by researchers from Oxford University, Ludwig-Maximilians-Universitat, Munich, Germany, have discovered how it has evolved over time to become more virulent and deadly, or, as creationists insist, has been intelligently redesigned.

The team reached this conclusion from an analysis of the virus in modern and ancient chickens going back over the past 1000 years. The ancient samples were obtained from DNA extracted from chicken bones recovered from 140 archaeological sites in Europe and the Near East. This analysis showed that MDV was widespread in European chickens for at least 1000 year before being first described in 1907.

Unintelligent Design - Why Some Women Experience Morning Sickness during Pregnancy.

As many as seven in ten pregnancies are affected by nausea and vomiting.
1-3% are severe enough to require hospital treatment

Why seven in ten women experience pregnancy sickness

'Morning sickness, which is common in the earlier stages of pregnancy, and which, in its more severe form, hyperemesis gravidarum, can be seriously debilitating and may even require admission to hospital and iv fluids to prevent life-threatening dehydration, is now known to be caused by a protein hormone, known as GDF15, produced by the foetal part of the placenta.

This discovery, published yesterday in Nature, by a team from Cambridge University, UK, led by Professor Sir Stephen O’Rahilly, and including researchers in Scotland, the USA and Sri Lanka, points to a potential way to prevent pregnancy sickness by exposing mothers to GDF15 ahead of pregnancy to build up their resilience.

It had previously been suggested that GDF15 might be acting on the mother's brain to make her feel nauseous. This has now been confirmed and found to be dependent on two factors:

1. How much of the hormone is being produced.
2. How sensitive to it the mother's brain is.

GDF15 is produced in low levels by all tissues outside of pregnancy and the mother's sensitivity to the hormone is related to how much of it she has been exposed to prior to becoming pregnant.
The team arrived at this conclusion after obtaining data from women recruited to a number of studies, including at the Rosie Maternity Hospital, part of Cambridge University Hospitals NHS Foundation Trust and Peterborough City Hospital, North West Anglia NHS Foundation Trust. They used a combination of approaches including human genetics, new ways of measuring hormones in pregnant women’s blood, and studies in cells and mice.

The team found that a rare genetic variant that puts women at a much greater risk of hyperemesis gravidarum was associated with lower levels of the hormone in the blood and tissues outside of pregnancy. Similarly, women with the inherited blood disorder beta thalassemia, which causes them to have naturally very high levels of GDF15 prior to pregnancy, experience little or no nausea or vomiting.

Most women who become pregnant will experience nausea and sickness at some point, and while this is not pleasant, for some women it can be much worse – they’ll become so sick they require treatment and even hospitalisation. We now know why.

The baby growing in the womb is producing a hormone at levels the mother is not used to. The more sensitive she is to this hormone, the sicker she will become.

Knowing this gives us a clue as to how we might prevent this from happening. It also makes us more confident that preventing GDF15 from accessing its highly specific receptor in the mother’s brain will ultimately form the basis for an effective and safe way of treating this disorder.

Professor Sir Stephen O’Rahilly, co-senior author.
Co-Director of the Institute of Metabolic Science
and Director of the Medical Research Council Metabolic Diseases Unit
University of Cambridge, Cambridge, UK

When I was pregnant, I became so ill that I could barely move without being sick. When I tried to find out why, I realised how little was known about my condition, despite pregnancy nausea being very common.

Hopefully, now that we understand the cause of hyperemesis gravidarum, we’re a step closer to developing effective treatments to stop other mothers going through what I and many other women have experienced.

Dr Marlena Fejzo, co-senior author
Center for Genetic Epidemiology
Department of Population and Public Health Sciences
Keck School of Medicine
University of Southern California, Los Angeles, CA, USA

The problem for creationists here is to explain why their putative designer god designed a protein which is normally very mild but rarely, can kill the mother and child and at the very least makes pregnancy a misery for a large number of women.

Their problem is compounded by the fact that, in this case, they can't blame it all on 'Sin' and let their little pet good off the hook, because the culprit, GDF15, has several important functions unrelated to pregnancy, so the side effects such as morning sickness and hyperemesis gravidarum appear to be an unforeseen consequence of it. No intelligent [sic] designer worthy of the name, especially a reputedly omniscient, omnipotent one, would design a protein hormone with unforeseen consequences, so we have to assume either it knew what it would do and didn't care, or it knew what it would do and designed it for that purpose. Briefly, GDF15 does the following:

What biological function does the hormonal protein GDF15, have? Growth Differentiation Factor 15 (GDF15) is a protein that plays a role in various biological processes, particularly in the regulation of energy balance and metabolic functions. Here are some key aspects of GDF15's biological functions:

1. Appetite Regulation: GDF15 is known to act as a satiety signal, meaning it can reduce appetite and food intake. It is produced in response to conditions such as inflammation, tissue damage, or cellular stress, and it signals to the brain to decrease food consumption.
2. Metabolic Regulation: GDF15 has been implicated in the regulation of metabolism. It can influence energy expenditure and may contribute to the control of body weight. Its levels are often elevated in conditions associated with weight loss, such as cancer or certain chronic diseases.
3. Anti-inflammatory Effects: GDF15 has anti-inflammatory properties and can modulate the immune response. It may play a role in limiting excessive inflammation during certain physiological or pathological conditions.
4. Cardioprotective Effects: GDF15 has been associated with cardioprotective effects. Elevated levels of GDF15 are often observed in response to cardiovascular stress, and it may have a role in protecting the heart and blood vessels.
5. Cancer-Related Functions: GDF15 is expressed in various tissues, and its levels are often increased in certain types of cancer. It may have both tumor-suppressive and tumor-promoting effects, depending on the specific context and type of cancer.

The exact mechanisms through which GDF15 exerts its effects are still an active area of research, and its functions can vary in different physiological and pathological conditions. It's important to note that the understanding of GDF15's functions is continually evolving as new research findings emerge.

So, creationists have a three-way choice here: Is this a result of:

1. Incompetence?
2. Malevolence?
3. Evolution?

Unintelligent Design News - How A Badly Designed Protein Causes Autoimmune Diseases

3D structure of Dectin-1 protein of Bubalus bubalis.

Yadav, B.; Tripathi, V.; Kumar, A.; et al (2012)

William Heath Robinson

Fungus-fighting protein key to overcoming autoimmune disease and cancer | Australian National University

The more you learn of creationism's putative intelligent [sic] designer, the more like William Heath Robinson it becomes.

The main difference is that, no matter how ramshakled they were, William Heath Robinsons inventions actually worked, even if they didn't produce the required result. The same can't be said for creationism's god's designs. They resemble piecemeal designs where each part is designed in isolation in response to a problem, often a problem somewhere else in the design, where near enough is good enough and there is no joined up thinking.

Rather like a William Heath Robinson machine, conbbled together from disparate parts, but where when a knotted piece of string breaks, instead of replacing it with a new piece of string or tying the broken ends together, like Heath Robinson would, a different, weaker sort of string is designed and tied across the broken ends, but then that keeps breaking too.

An example of this inept design was discovered recently and found to be the cause of autoimmune diseases such as iritable bowel syndrome (IBS), type 1 diabetes, eczema and other chronic disorders. The problem is with a protein called DECTIN-1 (also known as CLEC7A) which is producd by the immune system in response to fungal infections. Researchers at The Australian National University (ANU) have discovered that a mutated form of DECTIN-1 limits the production of T regulatory cells or so-called ‘guardian’ cells in the immune system.

Mutations arise, of course, because of another poor design - the process for replicating DNA, which is so prone to errors that another mechanism for repairing it is needed. However this is also prone to errors, the result of which means that many of our cells carry mutations, some of which cause cancers.

The research is publshed in Science Advances and ex[lained in an Australian Nationa University News release:

Unintelligent Design - Or Is It Malevolence? How Bacteria Are Designed to Exploit Our Mucus

[left caption]

[Right caption/credit]

Movement of mucus in the respiratory tract

Blausen.com staff (2014). "Medical gallery of Blausen Medical 2014"
Via Wikimedia (CC BY 3.0)

Bacteria's mucus maneuvers: Study reveals how snot facilitates infection | Penn State University

The mucous membrane lining our respiratory system has evolved (or, according to creationists, been intelligently [sic] designed) to keep our respiratory system clean as we breathe in air containing particles of dirt, dust, pollen and bacteria. It does this by secreting mucus that traps the particles, then ciliated cells on the surface sweep them towards our pharynx to be swallowed and disposed of in our digestive system where the proteins in the mucous are recycled.

Other body cavities are lined by a mucous membrane that serves to protect and keep the cavity moist and lubricated.

But, in one of those research papers that creationists have to avoid reading, a team of researchers from Penn State University, have shown how bacteria have evolved (or been intelligently [sic] designed, according to creationists) to exploit the mucous, the better to infect us and make us sick, and the thicker the mucus, the better it is for these would-be pathogens.

Infections by bacteria, known medically as opportunist infections, especially in the nasal sinuses and lungs, are a frequent complication of viral infections such as a common cold or influenza. These opportunist infections can be more dangerous than the virus infections that facilitate them.

The team showed that bacteria find it easier to swim, swarm and form colonies in thick mucus than in thin, watery mucus and that this swarming probably helps protect them from the antibacterial enzymes in the mucus.

Their research is explained in a Penn State news release:

Malevolent Design News - How 'Intelligently Designed' Pathogens Use The Tactics Of A Burglar To Make Us Sick

Model pathogen, Toxoplasma gondii

[Right caption/credit]

Pathogens use force to breach immune defenses, study finds: IU News

Creationists trying to defend their magic creator god argue that it didn't create pathogenic parasites and instead blame it on 'Sin'. Sadly for them, however, one of their leading cult gurus, Michael J. Behe, has pulled that rug from underneath them by writing a book in which he used the supposedly irreducibly complex flagellum of a common pathogen, Escherichia coli (E. coli) to argue that it must have been intelligently designed, (so God did it!). Behe's book, 'Darwin’s Black Box' is constantly being cited as 'proof' that the reputedly omniscience, omnipotent creator god of the Bible and Qur'an is real and creates things.

So, let's go with their 'proof of God' argument and assume therefore that pathogens are the intentional design of their putative designer god and were designed for the function they perform - making us sick, while producing more copies of themselves to make others sick too.

Now a team of researchers have shown the lengths this alleged designer god has gone to to continue making us sick and suffer. The team, led by Professor Yan Yu, of the College of Arts and Sciences’ Department of Chemistry, Indian University, Bloomington, IN, USA have shown that the intracellular pathogens like Toxoplasma, tuberculosis, malaria and chlamydia don't use subtlety to gain entry into the cell, probably because this would provoke an immune response as our immune system, allegedly designed by the same intelligent designer to protect us from the pathogens it designed to harm us, tried to fight back. Instead, they use brute force to break into the cell and once inside use the same force to break into a cell vacuole where they are protected by the internal cell membranes.

How the research team which included Professor Yan Yu's colleagues from Indiana University with Thomas K. Gaetjens and Steven M. Abel of the Department of Chemical and Biomolecular Engineering, University of Tennessee, Knoxville, TN, USA, made this discovery is explained in an Indian University new release:

Antivax COVIDiot News - Study Shows Vaccines Halted The Rise In Prem Births Caused By COVID-19

Covidiot Trumpanzees.
Risking the lives of unborn babies for political ends.

Study: Spike in premature births caused by COVID, halted by vaccines

About the last thing the politically-motivated, far right antivaxxers covidiots are interested in is protecting human life. With characteristic hypocrisy, many of the same frauds are also active campaigners against legal abortions and a woman's right to choose which, together with COVID-19 denialism and antivaxx conspiracism, have become major talking points in the Trumpanzee far right playlist.

The hypocrisy of these frauds was revealed yesterday in a study which shows there was a huge spike in the number of premature births during the early phase of the COVID-19 pandemic when women infected with the virus spontaneously aborted their baby. The same study also shows that in those areas where the vaccine uptake was high, the premature birth rate quickly fell back to pre-pandemic levels, but in areas where uptake was low, it took another year to return to pre-pandemic levels.

The study was carried out by Professor Jenna Nobles of Wisconsin–Madison University and Professor Florencia Torche, of Stanford University who have published their findings in Proceedings of the National Academy of Sciences (PNAS).

As the Wisconsin–Madison University press release explains:

Malevolent Designer News - Scientists Have Disovered the Sneaky Way Creationism's Putative Designer Created Childhood Leukaemia

Pediatric oncology: Scientists discover new Achilles heel of leukemia cells | Current news from the Goethe University Frankfurt

In leukemia, white blood cells divide uncontrollably.

Acute myeloid leukaemia, micrograph

Pediatric oncology: Scientists discover new Achilles heel of leukemia cells | Current news from the Goethe University Frankfurt

With the double-think that characterises creationsm, creationists will use, depending on what facts they are disputing, two mutually exclusive arguments:

1. A combination of the argument from ignorant incredulity and the false dichotomy fallacy. This argument depends on the assumption that there is only one supernatural entity capable of creating something as complex as DNA, with the conclusion "Therefore, God did it!", which of course is also a non-sequitur and an intellectually dishonest presupositional invocation of something unproven as evidence that it exists.
2. On another day, presented with something so patently evil as childhood cancer or nasty parasites that kill many and make life a misery for millions more (and not just humans, but just about every living thing) creationists invoke somethign called 'Sin' as being responsible for its design and/or creation.
   

In other words, they will argue both that their god is the only entity capable of creating anything, and that 'Sin' can create things too; and their supposedly omnipotent god is powerless to prevent it.

So, it will be interesting to see what arguments creationists will come up with to counter the argument that, if creationism has any substance, the same designer must have designed childhood leukaemia, in full knowledge of the suffering and grief it would cause not just to the child but to his/her parents and relatives.

But I suppose they could always cite William Lane Craig's repugnant defence of religiously-inpired infanticide - "killing children is not wrong because they go straight to heaven so it makes them happy".

But whatever excuse they make, creationists are hoist by their own petard in arguing the false dichotomy fallacy, so they are stuck with portrying the god they purport to worship as the designer of childhood leukaemia - a position they seem to prefer to having people accept that evolution by natural selection is responsible for the nastiness in nature as well as the wonderful.

So, given that a favourite subject for their argument from ignorant incredulity, is the structure of DNA, how will creationists react to the fact that a team of researchers from the Department of Pediatrics and the Institute for Experimental Pediatric Hematology and Oncology at Goethe University, Frankfurt, Germany has discovered a site in the DNA of cancer cells that is essential for leukemia cells to survive?

Creationism in Crisis - Which Side Should a True-Believing Creationist Be On? The 'Designer' Who Designs Resistance Or The Scientists?

Plasmodium falciparum parasites in a blood smear

Diagram of the complex eukaryote, Plasmodium falciparum

New approaches in the fight against drug resistance in malaria | FAU Erlangen-Nürnberg

Despite asking creationists multiple times how they reconcile believing that their putative intelligent [sic] designer designs complex organisms, such as the parasite, Plasmodium falciparum which cause malaria, with their belief that this putative designer is the supposedly omnibenevolent god if the Bible and Qur'an, I can never get a rational answer.

Most often they resort to the fallback claim that parasites and the suffering they cause were not created by their putative intelligent designer, but by another designer they call 'Sin', which of course is nonsensical and borders on blasphemy because it denies the supremacy of their supposed designer god, and allows for another designer over whom their supposedly omnipotent god is powerless.

But, to their embarrassment, if they manage to do the joined-up thinking, their guru, Michael J. Behe - who has the status of a 'brilliant scientist' in creationist circles - wrote a book, The Edge of Evolution in which he argued (wrongly) that the development of anti-malarial drug resistance in Plasmodium falciparum must have been intelligently designed, using the 'big scary numbers' tactic of arguing that the likelihood of each of the five steps needed arising by chance was so small, that the chances of all five of them occurring in the right sequence is so infinitesimally small that it couldn't have happened by chance alone, so needed divine intervention.

The fact that he used bad biology and even worse maths, in effect assuming that all the mutations had to happen together in as single cell as a single event, instead of in parallel across the species gene pool, as was shown by microbiologist Kenneth R Miller, is by the by, since creationists generally treat anything Michael J Behe says as proven science, they are stuck with his claim that their god is responsible for anti-malarial drug resistance in the malaria parasite - which infects about 20 million people, mostly children annually, and kills 700,000 of them.

Creationists also believe, contrary to the claim that humans have free will, that their god has a plan for each of us, so presumably planned to have those people die of malaria, and that to oppose their god's divine plan in any way is to oppose their god.

So, again a question I can never get a rational response to, is what should a true-believing creationist support - the god whom they believe creates parasites like malaria as part of its divine plan, or the biomedical scientists who work to thwart that plan?

This is of course, the sort of dilemmas that creationists need to avoid rather than have people accept that parasites like Plasmodium falciparum are the result of a mindless, amoral evolutionary process.

By contrast, and devoid of the sort of muddle, holding mutually exclusive views simultaneously, and dilemmas that creationism, with its evidence-free superstitions, gets itself into, the scientific view, supported by evidence, is:

Malevolent Designer News - How Creationism's Favourite Pestilential Sadist is Fighting Back Against Medical Science

Anopheles stephensi, spreading fast in Africa

Jim Gathany, Public domain
via Wikimedia Commons

Anopheles stephensi, already reached Ghana

First evidence of how the Asian malaria mosquito is spreading drug-resistant malaria in Africa - Lancaster University

You can never write Creationism's favourite sadist off in its battle to keep on killing children with its special tool, malaria. Just when you think medical science has it on the run and it looks possible that we could eradicate malaria like we did its other plaything, smallpox, it performs another twist of the arms race and redesigns the plasmodium parasite or a mosquito vector so they can evade our best efforts to protect children. And, pulling out all the stops, in this case, it's done both.

That's if you subscribe to the childish myth of a magic invisible designer creating all living things of course.

For normal people with a thinking ability above that of a slow 10-year-old, however, what we are seeing is an example of evolution by natural selection in response to an environment in which there are anti-malarial drugs and insecticides that kill mosquitoes.

Fact:
According to the WHO, there were an estimated 247 million cases of malaria worldwide in 2021 with over 600,000 deaths, mostly in Africa. Children under 5 accounted for about 80% of all malaria deaths in the region.

Before creationists start trying to cover their embarrassment, and absolve their god of blame by citing something called 'Sin', which apparently changed from a verb to a noun, materialised as an entity capable of operating outside the control of their supposedly omnipotent god and began creating living things too, may I remind them of their intelligent [sic] design guru, Michael J Behe's contribution to this debate.

Behe wrote one of their sacred books, The Edge of Evolution in which he used faulty logic and bad maths to try to prove that malarial resistance in plasmodium falciparum was intelligently designed, in order to appeal to his largely scientifically illiterate and gullible target readership. His 'argument' was destroyed by biologist Kenneth Miller however, when he pointed out that Behe had assumed in his maths that several mutations had to occur in sequence in a single cell as a single event - something that no evolutionary biologist would ever suggest - an argument that appears to have gone way over the heads of Behe's adoring readership.

Behe's faulty logic was in presenting evolution as something so highly unlikely that no evolutionary biologist would offer it as the mechanism by which evolution happens, then base his maths on that faulty logic and, voila! dutifully show that it is so highly unlikely that it probably didn't happen - so God did it!

Apparently, if you start off with a mechanism for evolution that no biologist in their right mind would ever suggest, you can easily show that it couldn't happen. Creationists regard this as 'creation science'!

But, true to form, Behe has now saddled creationists with the problem of blaming 'Sin' for something that he says was created by their putative intelligent [sic] designer, but then believing two mutually exclusive things simultaneously has never been a problem for creationists.

And that makes it all the more difficult for creationists to wave aside the evidence of malevolent intent, if we stick to the creationist superstition for a moment, in the news published recently in Nature Medicine that an insecticide-resistant species of mosquito Anopheles stephensi, capable of spreading drug and diagnostic-resistant strains of Plasmodium falciparum, has spread from Asia to Africa via the Horn of Africa and has already caused a surge in cases of malaria in Ethiopia, and this species is spreading at a fast rate never before recorded for a mosquito, having already reached Ghana in Northwest Africa. The finding, by an international team which includes Dr Luigi Sedda, from the Lancaster Ecology and Epidemiology Group at Lancaster University Medical School, Lancaster, UK, is outlined in a news release from Lancaster University:

Research by Lancaster University has led to the discovery of the role played by the Asian malaria mosquito (Anopheles stephensi) in the spread of drug and diagnosis-resistant malaria in Africa. Malaria is caused by a parasite which is spread by the bite of blood-sucking mosquitoes. According to the WHO, there were an estimated 247 million cases of malaria worldwide in 2021 with over 600,000 deaths, mostly in Africa. Children under 5 accounted for about 80% of all malaria deaths in the region.

Following its first detection in Djibouti in 2012, the Asian malaria mosquito Anopheles stephensi spread to the Horn of Africa (Ethiopia, Sudan, Somalia, and Eritrea) and beyond (Yemen, Nigeria, Kenya, and Ghana) at a speed unknown before for similar species.

People in households/dormitories with An. stephensi positivity had a 270% higher risk of malaria infection than those in households/dormitories where An. stephensi was not detected.

In addition, two other biological threats for the control of malaria were identified: drug resistance and diagnostic resistance of the parasite.

Dr Luigi Sedda, from the Lancaster Ecology and Epidemiology Group at Lancaster Medical School, is a joint first author on the paper which is published in Nature Medicine.

This is a very important finding. The mosquito that has spread in the Horn of Africa from Asia drove a major urban malaria outbreak in Ethiopia. An. stephensi is posing important public health concerns due to the increase in geographical presence, the capacity to persist throughout the year and to resist current insecticides, and to transmit drug and diagnostic resistant parasites.

The epidemiological characteristics of An. stephensi driven malaria can challenge the expectations for the new malaria vaccines to reduce the burden of malaria disease and deaths in Africa, the continent that was already highly hit by malaria and where successes in malaria reduction are currently stalled.

Dr Luigi Sedda, co-first author
Lancaster Ecology and Epidemiology Group,
Lancaster Medical School, Lancaster University, Lancaster, UK.

A water storage facility in a village in Ethiopia, a structure targeted by Anopheles stephensi

The capacity of Anopheles stephensi to use manmade water storage containers which are abundant in rapidly expanding African urban settings, coupled with its unique ecology, behavioural plasticity and resistance to major insecticides, makes it unamenable to conventional mosquito control tools. This latest evidence can change the prospects of malaria control and elimination in the face of any future intervention that ignores the presence of this invasive species.

The study was led by the Armauer Hansen Research Institute in Ethiopia with the collaboration of Lancaster University (UK), the Adama Science and Technology University (Ethiopia); University of California, San Francisco (USA); The London School of Hygiene and Tropical Medicine (UK); Radboudumc University Medical Center (The Netherlands); U.S. President’s Malaria Initiative (USA) and the Federal Ministry of Health (Ethiopia).

Well, you have to hand it to creationism's divine malevolence! Faced with the prospect of losing one of its best tools for killing innocent children and greatly increasing the suffering in the world, it has hit back hard and fast with a newly redesigned super mosquito to spread its newly-redesigned malaria parasites.

Of course, that's if you don't accept that evolution by natural selection is quite capable of producing this sort of response to anti-mosquito insecticides and anti-malaria drugs by the well-known evolutionary process biologists know as an evolutionary arms race - the antithesis of intelligent design.

Unintelligent Designer News - Scientists May Have Discovered The Design Flaw That Makes Our Immune System Fail When We Need It Most

Healthy (red) and exhausted (green) T cells in the spleen of chronically infected mouse.

Image: Ana Maria Mansilla / Institut für Systemimmunologie, Universität Würzburg

T-cells surrounding a cancer cell

JUAN GARTNER / Getty Images

Preventing the Exhaustion of T Cells - Universität Würzburg News

Our immune system is notoriously unreliable and often fails when it is needed most, with cancers and serious infections. As a piece of supposedly intelligent [sic] design, (according to creationist superstition) it is more an example of blithering incompetence, if not downright malevolence.

Remember, creationists believe the designer of it is supremely intelligent, omniscient with the power to foresee the future, omnipotent and perfect. Remember too that creationists claim, as the only supernatural entity capable of designing live things, that it also designed the pathogenic organisms that the immune system was designed to protect us from.

Apparently, in creationist circles, designing pathogens to make us sick, then designing an immune system to protect us from those pathogens, then redesigning the pathogens to bypass our immune system that should be protecting us from them, is considered evidence of supreme intelligence.

Similarly, designing a method of cell replication to replace out old cells when they wear out, but using a method that sometime makes mistakes and turns the cells into cancer cells is also a sign of infinite wisdom.

For reasons that can only be guessed at, and probably for political motives that depend on fools being misled about science and which have nothing to do with worshipping their particular god, creationist frauds would rather we thought of their putative designer god as an incompetent fool and pestilential malevolence, than accept that pathogens, cancers and our immune system are the result of a mindless, utilitarian natural process that operates without a plan and produces suboptimal results, providing the result is better than that which preceded it in terms of producing more offspring which go on to breed successfully.

For creationist frauds, religion merely provides them with an excuse for their avarice and demands for political power over others.