How Evolution Works - The Founder Effect

The brown tree snake, Boiga irregularis

Photo: USGS

Photo: USGS

Study: Hidden genetic diversity may have helped inbred brown tree snakes take over Guam - University at Buffalo

Biological invasions present evolutionary biologists with an apparent paradox. A newly established population may begin with only a handful of individuals and therefore contain only a small sample of the genetic variation present in its parent population. The resulting population bottleneck should increase inbreeding, reduce its capacity to adapt and expose harmful recessive mutations to natural selection. In extreme cases, the population should succumb to what population geneticists call an “extinction vortex”, in which declining genetic diversity and declining population size reinforce one another.

And yet some introduced species do precisely the opposite. They survive, proliferate and overwhelm the ecosystems into which they have been introduced. Few examples are more spectacular—or more ecologically destructive—than the brown tree snake, Boiga irregularis, on the Pacific island of Guam.

Native to Australia, Papua New Guinea and other parts of the western Pacific, brown tree snakes probably reached Guam as accidental stowaways in military cargo sometime after the Second World War. The invading population is believed to have been founded by only a handful of snakes. Nevertheless, their descendants multiplied until, in some parts of the island, densities reached an extraordinary 30,000 snakes per square mile.

The consequences for Guam’s wildlife have been catastrophic. As nocturnal, generalist predators encountering abundant prey that had evolved without such a snake, they devastated the island’s native birds, causing several species to disappear from the wild on Guam. They have also disrupted food webs, preyed upon reptiles and small mammals and caused hundreds of power cuts by climbing electricity infrastructure.

But how did a population founded by so few individuals avoid collapsing under the burden of inbreeding?

A new paper in Science Advances by Christopher A. Osborne of the University at Buffalo and colleagues from Buffalo and the US Geological Survey suggests that the answer lies partly in a form of genetic variation that earlier sequencing methods tended to miss.

The snakes did not, in fact, avoid the bottleneck. Their genomes retain compelling evidence of it. The researchers found that roughly half of each snake’s genome consisted of long “runs of homozygosity”—regions in which the copies inherited from the mother and father were almost identical. This is a genomic signature of intense inbreeding, comparable with that seen in some endangered species of conservation concern.

However, genetic diversity is not confined to changes in individual DNA letters. Using long-read sequencing, which can detect much larger differences, the researchers found nearly 19,000 structural variants. These included sections of DNA that had been duplicated, deleted, inserted or rearranged. Together, these structural variants affected almost eight times as much of the genome as the single-nucleotide variants upon which conventional estimates of genetic diversity have largely relied.

More importantly, the surviving variation was not distributed randomly. Structural variants were especially abundant around gene promoters and in genes associated with adaptive immunity and olfaction. Variation in immune genes could help the snakes respond to pathogens, while variation affecting their highly developed sense of smell could influence their ability to recognise prey, exploit different foods and distinguish closely related snakes from potential prey. In other words, a population can be genetically impoverished overall while retaining disproportionately important variation in precisely those parts of its genome that influence survival and adaptability.

Creationism Refuted - Another Gap Closed with a 23-Million-Year-Old Fossil - Just as The Theory Of Evolution Predicted

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Reconstruction of Miyumba chrisdickmani in its natural setting.

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Australia’s most diverse marsupial predators have been hiding their origins for millions of years

To a palaeontologist, a gap in the fossil record is an unanswered question and an invitation to keep looking. To a creationist, it is more often treated as a convenient space in which to insert a supernatural explanation. The difficulty for creationism is that scientists have an inconvenient habit of finding the missing evidence, whereupon the gap becomes smaller, the evolutionary history becomes clearer, and creationists must quietly move their supernatural explanation somewhere else.

A particularly neat example is provided by a paper just published in Australian Zoologist by Timothy J. Churchill, Michael Archer, Suzanne J. Hand and Roy M. Farman. As Churchill explains in an article in The Conversation, a handful of tiny fossil jaws from north-western Queensland has supplied a previously missing opening chapter in the evolutionary history of Australia’s most diverse family of marsupial predators.

The family Dasyuridae contains almost 80 living species, including Tasmanian devils, quolls, dunnarts, planigales and antechinuses. They range from insect-eaters weighing only a few grams to the much larger Tasmanian devil, and occupy environments extending from the tropical rainforests of New Guinea to Australian deserts, grasslands and alpine woodland. Yet, despite this modern diversity, their early fossil history had remained frustratingly obscure.

Molecular studies indicated that dasyurids had diverged from their closest relatives millions of years before the earliest unambiguous fossils then known. Almost all accepted dasyurid fossils were younger than about five million years, leaving what palaeontologists call a “ghost lineage”: a branch whose existence was indicated by evolutionary relationships, but whose earlier fossil representatives had not yet been found. The animal once thought to fill that gap, Barinya wangala, was subsequently shown to belong to an entirely different family of peculiar, probably snail-eating marsupials called malleodectids.

Creationists sometimes present such gaps as evidence against evolution, apparently assuming that unless every organism that ever lived has obligingly become fossilised, been exposed at the surface and been discovered, the evolutionary history can be dismissed. But incompleteness is not inconsistency. Fossilisation is rare, suitable rocks are unevenly distributed, and tiny, fragile animals are especially unlikely to leave recognisable remains. Evolution nevertheless predicted that earlier dasyurids had existed. The question was whether any of them would eventually be found.

The new species, named Miyumba chrisdickmani, is known from six partial lower jaws recovered from Early Miocene deposits in the Riversleigh World Heritage Area on Waanyi Country. It lived about 23 million years ago and probably weighed only about 30 grams, making it comparable in size to a modern antechinus or large dunnart. It is now the oldest confirmed member of Dasyuridae, extending the family’s recognised fossil history by more than five million years.

Its significance, however, lies in much more than its age. The teeth of Miyumba possess a particular arrangement in which the third lower premolar is smaller than the first and second. This appears to be a shared derived characteristic, or synapomorphy, identifying dasyurids as a natural evolutionary group. At the same time, Miyumba retains several ancestral dental features expected in an animal close to the base of that group’s family tree.

That combination is precisely what evolutionary theory predicts: an early member of a lineage should possess the defining innovations inherited by its descendants while retaining features inherited from more distant ancestors. It should not look exactly like a modern Tasmanian devil, quoll or dunnart because those specialised forms had not yet evolved. Nor should it be unrelated to them. It should display a mosaic of ancestral and newly evolved characteristics — and that is exactly what Miyumba does.

How Evolution Works - Shell Shock For Creationists

Steinkern (internal mould) of Maclurites neritoides containing cryptic fauna cornulitids, bryozoans, and graptolites (arrows).

Credit: Vinn, O., Wilson, M.A., Tinn, O. et al. (2026)

Empty seashells became new habitats 470 million years ago | University of Tartu

A paper just published in Scientific Reports by an international team led by Olev Vinn of the University of Tartu, Estonia, provides a lovely illustration of the opportunistic nature of evolution.

Some 470 million years ago — almost 470 million years before creationists’ mythical ‘Creation Week’ — a seemingly modest ecological innovation occurred in the oceans: animals began using the sheltered interiors of empty mollusc shells as habitats. This happened during the Middle Ordovician, following the Cambrian radiation, and helped to establish a new ecological niche that remains important in marine ecosystems today.

Creationists like to misrepresent the Cambrian radiation as the sudden appearance of complex, multicellular animals without ancestors. In reality, it was neither instantaneous nor without an evolutionary prehistory. It unfolded over tens of millions of years and grew out of changes already under way among the preceding Ediacaran biota, including increasing mobility, burrowing and ecological interaction.

As animals became more mobile, predation intensified and defensive structures became increasingly advantageous. Mineralised skeletons and shells evolved independently in several lineages, probably under several interacting pressures, including protection, structural support and changing ocean chemistry. Molluscs were among the groups that acquired shells, and their subsequent diversification produced such familiar forms as gastropods, bivalves and shelled cephalopods.

One consequence was the growing accumulation of empty shells on the seabed. Each dead mollusc left behind a hard surface and a sheltered cavity that other organisms could potentially exploit. Yet the researchers found that, throughout the Cambrian, the interiors of mollusc shells and other skeletal remains remained free of encrusting animals, even though organisms capable of living on surfaces inside other cavities already existed.

That changed during the Middle Ordovician, when attached animals began colonising the relatively large, spacious shells of nautiloid cephalopods. They later spread into the empty shells of gastropods and bivalves. No foresight or planning was required: once organisms capable of settling inside these shells gained access to a protected surface supplied with food-bearing water, any heritable tendency that improved their ability to exploit it could be favoured by natural selection.

Creationism Refuted - How The Building Blocks Of Life Can be Made Without Magic

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Cosmic dust analogue seen through a microscope created by experiment by Linda Losurdo.

This student made cosmic dust in her lab. What she found could help us understand how life started on Earth - The University of Sydney

Creationist objections to abiogenesis often smuggle in the long-discredited idea of vitalism: the belief that living matter contains some special ingredient or “vital force” absent from non-living matter. This appears to lie behind the familiar creationist refrain that “life cannot come from non-life”, as though “life” were a substance that must be added to matter by a supernatural agent.

The word “life”, however, is rarely defined in this argument. Scientists can devise operational definitions for particular purposes, but life is not a single substance possessed by some molecules and absent from others. It is a collection of properties displayed by sufficiently organised chemical systems. By leaving the term undefined, creationists turn their assertion into a slogan that can neither be tested nor falsified.

The distinction between organic and inorganic chemistry is useful, but partly conventional and historical. Organic chemistry deals broadly with carbon compounds, although some carbon-containing substances—including carbon dioxide, carbon monoxide and carbonates—are traditionally classified as inorganic. There is no fundamental physical boundary between the two categories: both obey precisely the same laws of physics, chemistry and quantum mechanics.

Carbon’s extraordinary chemical versatility follows from its atomic structure. A carbon atom has six protons and six electrons, four of which are valence electrons in its outer shell. Its small size and ability to form strong covalent bonds with itself and with elements such as hydrogen, oxygen and nitrogen allow it to form stable chains, rings, branches and extensive molecular networks. Depending on how it is bonded, carbon can adopt tetrahedral, trigonal-planar or linear arrangements and can form single, double or triple bonds. All this follows from quantum chemistry; no vital spark, magical ingredient or special rule is required.

None of that proves that the origin of life was inevitable, and science does not yet possess a complete account of every stage of abiogenesis. What it does show is that there is no known chemical or physical barrier preventing non-living chemistry from becoming progressively more complex. Under suitable conditions, chemical systems can acquire such properties as compartmentalisation, catalysis and molecular replication. Once populations of replicating systems existed with heritable variation, natural selection could favour those that survived longer, reproduced more reliably and used available resources more efficiently.

One important question is where the organic raw materials involved in this prebiotic chemistry came from. Some could have formed on the early Earth, but organic compounds are also widespread throughout the Solar System and interstellar space. They have been detected in comets and asteroids and regularly occur in meteorites. Earth may therefore have received substantial quantities of organic material from several extraterrestrial sources. This raises another scientific question: what natural chemical and physical processes produced and modified that material in space?

Linda Losurdo, a PhD candidate in materials and plasma physics in the School of Physics at the University of Sydney, Australia, has investigated part of that question with her supervisor, Professor David McKenzie. They recreated some of the energetic, near-vacuum conditions associated with stars and other astrophysical environments inside glass tubes. After evacuating the tubes, they introduced nitrogen, carbon dioxide and acetylene and subjected the mixture to an electrical potential of about 10,000 volts for approximately an hour, producing a plasma known as a glow discharge.

Refuting Creationism - Death More Than 66 Million Years Before Mythical 'Sin'

A Tyrannosaur stalking an edmontosaurus

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"The Bite"

Paleoartist Jenn Hall.

Rare fossil at Montana State’s Museum of the Rockies records Tyrannosaurus attack

A paper published on 17 February 2026 in PeerJ by Taia C.A. Wyenberg-Henzler of la of Montana State University, USA, reports on a remarkable fossil from the Hell Creek Formation of eastern Montana: a nearly complete, articulated skull of an adult Edmontosaurus annectens with the broken tip of a tyrannosaur tooth still embedded in its left nasal bone.

The fossil dates from the closing stages of the Late Cretaceous, roughly 66 million years ago, shortly before Edmontosaurus, Tyrannosaurus and all other non-avian dinosaurs disappeared during the Cretaceous–Palaeogene mass extinction. The bone surrounding the embedded tooth shows no evidence of healing or remodelling, indicating that the bite occurred at, very near or shortly after the death of the Edmontosaurus.

In other words, this is physical evidence of a violent interaction between predator and prey tens of millions of years before humans existed—precisely the sort of evidence that creationists are conditioned to reject because it cannot be accommodated within their mythology. According to young-Earth creationism, there was supposedly no death, predation or suffering before human ‘sin’ allowed evil to enter the world and ruin their omnipotent creator’s previously perfect creation—apparently without that omnipotent creator either foreseeing or preventing it. And all this supposedly happened only 6,000–10,000 years ago, shortly after ‘Creation Week’.

The doctrine that no animal died before ‘the Fall’ is not stated explicitly anywhere in the Bible. It is a theological inference imposed upon the text because young-Earth creationism requires it. It belongs to the category of reasoning that says: ‘This must be true for the rest of my beliefs to be true; my beliefs cannot be wrong; therefore, this must also be true.’

Having granted themselves this assumption of infallibility, creationists must then protect it from every fact that contradicts it. The belief cannot be mistaken, so the evidence must somehow be misunderstood, fraudulent, planted by Satan, created with the appearance of age or otherwise unworthy of consideration. Anything, in fact, is preferable to the intellectually honest admission that the belief itself has been falsified.

In almost every other field of human endeavour, such a supremely arrogant claim to personal infallibility would be laughed at and its proponent told to grow up. Yet, when packaged as religious faith, it is not merely tolerated but frequently treated with respect. Its advocates demand—and often receive—special privileges and social status: ‘You must listen to me, allow me to make laws governing your life and let me shape society according to my beliefs because I have an invisible friend and wear special robes.’

And so creationism staggers on, obliged to deny a veritable deluge of scientific evidence rather than concede that its mythology bears no resemblance to the history of life on Earth.

Refuting Creationism - How Physics Constrained The Evolution Of Flight in Flies

High-resolution stacked image of the blowfly wing and thorax. The translucent wing attaches via an intricate hinge system to the muscular thorax that powers rapid wingbeats.

Carlos Faulquier

Why most flies fly alike | WUR

Carlos Faulquier

As a child growing up in the relative silence of a North Oxfordshire hamlet, I could sometimes hear bats overhead. On a still summer night, lying in the quiet of my bedroom, I could also make out the distinctive, high-pitched whine of a mosquito as it approached an exposed arm, guided at close range by body heat as well as by carbon dioxide and human odours. Both sounds now lie beyond what my ageing ears can detect. The relevance of that mosquito’s whine will become apparent shortly.

A paper published on 9 July 2026 in PLOS Biology by scientists from Wageningen University in the Netherlands and Aix-Marseille Université in France explains how aerodynamic constraints have channelled the evolution of flight across the Diptera — the order of insects that includes houseflies, fruit flies, mosquitoes, midges and crane flies.

The researchers examined the body and wing morphology of 133 species and recorded the hovering flight of 46 of them using high-speed stereoscopic cameras. They then used computational fluid dynamics to reconstruct the aerodynamic forces and energy costs associated with their wing movements.

They found that wing shape varied considerably and was strongly influenced by evolutionary ancestry, but that wingbeat movements were broadly conserved across most of the order. Despite the enormous diversity of dipterans in size, appearance, habitat and ecology, most have evolved strikingly similar flight mechanics because the physical requirements of remaining airborne restrict the range of workable solutions.

Evolution, of course, depends upon heritable variation, but not every imaginable variation is viable or advantageous. A change that demands more energy without providing some compensating benefit is unlikely to spread through a population. Natural selection therefore tends to channel evolution towards a comparatively narrow range of effective solutions. In this case, the need to generate sufficient lift while limiting aerodynamic power consumption has produced a broadly shared flight pattern across most dipterans.

It must be galling for those few creationists who can read and understand scientific papers, yet are still eagerly awaiting the long-promised day when biologists abandon “Darwinism” and embrace creationism, to encounter paper after paper such as this one. Once again, evolutionary theory provides the accepted framework within which the observations make sense, without so much as a hint that the researchers are preparing to replace it with supernatural magic.

An enterprising creationist might nevertheless seize upon the apparent exceptions. Mosquitoes and their close relatives, the midges, do not follow the usual energy-saving pattern. Mosquitoes can beat their wings as many as 1,000 times each second, using almost three times as much aerodynamic power as similarly sized fruit flies. Crane flies also depart from the general pattern, although in the opposite direction, having evolved unusually economical flight.

Surely, the creationist might argue, if aerodynamic constraints channelled the evolution of the other flies, mosquitoes should have been constrained in precisely the same way. If an exception exists, perhaps there is something wrong with the theory.

But this objection rests on the mistaken assumption that natural selection must optimise every characteristic for a single purpose. Evolution does not produce organisms in which each structure is independently perfected. It produces compromises between competing demands, with reproductive success ultimately determining which combination of costs and benefits persists.

The researchers found that mosquitoes and midges produce disproportionately powerful sounds for insects of their size. Their rapid, low-amplitude wingbeats generate increased aerodynamic drag and require enlarged flight muscles, making flight more energetically expensive. That apparent inefficiency, however, may provide a substantial reproductive advantage because acoustic communication plays an important part in their courtship.

Creationism Refuted - Earth Is 'Fine-Tuned' For Disasters And Mass Extinctions

Researchers confirm cause of Earth’s biggest mass extinction | Stanford Doerr School of Sustainability

Studying the metabolism of living brachiopods like these collected from San Juan Island, Washington, allowed Stanford researchers to understand how the physiology of the modern fauna and Paleozoic fauna may have differed and how these groups would have been differentially impacted by oxygen and temperature changes during the Permian–Triassic mass extinction.

Image credit: Erik Sperling.

Many of Earth's climatic, geological and biological processes behave as complex, nonlinear systems, resembling systems in chaos. In this context, “chaotic” does not mean random. It means that small differences in starting conditions can sometimes be amplified until they produce very different outcomes — the phenomenon popularly known as the “butterfly effect”. The butterfly is not literally responsible for a distant storm; it merely illustrates how a tiny disturbance can cascade through a sufficiently complex system.

This is not the picture of a planet engineered to remain permanently benign or perfectly “fine-tuned” for life — still less for human life in the United States. Earth is habitable, but its habitability is contingent and sometimes precarious. The same interacting atmospheric, oceanic, geological and biological processes that sustain life can, when pushed beyond critical thresholds, drive abrupt environmental change, ecological collapse and mass extinction.

At several points in Earth's history, reinforcing feedbacks have transformed relatively small initial disturbances into rapid and profound environmental changes. Organisms adapted to the previous conditions were then confronted with combinations of heat, cold, acidification, oxygen loss or other stresses occurring too quickly for most populations to adapt. The result was widespread extinction.

What has been less well understood is why some groups were devastated while others living in the same changing environment survived. This is an important question for us because every organism alive today is descended from lineages that somehow survived every previous mass extinction.

Research by a Stanford University-led team, recently published in the Proceedings of the National Academy of Sciences of the United States of America (PNAS), now offers an experimentally supported explanation for one of the most striking patterns associated with the end-Permian mass extinction — the “Great Dying” of about 252 million years ago.

Creationism Refuted - Why The Human Body Refutes Intelligent Design And Supports Mindless Evolution.

The human body isn’t a masterpiece of design – it’s a patchwork of evolutionary compromise

Back in December 2024, I published The Body of Evidence: How the Human Body Refutes Intelligent Design as part of my Unintelligent Design series. In it, I argued that:

Looked at objectively, beneath the superficial appearance of design, the human body, with its inefficiencies, vulnerabilities and vestigial features, is best explained through the lens of evolution.

Far from reflecting intelligent design, our anatomy and physiology reveal a history of incremental changes shaped by natural selection and constrained by pre-existing structures. These imperfections underscore the reality of evolution as a tinkering process, producing functional but far-from-perfect outcomes.

In this light, the human body stands as a powerful testament to our evolutionary heritage and tells a story far more impressive than the childish notion of it all being made by magic by a super-intelligent yet invisible and undetectable designer.

It is therefore gratifying to see those conclusions independently reinforced by Lucy E. Hyde, a Lecturer in Anatomy at the University of Bristol. In a recent article in The Conversation, she makes essentially the same case, drawing upon many of the same examples that I used.

This is not because anatomists and evolutionary biologists have agreed upon a preferred story and then set out to make the evidence fit it. It is because people who understand evolution and possess more than a superficial knowledge of human anatomy and physiology can examine the same evidence and independently reach the same broad conclusion: the human body is not the product of foresightful engineering but a historical patchwork of inherited structures, evolutionary compromises and modifications to what already existed.

Evolution explains not only why the human body works as well as it does, but also why it so often fails, why some of its structures follow absurdly circuitous routes, why others are poorly suited to their present functions and why still others persist despite having little or no remaining usefulness. “Intelligent design”, by contrast, explains none of this without retreating into the scientifically worthless claim that an unknowable designer must have wanted things that way.

Lucy Hyde’s article is reproduced below under a Creative Commons licence, with its formatting adapted for consistency with this blog:

Creationism Refuted - How Humans Acquired Their Pathogens From Their Animals - No Magic 'Sin' Involved

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We’ve long suspected that the transition to farming and animal husbandry opened the door to a new era of disease – now DNA shows us that it happened at least 6,500 years ago,” says Professor Eske Willerslev, author of the new study.

Illustration: William Brøns Petersen

Large-scale DNA study maps 37,000 years of disease history – University of Copenhagen

Young Earth creationist mythology has it that sin, shortly after the magical creation of two adult humans, caused death and disease to enter the world. Until then, so we are expected to believe, there had been no disease and nothing ever died — not even, apparently, the plants Adam, Eve and the other animals ate.

Reality, of course, is materially different from the mythology produced by scientifically ignorant ancient pastoralists and later scribes who knew nothing of bacteria, viruses, parasites, epidemiology or evolution, and who interpreted misfortune in magical terms. Disease was not a supernatural punishment introduced at a single moment by a talking snake, a disobedient couple and an irritable god. It was, and remains, a biological process involving organisms evolving, spreading, adapting and, sometimes, crossing from one host species into another.

And the evidence now shows that at least 6,500 years ago, diseases were passing from animals into the humans who lived alongside them. The domestication of animals, the growth of settled farming communities and the rise of pastoralism brought humans, livestock, waste, parasites and pathogens into much closer proximity than before. This has long been thought to explain why humans suffer from so many infectious diseases. It is also a point Jared Diamond made in Guns, Germs and Steel: The Fate of Human Societies, where he argued that Eurasia’s abundance of domesticable animals, and Europeans’ long exposure to the diseases associated with them, helped Europeans to dominate other populations, often with their pathogens acting as an advance guard against peoples with no previous exposure or immunity.

That view of the zoonotic origin of many human diseases has now been strongly supported by the work of researchers led by Professor Eske Willerslev, of the University of Copenhagen and the University of Cambridge, in a study published open access in Nature in July 2025. The team analysed DNA from more than 1,300 prehistoric individuals, some up to 37,000 years old. Their bones and teeth provided an extraordinary archive of ancient microbial DNA, revealing traces of bacteria, viruses and parasites that infected humans across deep Eurasian history.

The results suggest that close cohabitation with domesticated animals, together with large-scale migrations of pastoralists from the Pontic Steppe, played a major role in the spread of zoonotic diseases. The researchers found that identifiable zoonotic pathogens first appear in their data from around 6,500 years ago, became more widespread after about 6,000 years ago, and peaked roughly 5,000 years ago — precisely the sort of pattern expected if lifestyle, animal husbandry, mobility and population contact were driving disease transmission.

This is especially awkward for creationists because the evidence does not point to a sudden, supernatural transformation of the world’s biology. It does not show disease appearing overnight as the result of a mythical “Fall”. Instead, it shows a long, historical and evolutionary process, unfolding through early Eurasian human history as changing human behaviour created new ecological opportunities for pathogens.

Refuting Creationism - Population Collapse And Migration in Neolithic Europe - And No Evidence Of A Genocidal Flood

The researchers have conducted DNA analyses of the skeletons from a burial site like this one in France and found traces of several different diseases.

Photo: Getty Images / Michal Boubin

Stone age population collapse revealed by DNA study in France – University of Copenhagen

A paper published in Nature Ecology & Evolution by a large international team led by researchers at the University of Copenhagen, reports evidence that simply should not exist if the Bible creation myth, and its later global genocidal flood myth, had any basis in reality. The evidence shows a significant population collapse among Neolithic farming communities in what is now northern France about 5,000 years ago, followed by migration into the depopulated area by people with strong genetic links to southern France and the Iberian Peninsula.

The study is based on ancient DNA from 132 individuals buried in the allée sépulcrale at Bury, a large megalithic tomb about 50 kilometres north of Paris. The site was used during two distinct burial phases, separated by a hiatus associated with the wider Neolithic decline around 3000 BC. The researchers found that the people buried before and after this decline were not simply later descendants of the same local population, but belonged to largely discontinuous genetic groups. In other words, this was not merely a change in burial custom; it was a major population turnover.

The problems this presents for creationism are multiple. First, there is the evidence of established farming populations in northern Europe at a time when, according to Young Earth Creationist chronology, the world had only recently been magicked into existence. Secondly, there is the embarrassing survival of archaeological and genetic evidence which, under the same mythology, should either have been destroyed in a global flood a few centuries later, or buried beneath a distinctive, worldwide layer of fossil-bearing flood silt — a layer which is conspicuous by its absence. Thirdly, there is the evidence that the human population of Europe had already diversified into regionally distinct genetic populations by about 3000 BC, with enough structure for ancient DNA to distinguish northern French and German-like Neolithic farmers from later migrants with strong southern French and Iberian affinities.

None of this, of course, will cause creationists to reconsider the mythology. We can confidently predict that it will instead be treated as another test of faith: one more opportunity to demonstrate the strength of their determination never to let evidence change their minds. In creationist apologetics, refusal to learn is often mistaken for intellectual victory. The more compelling the evidence, the greater the achievement in ignoring it.

The reason for the population decline is not yet clear. The human remains contained genetic traces of pathogens, including the plague bacterium, Yersinia pestis, and the louse-borne relapsing fever bacterium, Borrelia recurrentis, but the evidence does not support plague as the sole cause of the collapse. The more likely explanation is a combination of disease, environmental stress, demographic disruption and social breakdown. Earlier burials contained multiple generations from the same extended families, suggesting stable, kin-based communities. Later burials were more selective and were dominated by a single male lineage, indicating a marked change in social organisation after the population turnover.

This adds to the growing picture of the so-called Neolithic decline as a widespread phenomenon affecting much of northern and western Europe, not just Scandinavia and northern Germany. It also offers a plausible explanation for the abrupt disappearance of megalithic tomb-building and other monumental traditions across parts of Europe at about the same time. The people who built those monuments did not merely change their minds about architecture; in places such as the Paris Basin, the population itself appears to have collapsed and been replaced.

Refuting Creationism - Humans And Wolves Share A Long Evolutionary History

View from the Stora Förvar cave on Stora Karlsö. The cave was explored between 1888 and 1893. The limestone-rich bedrock has contributed to the skeletal material found there being very well preserved.

Photo: Jan Storå

Ancient wolves on remote Baltic Sea island reveal link to prehistoric humans - Stockholms universitet

A point I have made several times in these blog posts, and one that creationists typically prefer not to address, is that the Bible presents living things as part of a world made for human use and dominion. Yet the history of animal and plant domestication tells a very different story. The domesticated forms often bear little resemblance to their wild ancestors, not because they were created perfectly fitted for human needs, but because humans altered them by selective breeding over many generations.

For an honest creationist, the question should be obvious: why did an allegedly omniscient creator god fail to anticipate human needs and create animals and plants already ideally suited to them? Why did humans need to do the improving? But, as so often, creationists appear to prefer belief in an incompetent designer to the simpler conclusion that their creation myth is wrong.

No domestic animal illustrates this better than the dog. Domestic dogs are descended from wolves, yet the vast range of dog forms, behaviours and abilities shows what prolonged selection, human preference and cultural need can do. Herding dogs, guard dogs, hunting dogs, sled dogs, lapdogs and companion animals are not the result of a single act of perfect creation; they are the result of human-managed evolution.

Now, new research by scientists from the Francis Crick Institute, Stockholm University, the University of Aberdeen and the University of East Anglia, published online in November 2025 in Proceedings of the National Academy of Sciences of the USA (PNAS), shows that human relationships with wolves were more varied and complex than a simple tale of fear, hunting or eventual dog domestication. The researchers report wolf remains from the isolated Baltic island of Stora Karlsö, in a context strongly suggesting that prehistoric people were managing, feeding or otherwise controlling wolves thousands of years ago.

This research resonates with me because two of my books, The Girl and the Wolf and The Way of the Wolf: A Stone Age Epic, are fictional accounts of how wolf domestication might have begun. In those stories, the process is initiated by a single act of compassion: a woman raises an abandoned wolf cub alongside her own child. That act becomes a legend, and the legend later inspires another tribe to form a relationship with wolves, helping them to survive hardship and setting humanity on a path that would eventually produce the many varieties of domestic dog, each shaped for different human purposes.

The stories are also framed to illustrate the hardships of Ice Age life for our ancestors, and the same social forces that still shape human societies: conservatism versus progress, suspicion of novelty, and the struggle to be different in a culture that demands conformity. In both stories, teenage girls must negotiate those pressures and, in doing so, help change the future.

Creationism Refuted - Common Origin Of Human And Other Ape Laughter.

Apes & humans have been sharing a laugh for 15 million years

A stunning example of how science incidentally refutes creationism has just been published in Communications Biology by researchers at the University of Warwick, UK. This is not merely another example of biologists continuing, despite creationist predictions, not to abandon “Darwinism” in favour of creationist magical thinking — the event that creationists have been confidently expecting any day now for more than half a century. It is also a discovery for which evolution provides the obvious and coherent explanation.

Nor is this one easily dismissed by creationists as the result of “The Fall”, Satanic interference, or any of the other routine excuses used when nature refuses to look intelligently designed. Resorting to “common design” merely makes their putative designer god look as though it deliberately created evidence, which is exactly what the Theory of Evolution predicts, apparently in order to mislead us. As Francis Collins pointed out in The Language of God, this image of God as a cosmic trickster is the ultimate admission of defeat for creationists, and shows Young Earth Creationism to be both theologically and scientifically bankrupt.

The shocking thing is how few Christians ever take their co-religionists to task on social media for being prepared to portray their god in this way, rather than having the moral and intellectual integrity to admit that they are wrong. Even their own god is sacrificed on the altar of their implacable vanity.

So, what is this finding by the University of Warwick group?

Quite simply, it is evidence that humans, chimpanzees, bonobos, gorillas and orangutans share a similar rhythmic pattern in laughter, suggesting that this feature was already present in the last common ancestor of all living great apes, including humans, about 15 million years ago. The finding also offers clues to the evolution of human speech.

The researchers analysed laughter recordings from four orangutans, two gorillas, three bonobos, four chimpanzees and four human children. Across 140 laughter bouts, they found the same basic pattern: all species produced laughter with evenly spaced rhythmic intervals between successive sounds. In other words, great ape laughter is not random noise, but has a conserved rhythmic structure.

However, while this basic rhythm has remained remarkably conserved, human laughter has become faster, more variable and more sensitive to social context. Humans are the only great apes in the study shown to vary the timing of laughter according to context — for example, the difference between involuntary laughter when tickled, polite laughter in a social setting, nervous laughter after a mistake, or infectious laughter in a group. This suggests that the increasing ability to control the timing and rhythm of vocalisations may have contributed to the evolution of speech.

A useful way to frame this is that no single feature “proves” common ancestry on its own. The strength of the evidence lies in the way many independent features — anatomy, genetics, development, physiology and behaviour — all point to the same branching pattern of descent.

Malevolent Design - The Complex Mechanism That Helps Bacteria Make Us Sick

Clockwise: A bacterium retracts its pili, reeling in a piece of DNA in the environment. This action facilitates “natural transformation,” a process by which bacterium acquire new genetic traits, including antibiotic resistance.

Image courtesy the Dalia Lab, Indiana University

IU biologists uncover a molecular mechanism that helps bacteria spread antibiotic resistance genes: College of Arts + Sciences : Indiana University

Creationists have a problem of their own making. The same evolutionary processes they try to rebrand as evidence for a creator god are also the processes that produce parasites, pathogens and the molecular machinery by which they exploit their hosts. If Michael J. Behe wants to claim “irreducible complexity” as evidence of design, and William A. Dembski wants to claim “complex specified information” as the signature of an intelligent designer, then they cannot confine those arguments to the parts of biology they find theologically convenient. The same kinds of complexity and genetic information are also found in organisms that make us sick and increase the suffering in the world.

Although professional creationists, including fellows of the Discovery Institute such as Behe and Dembski, are careful to avoid naming their putative designer, their audience invariably identifies it with the supposedly omnibenevolent god of the Bible, Torah and Qur’an. But that creates an obvious problem: using their own criteria, this creator god must be credited not only with designing humans and other animals, but also with designing the bacteria, viruses, parasites and molecular mechanisms that infect, disable and kill them.

The significance of this is often lost on creationists because it requires a basic understanding of biology and a willingness to follow an argument to its logical conclusion. When they cite Behe’s favourite examples, such as the E. coli flagellum or anti-malarial drug resistance in Plasmodium falciparum, as evidence for their god, they are in effect crediting that god with designing mechanisms that help microbes move, invade, survive and evade our attempts to stop them. Point this out, however, and the same evidence that was allegedly scientific evidence for intelligent design is suddenly reinterpreted as evidence for “The Fall” and “Original Sin”. The pretence that creationism is science is abandoned in a hasty retreat into fundamentalist theology, where the same facts are repurposed to reach a more comfortable conclusion.

In addition to the two examples I recently discussed here and here, another example has now been reported — and this one involves a powerful molecular motor that should, by creationist standards, look very much like the sort of thing they would normally call “designed”. It is the type IV pilus retraction system, recently reported in Proceedings of the National Academy of Sciences of the USA (PNAS), which many bacteria use to retract tiny hair-like surface structures called pili. These pili act like microscopic grappling hooks, helping bacteria attach to surfaces and tissues, form antibiotic-resistant biofilms, and pull in fragments of DNA from their surroundings, including genes for drug resistance acquired from other bacteria.

Refuting Creationism - Humans Were Living In A West African Rain Forest 140,000 Years Before 'Creation Week'

Life in a West African rain forest 150,000 years ago

AI-generated image (ChatGPT 5.5 Thinking)

Scientists find earliest evidence that our ancestors lived in rainforests 150,000 years ago | News | The University of Sheffield

Stone Tool

Credit: Jimbob Blinkorn, Max Planck Institute of Geoanthropology

According to the findings of an international team led by the Max Planck Institute of Geoanthropology, with contributions from the University of Sheffield, published in February 2025 in Nature, humans were living in the wet tropical forests of what is now Côte d’Ivoire about 150,000 years ago — more than 140,000 years before creationists imagine their mythical “Creation Week”, when they believe the single ancestral couple of all modern humans was created by magic somewhere in the Middle East.

The date itself is no surprise to anyone who understands the real evolutionary history of our species. Anatomically modern Homo sapiens had emerged in Africa by about 300,000 years ago, and the evidence increasingly points not to a single cradle, but to a pan-African process involving populations adapted to different regions and environments. What is striking about this discovery is not that humans were present in Africa 150,000 years ago, but that they were living in a tropical rainforest — an environment long assumed to have played only a minor, late role in human evolution.

That older assumption fitted neatly with the simplified “savannah hypothesis”, in which the ancestors of humans were thought to have diverged from the lineage leading to chimpanzees and bonobos as climatic change fragmented African forests and created more open grassland and woodland habitats. In that view, rainforest was more of a barrier than a formative environment. But the emerging picture is far more interesting: early H. sapiens were not simply creatures of open savannahs, coasts or grasslands, but members of a flexible, adaptable species able to exploit a wide range of African habitats long before the later dispersals into Eurasia.

Part of the reason rainforest environments have been under-represented in accounts of human evolution is that they are poor places for preserving bones, artefacts and organic remains. Acidic soils, heavy rainfall, dense vegetation and rapid biological decay all work against the survival of the archaeological record. That makes the Bété I site in southern Côte d’Ivoire especially important. Using optically stimulated luminescence and electron spin resonance dating methods, the researchers constrained the onset of human occupation there to around 150 ka. Plant-wax biomarkers, stable isotope data, phytoliths and pollen from the associated sediments then showed that the environment at the time was wet tropical forest.

This pushes the earliest known secure evidence of human occupation of a rainforest environment back by about 80,000 years. It also suggests that tropical forests were not late, marginal or forbidding habitats into which modern humans only ventured after acquiring some special new cultural trick, but part of the ecological range within which H. sapiens was already living during the Middle Pleistocene.

The finding was made possible because modern dating and environmental reconstruction techniques could be applied to sediments associated with stone tools first found at the site in the 1980s. In other words, once again, patient science has extracted a coherent, evidence-based history from the ground — a history that would not exist at all if there had been a recent global genocidal flood churning the world’s sediments into the chaotic mess required by creationist mythology.

Malevolent Design - A Brilliantly 'Designed' Process For Spreading Influenza - Malevolence or Evolution?

Dead cells after the self-destruction and fragmentation process. The large green areas are the “eat me” signals which alert immune cells to kick-start clean-up and recycling process, while the small green circles are the “Footprint of Death” F-ApoEVs left behind by the dying cell.

’Footprint of Death’ gives new clues to cell life, News, La Trobe University

My previous post was about the discovery, reported in Cell Host & Microbe in May 2026, that a single amino-acid change in a coronavirus protein can alter how a bat-related coronavirus interacts with the immune systems of bats and humans. In the case of SARS-CoV-2, the virus that causes COVID-19, such changes help to explain how a virus that may be relatively benign in its natural host can become a serious pathogen when it crosses the species barrier into humans. By creationists' own criteria, this should qualify as intelligent design.

This post concerns another example which, if creationists applied their criteria for intelligent design consistently, would be further evidence of malevolent design. It is the finding, reported in Nature Communications, that influenza A virus can exploit part of the normal process of programmed cell death to help infect neighbouring cells.

Applied consistently, these discoveries would portray creationists' putative designer god as a malevolent entity that designs ways to increase suffering. But, since creationists need to portray this alleged designer as the omnibenevolent god of the Bible, this supposed 'evidence of intelligent design' somehow ceases to be evidence of design at all and becomes evidence of 'Sin' and 'The Fall', as creationists abandon any pretence of science and retreat into Biblical mythology to explain away inconvenient facts.

The discovery, by a team led by PhD candidate Stephanie Rutter in Professor Ivan Poon’s lab at the La Trobe Institute for Molecular Science (LIMS), shows how each step in the process of cell death and renewal is important in helping a dying cell break down and be cleared away by the body’s immune system. The team found that, as cells self-destruct, they change shape, lift away from their surroundings, and leave behind a residue which the researchers dubbed the 'footprint of death'. This contains a previously undescribed type of extracellular vesicle (EV). EVs are small packages used by cells to transport proteins, lipids, DNA and RNA to other cells, acting as an important means of communication between cells.

These new vesicles, known as FOOD-derived apoptotic extracellular vesicles, or F-ApoEVs, normally mark the site of a dead cell and help the immune system identify and clear away the remaining fragments, preventing inflammation and other harmful consequences. But this useful clean-up process can also be turned into a weakness. The researchers found that, when dying cells are infected with influenza A virus, viral proteins and even virus particles can be carried in these F-ApoEVs, providing another route by which infection can spread to neighbouring cells.

Had this process been beneficial to humans, rather than to influenza viruses, creationists would doubtless hail it as a marvel of intelligent design by their god. Yet, because the benefit is to a virus and the result can be disease, suffering and death, the same kind of complexity somehow ceases to count as evidence of design and is quietly reclassified as a mysterious consequence of 'The Fall'.

Creationists get into this bind because they are trying to force the evidence into their preferred mythology. Science has no such problem. The immune system, cell-death pathways and the pathogens that exploit them are all products of evolutionary history, not foresight. They are parts of a continuing arms race in which every useful biological process presents opportunities for parasites, viruses and other pathogens to exploit. An influenza virus that stumbles upon a weakness in a host system does not need to understand it, plan it, or design it; it merely needs to leave more copies of itself than viruses that did not.

Malevolent Design - How SARS-CoV-2 Was Cleverly Designed to Jump From Bats To Humans - Evolution Or Malevolence

A Single Molecular Change May Help Viruses Jump from Bat to Human | UC San Francisco

Two recent papers should delight admirers of creationism's putative intelligent designer, because both show the sort of biochemical ingenuity they normally rush to claim as evidence of design. One, published in Cell Host & Microbe in May 2026 and reported by UCSF in June, shows how a single molecular change can alter the way a coronavirus interacts with bat and human immune systems, helping to explain how viruses related to SARS-CoV-2, the virus that caused the COVID-19 pandemic, can cross the species barrier. The other, published in October 2025 in Nature Communications, which will be the subject of my next blog post, shows how influenza A virus can exploit the remnants of dying cells to help spread infection to neighbouring healthy cells.

However, that excitement is likely to be tempered somewhat when it dawns on them that, if these systems are the products of intelligent design, their designer can only be regarded as malevolent, since the result is an increase in the sum total of suffering in the world. But this does not seem to trouble ID proponents who cite Michael J. Behe's favourite examples — the Escherichia coli flagellum and anti-malarial drug resistance in Plasmodium falciparum — as evidence of irreducible complexity and hence of intelligent design, while ignoring the awkward fact that these supposed examples of design help microorganisms survive, move, infect, or evade human attempts to control them.

This puts creationists in a familiar bind. On the one hand, they like to claim any useful biological complexity as evidence of their Biblical god. On the other, when the same logic points to a designer of pathogens, parasites, immune evasion, drug resistance and viral spread, they retreat into vague claims about 'Sin', 'The Fall', or some mysterious corruption of nature, thereby absolving their god of responsibility for the very mechanisms they were praising as designed only moments earlier.

The first paper, in Cell Host & Microbe, was by a large team of researchers from the University of California San Francisco (UCSF) Quantitative Biosciences Institute, the Icahn School of Medicine at Mount Sinai, the Institut Pasteur and the Fred Hutchinson Cancer Center. It showed that a single amino-acid change in a viral protein can alter how coronaviruses interact with bat and human immune systems, changing the host's response to infection.

Bats are important viral reservoirs because their immune systems and physiology can allow them to tolerate viruses that might cause serious disease in other mammals. They can therefore harbour viruses for long periods, providing opportunities for viral lineages to persist, diversify and acquire mutations that may matter greatly when those viruses encounter a new host species. The UCSF-led study helps to explain how relatively small genetic differences can make the difference between a virus that remains associated with a bat reservoir and one that is better able to evade human immune defences.

This is precisely the sort of thing creationists should, by their own logic, have to call 'complex specified information'. The change is functional; it affects a specific biological outcome; and it is beneficial from the point of view of the viral lineage. The problem, of course, is that creationists usually smuggle in the assumption that 'beneficial' must mean beneficial to humans. If it benefits a virus, a bacterium, a parasite or a cancer cell, they suddenly decide it does not count.

Comparing SARS-CoV-2 with a related bat coronavirus, RaTG13, the researchers found that a viral protein called ORF9b was a key factor. The SARS-CoV-2 and RaTG13 versions of ORF9b are very similar, but behave very differently. In human cells, the SARS-CoV-2 version helped disable an innate immune alarm system, allowing the virus to multiply more effectively. In bat cells, the RaTG13 version interacted with a restriction factor that helped suppress infection.

The team found that changing just one of ORF9b's roughly 100 amino acids reversed its ability to evade the immune response. In creationist thinking, if the phrase is to mean anything at all, this would be new functional genetic information. Yet the actual explanation requires no magic, no designer and no supernatural intervention: a mutation changed an amino acid; that change altered protein interactions; and the result affected viral fitness in different host-cell environments. In other words, ordinary chemistry and physics, operating through mutation, selection and host-virus interaction, produced exactly the kind of functional change creationists insist cannot happen naturally.

The paper in Cell Host & Microbe was accompanied by a news item from UCSF by Levi Gadye:

Refuting Creationism - Observed Evolution In A South African Leopard Population

The elusive Cape leopard.

Jana Ohrner/iNaturalist, CC BY-NC

Leopards adapted to South Africa’s Cape so successfully that they’re genetically unique – study

This paper will have creationists hurriedly trying to redefine evolution so that it no longer means what biologists mean by it — change in allele frequencies in a population over time — but instead becomes some childish parody of the idea, carefully constructed to exclude the scientific definition and so safely miss the point. The paper, published last January (2026) in Heredity, shows that a small, isolated population of leopards (Panthera pardus) in South Africa’s Cape Floristic Region is a striking example of incipient allopatric divergence, and possibly early speciation, in progress. The population, estimated at fewer than 1,000 individuals, has developed a distinctive genome and includes small leopards, some with only about half the body mass of leopards elsewhere in Africa.

In what will also disappoint those creationists who are still eagerly awaiting the abandonment of “Darwinism” by mainstream biologists and its replacement by magic-based creationism, the authors — an international group of leopard conservationists and evolutionary biologists — interpret their findings wholly within the framework of evolutionary theory. By comparing whole-genome data from 43 leopards, including 10 from the Western Cape province (WCP), the team found that the WCP leopards diverged from those of northern South Africa about 20,000–24,000 years ago — in other words, many thousands of years before creationists’ mythical “Creation Week”. They found no obvious evidence that genetic drift alone was responsible for this divergence, and concluded instead that it is more likely to reflect the population’s demographic history, long-term isolation and adaptation to the Cape’s distinctive environmental conditions, including low prey availability.

Their conclusion is that the leopards of the Western Cape can be regarded as an evolutionarily significant unit (ESU): a genetically distinctive population representing a unique component of the species’ evolutionary history and therefore one that should be managed and conserved as such.

One of the team, and first author of the paper, Assistant Professor Laura Tensen of the University of Greifswald, has written an article in The Conversation describing the research and its findings. Her article is reproduced here under a Creative Commons licence, reformatted for stylistic consistency:

Unintelligent Design - The DNA In A Developing Brain Gets Broken And Has To Be Repaired - Incompetent Design Or Evolution?

Neurons migrating through dense tissue in the developing brain (green) frequently undergo DNA damage (magenta).

DNA in neurons is damaged and repaired during brain cortex formation | News | Kyoto University iCeMS

Like my last post, this post illustrates how the human body, far from being the perfect design of the omnipotent, omniscient designer creationists would have us believe in, is the result of a utilitarian evolutionary process. Layers of complexity arise, not from divine brilliance, but from evolved solutions to problems created by suboptimal earlier solutions to other problems — which were themselves the result of imperfect evolution.

In the previous post we saw how DNA replication is sufficiently imperfect that it requires mechanisms to repair the resulting DNA damage. However, these repair processes are themselves potentially dangerous and need control systems to maintain a careful balance between too little and too much repair. When this control process fails, it can lead to cancers that mimic those caused by the BRCA1 and BRCA2 genes, which are associated with increased risk of breast and ovarian cancer.

In this post we see how newborn neurons in the developing brain need to squeeze through tight spaces in dense tissue, past other cells and between fibres, in order to reach their final positions and form neural circuits in the cerebral and cerebellar cortices. This process is such a physical struggle that the DNA in these neurons can suffer double-strand breaks and must be repaired quickly to ensure normal brain development. This is the finding of a research team from Kyoto University, the University of Tokyo, Osaka University, the National University of Singapore and the Tokyo Metropolitan Institute of Medical Science, led by Professor Mineko Kengaku who have just published their findings in Nature.

Mostly, this repair is quick and successful. However, the research team also found striking similarities between the development of mice in which the repair process failed and human genome-instability syndromes that affect the cerebellum.

Another important point is that this repair process appears to be much more successful in damaged neuronal DNA than in similar damage that can occur when some cancer cells migrate through narrow channels. The difference seems to lie in where the DNA breaks occur. In neurons, they tend to occur in regions of the genome that are not actively being transcribed, whereas in cancer cells the damage can involve essential genes. That suggests there is some biological bias in where these breaks occur in neurons, rather than the process being simply random mechanical shattering.

This raises the obvious question for creationists: why create a process that breaks DNA in developing brain cells, only to require another process to repair it, with the inherent risk that the repair process might be incomplete or imperfect? It also raises the possibility that the resulting small differences in the genomes of individual neurons could contribute to neuronal individuality and perhaps to some neurodevelopmental or neurodegenerative diseases.

The emerging picture, from this and from the rogue repair-control process that can mimic cancers caused by the BRCA genes, is not of a human body designed by an omniscient engineer. It is more like a William Heath Robinson contraption: improvised, overcomplicated, dependent on compensatory mechanisms, and always vulnerable to the failure of the very systems needed to keep it working.

Unintelligent Design - What Happens when A Badly 'Designed' Process Goes Rogue - Cancer - Malevolent Design Or Evolution?

Dr. Alexandra Nusawardhana, the lead author of the study and who earned her doctorate in biomedical sciences this year from Penn State College of Medicine, conducts research to understand genomic instability and cancer treatment response.

Credit: Jason Plotkin / Penn State. Creative Commons

DNA repair protein gene gone rogue may unlock new cancer treatments | Penn State University

A characteristic of evolved biological systems, and one that distinguishes them from systems designed from first principles, is that they are often unnecessarily complex, vulnerable to failure and dependent on layers of patchwork compensation. This is what we should expect from systems produced by utilitarian, suboptimal compromises built from whatever was available at the time.

With no plan, no foresight and no predetermined objective, natural selection can only favour whatever leaves more descendants in a particular environment. The result is not an ideal solution, but merely a workable one — one that is better than what preceded it, even if it remains a very long way from perfection. An intelligent designer, such as the one proposed by advocates of intelligent design, would be under no such historical constraints and could, in principle, rebuild a system from scratch to arrive at the optimal solution.

To illustrate this, this post and the next will look at two recent papers that incidentally demonstrate how many human health problems arise from these over-complex, error-prone systems — systems that would not exist if the human body were the pinnacle of created perfection that creationists imagine it to be. Unless, of course, the designer intended us to suffer when its systems failed.

The first concerns a paper published in February 2026 in Nature Communications by researchers at Penn State College of Medicine. It shows how one component of the DNA repair machinery — a system needed because DNA replication and maintenance are themselves vulnerable to error and damage — can itself go wrong and produce a pattern of genomic instability resembling that seen when the BRCA1 and BRCA2 tumour-suppressor pathway is defective.

The culprit is EXO1, a gene that encodes an exonuclease involved in DNA processing and repair. In normal cells, EXO1 helps trim and process damaged or mismatched DNA so that repair can proceed. But when EXO1 is overexpressed, as the researchers found in a significant proportion of several cancers, including about 20–30% of breast and ovarian cancers as well as melanoma, testicular, cervical and hepatobiliary cancers, too much of this normally useful protein becomes destructive. Instead of helping to preserve genome integrity, excessive EXO1 activity can degrade newly synthesised DNA during replication stress, expanding single-stranded DNA gaps and degrading reversed replication forks.

The result is a BRCA-like pattern of genomic instability even in cells whose BRCA pathway is still functional. In other words, the cell behaves in some important respects like a BRCA-mutant tumour cell, not because BRCA1 or BRCA2 is mutated, but because too much EXO1 has overwhelmed the normal protective system. This matters clinically because such tumours may respond to some of the same treatments used against BRCA-mutant cancers, including drugs that target DNA repair vulnerabilities.

So, we have a DNA replication and maintenance system that needs elaborate repair machinery because the genome is constantly vulnerable to damage; then we have the catastrophic consequences when that repair machinery itself goes rogue. Compare that with the simpler, more robust system we might expect from an intelligent designer endowed with foresight and unconstrained by evolutionary history. Complexity is not the hallmark of intelligent design that creationists claim it to be. In biology, it is very often the accumulated consequence of failure-prone, suboptimal compromises produced by evolutionary tinkering without a predetermined objective.

Refuting Creationism - Evolution of Cultivated Cotton - No Magic Required

Wild cotton, on left, has short, brown, and coarse fibers, while modern domesticated cotton has white, fine and abundant fibers. A new study led by Iowa State University scientists identified the northwestern Yucatan Peninsula in Mexico as the original source of domesticated cotton.

Photo: Corrinne Grover/Iowa State University.

Cotton’s roots trace to Yucatan Peninsula, where wild gene pool runs deepest - News Service

My last blog post looked at the evolution of the strawberry and how the evidence of multiple whole-genome duplications and speciation by hybridisation refutes several basic creationist, counter-evidential myths and articles of faith.

This post deals with the evolution and cultivation of the cotton plant, which again refutes the childish notion of divine creation, perfectly suited for use by the creator god's favourite creation, humankind, as well as the creationist article of faith that no new genetic information can arise without the direct intervention of a designer god, because this would supposedly violate the laws of thermodynamics.

As a recent paper in Proceedings of the National Academy of Sciences of the USA (PNAS), by a team of researchers including Professor Jonathan Wendel of Iowa State University, has shown, modern upland cotton, Gossypium hirsutum, is the result of thousands of years of human selection acting on naturally occurring genetic variation. The team traced its domestication to the Yucatán Peninsula in Mexico, probably to the north-western Yucatán, where wild populations still retain the deepest gene pool. Cotton was first domesticated there about 5,000 years ago, which, if creationist chronology were taken seriously, places it before the supposed genocidal global flood, which it appears to have survived along with the people who cultivated it.

The researchers found that domestication transformed a wild, perennial shrub with small bolls and short, coarse, brown fibres into the modern crop with abundant, long, fine, white fibres. This was not the result of a single act of magical design, nor of a sudden, miraculous improvement, but of long-term selection acting on many mutations of relatively small effect, accumulated and filtered over many generations.

The team also showed that, while human selection produced fibres more useful to people, it did so at a cost. Useful traits present in wild populations, such as disease resistance and salt tolerance, were left behind as farmers selected repeatedly from a restricted subset of the original wild gene pool. Each generation of selection narrowed the genetic base still further, pushing cultivated cotton through a genetic bottleneck.

The researchers reached these conclusions by comparing the genomes of cultivated cotton with those of specimens collected from wild populations across the plant's native range. Their analyses showed that domesticated cotton is most closely related to wild cotton from north-western Yucatán, where two random wild plants still show, on average, about twice as much genetic difference as two random modern cultivars.

After cultivated upland cotton spread out of the Yucatán, it eventually became the dominant cotton crop worldwide, displacing or overshadowing other cotton species that had been independently domesticated in South America, Africa and India. Today, Gossypium hirsutum, or upland cotton, accounts for about 90% of the world's cotton crop.