Malevolent Design - How Complex Specified Genetic Information and Irreducible Complexity Cause Pancreatic Cancer

Study reveals protein linked to spread of pancreatic cancer through nerves

A paper just published in Molecular and Cellular Endocrinology shows how precisely the sort of complex specified information and irreducible complexity that Discovery Institute fellows William A. Dembski and Michael J. Behe proclaim as evidence of intelligent design can instead combine to ensure that pancreatic cancer survives, metastasises, and ultimately kills its victims.

This, of course, is true of many diseases, which simply would not exist unless the right combination of genetic information were present and functioning correctly for the disease itself. Yet creationists routinely compartmentalise their beliefs so that harmful “designs” are excluded and blamed on something else, while only those features that appear to benefit humans are credited to a designer.

In the case of parasites, what is harmful to humans is often beneficial to the parasite, but once again the presence of harm causes the logic of creationist arguments to shift. No longer is this evidence of intelligent design, but of something called “sin”, which appears to operate as an autonomous entity capable not only of corrupting creation but of designing living organisms and manipulating their genomes. The formerly omnipotent, omnibenevolent and omniscient designer god now seems strangely impotent, indolent, or indifferent in the face of this alternative “designer”.

This theology also sits uncomfortably alongside another core fundamentalist belief: that God has a plan for everyone, and that everything that happens in a person’s life occurs as part of this divine plan. Presumably, then, that plan must include any diseases they suffer from, including cancer.

It is therefore difficult to see how creationists can escape the conclusion that their god designs and causes cancer as part of this plan, while continuing to cling to the claim that intelligent design is inherently benevolent.

Unintelligent Design - How An Essential Vitamin Helps Cancer Resist Our Immune Response

Ludwig Cancer Research

Recent research has shown that a metabolite of vitamin A, retinoic acid, can quietly inhibit the immune system, making it less responsive to tumours. It also reduces the effectiveness of a promising anti-cancer immunotherapy.

This work, carried out by scientists at the Princeton University branch of the Ludwig Institute for Cancer Research, has resulted in two papers. The first, published in Nature Immunology, describes how retinoic acid produced by the immune system’s dendritic cells (DCs) alters their behaviour, inducing a dangerous tolerance of tumours. The second, published open access in iScience, outlines progress in developing drugs that inhibit retinoic acid production.

To anyone who understands evolution and how it proceeds through a series of sub-optimal “it’ll do” solutions — constrained by what is available at the time and lacking any foresight — it will come as no surprise that the human body’s dependence on vitamin A comes with a downside. These are the inevitable compromises of evolutionary history. What is inexplicable, however, is this vulnerability in terms of intelligent design by an omniscient, omnipotent designer, who should have foreseen such dangers and engineered a better solution — unless, of course, the creation of favourable conditions for cancer was itself part of the design. And that, of course, leads to the theological problems ID creationism leads inexorably to, but ID advocates routinely ignore - a god who is incompetent, indifferent, powerless, or worse still malevolent.

Malevolent Design - How Cancer Perfectly Illustrates ID Creationism's 'Proof' of Intelligent Design

Creationism's God at work

Creationism's intelligent designer creating cancer.

AI-generated image (ChatGPT 5.2).

Dresden research group uncovers new key mechanism in cancer cells | TU Dresden

ID advocates should be thrilled to learn that a team of researchers from Technische Universität Dresden (TUD), Germany, together with colleagues from Charles University, Prague, Czechia, have discovered a perfect example of what Discovery Institute fellows William A. Dembski and Michael J. Behe claim is proof of intelligent design—namely complex specified information and irreducible complexity. The team have just published their findings, open access, in Nature Communications.

There is one slight problem, however: this supposed ‘proof of intelligent design’ turns out to be one of the mechanisms that makes cancer so effective at increasing pain and suffering — and at killing people.

This presents creationists with a theological conundrum. Either there is more than one intelligent designer, which comes close to—or even crosses—the line into blasphemy, or the intelligent designer is actively and knowingly creating a cause of pain and suffering, and is therefore not the omnibenevolent deity portrayed in the Bible.

The stark alternative to these theologically insurmountable problems is equally problematic for ID creationism: admitting that their ‘proof of intelligent design’ is nothing of the sort, and is better explained as the result of a natural process in which no intelligence was involved—thereby absolving their god of any culpability.

The TUD-led team discovered that the protein MCL1 not only inhibits programmed cell death, or apoptosis, but also plays a central role in tumour metabolism. Normal, non-cancerous cells will usually self-destruct if their DNA becomes corrupted beyond repair, but when this process fails, a tumour can develop through the proliferation of cells carrying damaged DNA. In cancers, this self-destruct mechanism is suppressed by MCL1.

The team also found that MCL1 is not only responsible for preventing apoptosis, but also dysregulates cellular energy metabolism. In other words, a single factor ensures both cancer cell survival and the functioning of key metabolic and signalling pathways for the benefit of the tumour.

In Michael J. Behe’s terms, all the components of this survival mechanism must be present for the cancer to persist; and in William A. Dembski’s terms, the genetic information coding for MCL1 must constitute highly specified complex information.

Incompetent Design - Failing To Plan Is Planning to Fail - And A Fatal Cancer Is The Result

Stress

Chronic stress and obesity work together to accelerate pancreatic cancer development and growth, study finds | UCLA Health

It’s a fundamental principle of management that failing to plan is, in effect, planning to fail. The future is inevitable, so preparation for it is essential.

Creationism’s supposed designer, however, is claimed to be both omniscient and omnipotent — fully aware of the future and capable of shaping it. In fact, many fundamentalist believers assert that this designer has a specific plan for each individual, meaning it doesn’t just foresee the future but actively creates it.

Logically, then, an intelligent, all-knowing creator should have planned accordingly, yet the evidence suggests otherwise. Our bodies are poorly adapted to endure the demands of modern urban life in a technologically advanced society, indicating a lack of foresight in their design.

The alternative explanation? This designer was fully aware of our future needs but deliberately created a body ill-suited for them.

Malevolent Design - How Creationism's Divine Malevolence Co-opted A Solutions For It's Own Incompetence, To Ensure Cancers Survive

The Pol-θ enzyme (blue) joins two parts of a broken DNA strand (yellow).
This process is mutagenic and can give rise to cancer.

Credit: Scripps Research

How a crucial DNA repair protein works—and what it means for cancer treatment | Scripps Research

According to creationist mythology, once upon a time a magic creator created animal life complete with DNA which needs to be replicated every time a cell divides for growth and/or repair.

Unfortunately, the process it designed to make this happen wasn't very well designed, so the resulting DNA is often broken or faulty. DNA can be broken in a number of ways, all of which could have been avoided by a more robust design, which should have been within the capabilities of an omniscient deity, capable of creating living organisms ex nihilo:

DNA double-strand breaks can occur in multiple phases of the cell cycle, not just mitosis. While replication stress is a major endogenous source, environmental factors like radiation, chemicals, and viruses can also introduce DSBs. Cells rely on homologous recombination (HR), non-homologous end joining (NHEJ), and alternative end joining (alt-EJ) to repair these breaks, though error-prone pathways like Pol θ-mediated repair contribute to mutagenesis.

Then, in a method typical of creationism's incompetent designer, which in every respect resembles a mindless utilitarian natural process, proceeding without a plan and settling for suboptimal solutions, it added yet another layer of complexity as a work-around for its failure, and designed the enzyme, polymerase θ (Pol-θ), which searches the DNA looking for faults. Unfortunately, due to suboptimal design, this too fails and produces cancers.

Malevolent Designer News - How Brain Cancer Turns Our Immune System Against Us

The Wistar Institute Discovers a Promising Target in Brain Cancer - The Wistar Institute

It's an old trick often used by creationism's divine malevolence to turn a host's immune system against it and instead work for the parasite.

And, according to a discovery by researchers at the Wistar Institute, this is exactly what one of the most aggressive forms of brain cancer does by reprogramming the white blood cells known as neutrophils, so they supress any further immune response to the cancer.

Of course, whether you accept that or not depends on whether you've fallen for the disinformation promulgated by Deception Institute fellows such as William A Dembski and other leading apologists for the intelligent design cult. Dembski, for example, promotes the notion that genes which produce any given functional protein only do so if they've been given 'complex specified information' to enable them to produce that particular protein.

His presuppositional circular reasoning goes something like, the output from a gene must have been intentional and intent implies sentience, so an intelligent designer must have supplied the information in order to achieve a desired outcome. This of course ignores the fact that mutation and selection occurs in a gene pool consisting of millions of cells and not as a single event in a single cell. In a population of a million cells, the million to one chance mutation arises on average once every cell generation.

A cancer, which is a collection of cells in a hostile environment, can evolve by natural selection to survive and replicate in that environment, so the outcome will depend on the result of an evolutionary arms race.

But, using Dembski's self-referencing logic, believers in intelligent design have to accept that the 'complex specified information' that enables brain tumours to reprogram neutrophils and so supress the immune system, must have been provided by an intelligent designer to achieve exactly that result, because, so he wrongly argues, mutation and natural selection alone can't produce a strategy for survival.

The bad news for supporters of Dembski's divine malevolence is that the discovery by researchers at the Wistar Institute may have tipped the balance in the arms race between human medical science and the malevolent designer in favour of human medical science, in that it suggests a form of treatment for this type of brain cancer.

Malevolent Designer News - How Bowel Cancer Is Designed To Outwit Our Imune System

Example hematoxylin and eosin (H&E) staining for polypoid cancer

Kayhanian, H., Cross, W., van der Horst, S.E.M. et al. (2024)

Bowel cancer turns genetic switches on and off to outwit the immune system | UCL News - UCL – University College London

You're creationism's favourite invisible designer and you want to make people suffer and die from bowel cancer. So, you design a tumour that grows, spreads, and destroys essential tissues and systems. All good so far.

But there is a problem: when you designed humans you gave them an immune system to protect them from the parasites you had designed to make them sick, and this immune system can detect the bowel cancer cells and kill them!

What do you do?

Well, obviously, you design the cancer cells so they outwit the immune system you designed, and since you designed it, you know exactly what its weaknesses and vulnerabilities are.

Easy peesy! You just design the cancer cells so they switch the immune system off!