Shana - the daughter of a Neanderthal father and a Homo sapiens mother
Cover illustration for my book The Way of the Wolf
Cover illustration for my book The Way of the Wolf
AI-generated image (ChatGPT 5.2)
Evolutionary history is often represented as a neatly branching tree: an ancestral population divides, its descendants diverge, and each resulting lineage continues along its own independent path. Real evolution, however, is frequently much less tidy.
As I explained in my previous post on the Hawaiian honeycreepers, lineages that have begun to diverge can subsequently meet again and exchange genes through hybridisation. The result is reticulated evolution: an evolutionary history that is partly tree-like but also contains connecting branches where genes have passed between related populations.
The same principle applies to our own ancestry.
Modern humans, Neanderthals and Denisovans were not separately created, genetically sealed “kinds”. They were closely related human lineages produced by population separation and divergence, but that separation was never absolute. When populations encountered one another again, they sometimes interbred, allowing genes from one evolutionary branch to enter another—a process known as introgression.
Much of the resulting Neanderthal-derived DNA carried by people today may have little or no detectable effect. Some introgressed variants, however, continue to influence human biology. An international team led by Philipp Kanis of the Max Planck Institute for Evolutionary Anthropology and Hugo Zeberg of Karolinska Institutet has now investigated one particularly interesting example: the Neanderthal version of the growth-hormone receptor.
Their peer-reviewed paper in Current Biology examines two amino-acid substitutions in the receptor that were characteristic of Neanderthals. The growth-hormone receptor sits on the surface of cells and transmits the signal produced when growth hormone binds to it, helping to regulate the growth of bone, muscle and other tissues.
In laboratory-grown cells, the Neanderthal form of the receptor produced a stronger response to growth hormone than the common modern-human version. Under the experimental conditions used, cells carrying it grew by about 40 per cent more, with most of the increase attributable to one of the two Neanderthal-derived substitutions.































