AI-depiction of a celestial designer confused by its unintelligently designed arms race
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Uncovering the Rules of a Genetic Arms Race | HHMI
Creationists who claim that biologists are abandoning the Theory of Evolution in favour of intelligent design might benefit from looking at what biologists actually do, if only they could find the courage to read some actual science.
A good place to start would be the research of Howard Hughes Medical Institute investigator Harmit Malik and his colleagues, who investigate how genetic conflicts drive evolutionary change. Here, evolution is a working scientific framework: it supplies questions, generates testable predictions and helps researchers explain their experimental results.
No supernatural designer is required.
A study led by Tamanash Bhattacharya and published in
Science Advances describes this research programme. Working with Sindbis virus, the researchers investigated how an unusual genetic stop signal helps the virus evade its hosts’ immune defences.
This signal, known as the opal stop codon, helps maintain the integrity of tiny compartments in which the virus copies its RNA, shielding that RNA from immune detection. Its importance therefore depends on the opposition the virus encounters. In mosquito cells with functioning antiviral defences, selection strongly favoured viruses carrying the stop signal. Within five days — approximately 24 rounds of replication — viruses that had regained it almost completely replaced a variant lacking it. When the relevant host defence was disabled, the selective advantage changed, and variants without the stop signal could prevail.
That is evolution measured in the laboratory: heritable variation, differential reproductive success and a resulting change in the genetic composition of a population. The experiment reveals a mechanism through which host immunity shapes viral evolution. It also illustrates why “fitness” has no meaning independently of circumstances. A genetic variant advantageous in one environment can become disadvantageous when that environment changes.
Such conflicts make straightforward sense in evolutionary terms. Hosts benefit from restricting infection, while viruses benefit from overcoming those restrictions. Over evolutionary time, adaptations on either side can impose selection for counter-adaptations on the other. There is no foresight, agreed destination or concern for the welfare of the opposing side — simply competing lineages leaving different numbers of descendants.