Trump's Chickens May Be Coming Home to Roost - Carrying H5N1 Bird Flu

AI-generated image (ChatGPT 4o)

Americans don’t think bird flu is a threat, study suggests - CUNY Graduate School of Public Health & Health Policy

Elephant seals, killed by H5N1 'bird flu' on an Argentine beach.

Ralph Vanstreels, (UC Davis).

In the early days of the COVID-19 pandemic, President Donald Trump panicked when he realised that, in his eagerness to undo everything associated with Barack Obama, he had dismantled critical contingency plans for dealing with pandemics and allowed the national stockpile of personal protective equipment (PPE) to fall into disrepair. These actions left the United States ill-prepared for a public health crisis of such magnitude. Trump and his cronies promptly went into damage-limitation mode, i.e., blame everyone else (the buck stops over there!)

Rather than accepting responsibility, Trump—seemingly incapable of admitting error—chose to downplay the severity of the virus, which he referred to as the "Chaynees Vayrus". He repeatedly told Americans that COVID-19 was a mild illness that would "disappear" with the arrival of warmer weather in April (New York Times, 2020; Washington Post, 2020.1), ignoring both scientific advice and the obvious fact that seasonal changes vary globally, and that high temperatures do not neutralise the SARS-CoV-2 virus (WHO, 2020.2).

Having politicised the pandemic from the outset, Trump targeted public health officials such as Dr Anthony Fauci, whose science-based guidance often contradicted the president’s misleading statements (Science, 2020.3). Trump further encouraged scepticism toward basic mitigation measures such as social distancing, avoiding large gatherings, and wearing face masks. As a result, the wearing of masks was quickly stigmatised by many on the political right in the United States as a symbol of liberal or left-wing allegiance (Nature Human Behaviour, 2021). The consequences were stark: the White House itself became a hotspot for infections (BBC, 2020.4), and Trump’s campaign rallies became notorious super-spreader events (CDC Morbidity and Mortality Weekly Report, 2021.1).
And the death toll in the USA was the highest by far of any developed nation, and higher than almost all under-developed economies with rudimentary health services¹.

This cultivated scepticism was eagerly adopted and amplified by conspiracy theorists within the Trump-supporting QAnon movement. A flood of increasingly absurd claims followed, including that the pandemic was a hoax, that vaccines contained nanotechnology to allow government tracking via Bill Gates, and even that the vaccines could alter DNA to change an individual’s sexual orientation (MIT Technology Review, 2021.2; Pew Research Center, 2020.5).

Underlying this environment of mistrust was a population that had, for decades, been influenced by creationist front groups such as the Discovery Institute. These organisations have consistently worked to undermine public confidence in science, promoting the narrative that science is a conspiracy by a secretive elite seeking to destroy spiritual values and replace "Christian America" with a secular, left-leaning "Darwinist" society (Forrest & Gross, Creationism's Trojan Horse, 2004; Branch & Scott, National Center for Science Education, 2009).

Unintelligent Design - The Design Defect That Can Cause a Cleft Palate - Incompetence, Malevolence or Evolution?

Medical science corrects a design defect.

Source

New study reveals how cleft lip and cleft palate can arise | MIT News | Massachusetts Institute of Technology

In my book, The Body of Evidence: How the Human Body Refutes Intelligent Design, I present numerous examples demonstrating that the human body is not the product of intelligent design, but rather the outcome of an evolutionary process characterised by compromises and suboptimal solutions. Evolution is constrained by what it has to work with and must continually balance competing demands—for instance, short-term reproductive success versus long-term health and well-being, which often contribute little or nothing to the long-term propagation of genes.

The result is an error-prone and overly complex system built upon earlier suboptimal compromises. This complexity gives rise to the many defects and medical problems to which humans are prone—problems that would not exist if the human body were the creation of an intelligent and benevolent designer, such as the deity posited by creationist belief systems. Such a deity would surely have designed a body so robust that there would be little need for a medical profession, save perhaps for treating accidental trauma. The very existence of hospitals and medical science stands as a testament to the failure of the human body's design to approach anything resembling the perfection many creationists claim.

Now, researchers at the Massachusetts Institute of Technology (MIT) have identified yet another example of this flawed complexity: a defect in transfer RNA (tRNA) linked to babies being born with a cleft lip and palate. The defect lies in the DDX1 gene, which is essential for proper tRNA function. Without it, tRNA cannot deliver amino acids to ribosomes to synthesise proteins. In the absence of this crucial process, the cells that form the upper lip and the roof of the mouth cannot fuse correctly during development.

The findings, by a team led by Michaela Bartusel, are published in The American Journal of Human Genetics.

Malevolent Design - Why Did Bats Get a Better Immune System Than We Did?

A Carollia perspicillata bat from a colony that had been maintained at WSU Vancouver.

Photo: WSU

Seba's short-tailed bat, Carollia perspicillata

By Desmodus - Own work, CC BY-SA 4.0, Link

Bat cells could aid in fighting humans’ most deadly diseases | WSU Insider | Washington State University

Creationists assert that humans are the special creation of their designer god, placing humanity at the pinnacle of 'creation'. Even those theists who accept the Theory of Evolution but believe it was guided by God with humans as the intended ultimate outcome, regard humanity as their deity's supreme achievement.

If this claim were accurate, it would be reasonable to expect humans to possess the optimal anatomical and physiological characteristics across all biological systems. In reality, numerous species exhibit superior traits and abilities compared to humans—traits which, had they been bestowed upon humans, would have significantly improved our wellbeing and survival capabilities.

For instance, birds have a respiratory system far superior to mammals, including humans, enabling efficient oxygen exchange during flight. Raptors possess remarkable eyesight, allowing them precise vision at speeds that would render nearby objects a mere blur to human vision. Elephants, sharks, and naked mole rats exhibit extraordinary resistance to cancer. Furthermore, many mammals experience lower perinatal mortality rates than humans even with modern medical intervention.

As highlighted in a recent study published in PLOS Biology, bats tolerate viral infections that are often fatal to humans, so they can harbour evolving viruses that, when they find their way into humans, can result in serious pandemics such as the recent COVID-19 pandemic.

If we entertain the creationist argument, their purported intelligent designer had already perfected these advantageous traits in other species. Yet, paradoxically, humans were deprived of these beneficial adaptations. This scenario suggests a designer whose decisions could only be interpreted as either incompetent or malevolent. It is the equivalent of a car manufacturer having designed a super-efficient, low-emission and cheap engine in one of its models, continuing to fit an old, expensive, wasteful and polluting engine to its top of the range model.

However, the evolutionary explanation — that different species evolved distinct traits adapted specifically to their environmental pressures — fully clarifies why humans possess adequate but not necessarily optimal traits. Unfortunately for creationists, adherence to their dogma forces them to dismiss this rational explanation, instead endorsing a narrative that inadvertently portrays their intelligent designer as either incompetent, malevolent, or potentially both.

That bats have superior immune system to humans has long been known, but why that is in terms of their cell physiology is still something of a mystery. Now, however, a team of researchers led by Washington State University molecular virologist Michael Letko has developed two lines of bat cell cultures which can be used to study how their immune system responds to different viruses, for example, the ebola virus, with a view to utilising that information to treat infections in humans.

Their findings are the subject of a research paper in PLOS Biology and are explained in a Washington State University (WSU) news item:

Malevolent Design - How Dembski's 'Complex Specified Information' Causes Acute Myeloid Leukemia

Rapid growth of blood cancer driven by a single genetic ‘hit’

William A. Dembski’s concept of complex specified information (CSI) remains ambiguous—arguably by design. His use of the word specified is particularly opaque: is he referring to information that produces outcomes he wishes his readers to believe are purposeful and intelligently designed by a particular deity, or is the term intended to encompass any genetic information that results in any outcome—beneficial, neutral, or harmful?

Taken at face value, and in the absence of a clear, testable definition, there appears to be no reason Dembski’s concept could not apply to information that is ultimately detrimental, either to the organism itself, or to another organism in the case of parasites or cancer. Why, for instance, should we conclude that the complex information in a gene enabling the expansion of the human brain and the enhancement of cognitive function was specified, but that the equally complex genetic information enabling a cell to become a malignant cancer, or allowing the Plasmodium falciparum parasite to evade anti-malarial drugs, was not also specified by the same intelligent designer?

Given that Dembski is a senior fellow of the Discovery Institute — an organisation notorious for its Wedge Strategy, which seeks to undermine public trust in science through disinformation and misrepresentation while promoting creationism under the guise of scientific legitimacy — it is unsurprising that complex specified information remains a nebulous and ill-defined term. The strategy’s aim has never been to engage in genuine scientific discourse or subject its claims to critical scrutiny, but rather to advance a religious agenda while avoiding the accountability that comes with reasoned analysis and empirical testing. A cynic might conclude that the leading ID advocates know their claim has no scientific basis but want their target audience to believe otherwise.

So, I invite Intelligent Design creationists to explain why the recent discovery of a gene that promotes the rapid early development of acute myeloid leukaemia should not be an example of Dembski's 'complex specified information' and so evidence that Dembski's intelligent designer designed acute myeloid leukaemia, or whether Dembski's term is deliberately vague so as to appeal to people looking for confirmation of existing bias.

Unintelligent Design - If Scientists Can Do It, Why Can't an Intelligent, Omnipotent Designer - If It Wanted To?

Treatment for mitochondrial diseases within reach | University of Gothenburg

If the human body had truly been intelligently designed by an omnibenevolent, omniscient deity, it would operate flawlessly under all conditions, free from the compromises and constraints inherent in evolutionary history.

Were this the case, much of modern medicine would be unnecessary, limited perhaps to the management and repair of traumatic injuries. Parasites, should they exist at all, would be effortlessly repelled by a perfect immune system. Genetic and structural defects, such as hernias, atherosclerosis, autoimmune disorders, blindness, deafness, neurodegenerative diseases, and complications in childbirth would simply not occur.

However, as I showed in my book, The Body of Evidence: How the Human Body Refutes Intelligent Design, the human body is not the product of intelligent design; it has evolved through a process marked by trial and error, adaptation to existing structures, and the utilitarian pressures of survival and reproduction. This explains the vast array of medical conditions that keep healthcare systems busy, often stretched to their limits. It also drives the extensive scientific research dedicated to discovering the causes and developing cures for various illnesses—achievements that an omnipotent and omnibenevolent creator, if one existed, presumably would have provided already.

Recent news highlights this contrast starkly. Scientists may have discovered a groundbreaking cure for a rare mitochondrial disease caused by mutations in the POLG gene, a condition that leads to severe disability or even early death. This advancement prompts a critical question for creationists: If human scientists can find solutions to such devastating genetic problems, why can't—or won't—your purported intelligent designer? And perhaps, more to the point, why was this defect designed in the first place?

Malevolent Designer News - How Monkeypox Is Being Redesigned to Infect More People

Mpox could become a serious global threat, scientists warn | University of Surrey

Science has just dealt creationism another body blow.

Researchers from the University of Surrey, UK, have demonstrated that the monkeypox virus has undergone a mutation that enhances its ability to spread more readily from person to person through direct contact. This increased transmissibility raises the concern of a potential global pandemic.

Since this mutation confers a benefit to the virus, it aligns with William A. Dembski's concept of 'specified complexity', which he uses to argue for intelligent design. By extension, Dembski’s argument suggests evidence of an intelligent designer, whom his intended audience typically identifies as the Christian God.

However, because the mutation has resulted in a greater prevalence of the mutated form of the virus compared to non-mutated forms, this clearly demonstrates evolution through natural selection. Consequently, it contradicts the notion of 'devolution' proposed by Michael J. Behe, who suggests that parasites and pathogens represent biological deterioration rather than adaptive evolution.

Therefore, the new variant of the monkeypox virus presents either evidence supporting creationism's deity — which would imply intentional creation of viruses specifically designed to cause illness—or clear evidence supporting evolution through natural selection.

Unintelligent Design - How The Badly-Designed Immune System Destroys Lungs

Scientists Discover Immune Cell Networks Driving Deadly Lung Disease | Rutgers University

Autoimmune conditions and allergies provide strong evidence for evolution over intelligent design by highlighting the imperfections and trade-offs inherent in the immune system. These disorders demonstrate how a system shaped by natural selection can prioritize short-term survival at the expense of long-term health, leading to vulnerabilities that are difficult to reconcile with the concept of a perfect designer.

Autoimmune diseases occur when the immune system mistakenly attacks the body’s own tissues. Examples include rheumatoid arthritis, lupus, multiple sclerosis, and type 1 diabetes.

The immune system must strike a delicate balance: it must be reactive enough to fight infections but tolerant enough to avoid attacking the body’s own cells. Evolution has shaped this balance, but it is imperfect. A hyperactive immune system, while better at combating infections, increases the risk of autoimmune diseases.

The Body of Evidence: How the Human Body Refutes Intelligent Design pp. 129-130

Now it's beginning to look like we must include the fatal lung disease known as idiopathic pulmonary fibrosis (IPF) to the long list of autoimmune conditions that stem directly from the facts that the immune system evolved and was not intelligently designed.

The very existence of the immune system should prompt creationists to reconsider several basic beliefs and especially claims made by leading proponents, such as Michael J. Behe. Behe suggests that pathogens and the diseases they cause result from 'genetic entropy', a degradation enabled by biblical 'Sin', which supposedly causes genomes to 'devolve', thus creating parasites and pathogens. Other creationists suggest an alternative viewpoint, attributing the existence of parasites and diseases to an evil designer, such as Satan - a claim which is regarded as blasphemous by fundamentalists for whom it is doctrine that there is only one creative entity - God.

In contrast, William A. Dembski argues that any 'complex specified information' (CSI) within the genome must originate from an intelligent designer, typically inferred — though seldom explicitly acknowledged by prominent creationists — as the God described in the Bible or the Qur'an. The genes that enable parasites to evade our immune defences are clear examples of what Dembski would term CSI, whereas Behe regards these genes as 'devolved' from an initially perfect creation.

However, neither Behe nor Dembski adequately addresses the question of who or what designed the immune system itself. Was it the same designer responsible for Dembski's complex specified information, or was it Behe's designer of an initial, perfect creation? If we consider Dembski's argument, it raises a critical question: where is the intelligence in designing an immune system to protect organisms against pathogens created by the very same designer? Regarding Behe's perspective, if the immune system were part of the initial perfect design, why would the designer anticipate 'The Fall' and its consequences unless it was intentionally planned? Alternatively, did all organisms possessing immune defences receive an upgrade after 'The Fall', indicating a supposedly omniscient deity initially failed to foresee the need for such protection? This then raises the question, is the designer either not omniscient or not competent, or did it plan for the 'Fall' and the suffering caused by parasites all along?

Not only are there these gaping flaws in creationism's attempts to account for the immune system within their own theology, including its failure to protect us and its propensity to attack us because the delicate balance referred to above is not robust enough or sensitive enough. The fact is that a perfectly designed immune system should make much of medical science redundant. However, the evidence continues to accumulate that the immune system, like the rest of biology is not the result of intelligent design but of an evolutionary process with all its inherent faults, constraints and inevitable suboptimal compromises.

Evidence strongly supporting the theory that IPF is the result of an autoimmune response by an over-sensitive immune system has been provided by a team of researchers led by Rutgers University, New Jersey, USA. Their findings are being published in the European Respiratory Journal and are described in Rutgers Today:

Refuting Creationism - Students Discover How The Mammalian Immune System Evolved.

Nebraska undergrads uncover ancient secrets of human immunity | Nebraska Today

(C–F) Expanded views of the interaction interface between STAT2 CCD and IRF9 IAD for mouse (C), human (D), Hypanus sabinus (E), and Stegostoma tigrinum (F). The interactions are observed in the crystal structure of the mouse STAT2-IRF9 complex (PDB ID: 5OEN) [19.1]. For humans and the two cartilaginous fishes, the interactions are based on the modeled structures of the STAT2-IRF9 complex. The key residues involved in the interface are labeled. The phenylalanine (F) on the STAT2 protein is colored in green. The four residues forming the cleft on the IRF9 protein are colored in magenta. The corresponding sequences of the interface area and other details are found in Supporting Information S1: Figure S3.

Recent research conducted by undergraduate students at the University of Nebraska–Lincoln has provided compelling insights into the evolutionary development of the human immune system. Under the guidance of Professor Luwen Zhang, students Vanessa Hubing, Avery Marquis, and Chanasei Ziemann co-authored two significant studies published in the Journal of Medical Virology. Their work elucidates the progression of immune regulatory mechanisms in vertebrates, highlighting the transition to more complex systems with the evolution of jaws. Additionally, they explored how a pseudogene, potentially introduced into primate DNA via a retrovirus approximately 60 million years ago, may have enhanced ancestral immune responses.

These findings offer robust evidence supporting the theory of evolution by demonstrating the gradual and adaptive changes in genetic material that have led to sophisticated immune functions in humans. The identification of a pseudogene's integration into primate DNA and its subsequent role in immunity exemplifies natural selection's influence on genetic composition over millions of years. Such evidence challenges creationist perspectives by providing concrete examples of evolutionary processes shaping complex biological systems, underscoring the dynamic nature of genetic evolution in response to environmental pressures.

During the course of evolution, these factors have evolved as additional layers of complexity to improve and refine a system which, as the product of an unplanned, utilitarian evolutionary process was a suboptimal compromise between the tendencies to over-react to some infections and fail to respond to others. An intelligently-designed sytem would need no such regulatory mechanisms. This is how we can tell that such overly-complex systems were not intelligently designed.

The Unintelligent Designer - Another Error-Prone Bungle to Compensate for a Bungled Design

William Heath Robinson

Peacekeeper cells protect the body from autoimmunity during infection | Biological Sciences Division | The University of Chicago

A significant issue with our immune system is that it is poorly "designed." If it were truly the product of an intelligent designer, as creationists claim, that designer would hardly be competent enough to design a simple household item, let alone a complex biological system.

Because our immune system is so disorganized and inefficient, multiple layers of complexity have evolved to mitigate its worst shortcomings. However, these added layers themselves remain prone to errors, as they reflect the same flawed foundation. The central problem arises because the immune system must balance two contradictory requirements: it needs to be sensitive enough to identify and eliminate genuine threats, yet not so sensitive that it mistakenly attacks the body's own tissues.

While an omnipotent, supremely intelligent designer should have easily resolved such a contradiction, the reality is that our immune system frequently fails on both counts. It often permits pathogens and parasites to invade, and it also frequently turns against the body itself, leading to autoimmune diseases such as lupus, diabetes, multiple sclerosis, arthritis, and kidney or liver failure, among numerous other debilitating conditions that cause immense suffering.

Like the whimsical contraptions created by cartoonist William Heath Robinson — complex machines built from objects originally intended for entirely different purposes - the mammalian immune system is not designed top-down from a clear blueprint. Rather, it's built up gradually from one makeshift adaptation piled onto another, each new solution attempting to compensate for the shortcomings of earlier ones. Eventually, this process results in a ramshackle system so intricate that its complexity itself creates new opportunities for failure. Such complexity is not indicative of intelligent, purposeful design, which would typically favour simplicity and efficiency. Instead, it reflects an ad hoc, utilitarian approach driven by evolutionary constraints and an inability to anticipate future challenges.

And of course, this embarrassment for creationism is made worse by the fact that, according to Michael J. Behe, pathogenic parasites such as E. coli and Plasmodium falciparum are examples of irreducible complexity, so are, in creationist circles, unarguable 'proof' of intelligent design, so the immune system is allegedly designed by the designer of these pathogens to protect us from them.

It seems creationists have no difficulty in believing the same designer would design parasites to make sick, then design a system to protect us from its pathogenic designs, and even though that system doesn't work very well, it is nevertheless evidence of supreme intelligence.

Refuting Creationism - How Chimpanzees Have Evolved For Different Parasites, Including Malaria

Mother and baby chimpanzee in Uganda.

Kevin Langergraber, The Ngogo Chimpanzee Project.

Chimpanzees are genetically adapted to local habitats and infections such as malaria | UCL News - UCL – University College London

It can't be easy making a living as a creationist grifter when science continually undermines your claims, exposing your misrepresentation of evolutionary biology and eroding your credibility — even among the faithful supporters you count on to pay for confirmation of their biases. It must be a relief that your target will rarely, if ever fact check your claims, making them easy victims of your disinformation.

So, you can take comfort in the fact that none of your marks will read this piece of research that shows how chimpanzees are closely related to humans and have evolved over time to adapt to a number of different environments, much the way the ancestors of modern humans adapted when their environment changed from forest to savannah, some 6 million years ago.

Included in the study is how chimpanzees, who have been suffering from malaria for much longer than humans, humans having acquired their most deadly species of the plasmodium parasites from chimpanzees only some 300,000 years ago and possibly as recently as 50,000 years ago, have evolved resistance to the parasite so they now show almost no signs of infection.

Malevolent Design - How a Design Blunder Caused Parkinson's Disease - Or Was It Malevolence?

Two PINK1 proteins are shown attached to the membrane of a mitochondrion for the first time.

Scientists solve decades-long Parkinson’s mystery | WEHI

One of the causes of Parkinsonism is the accumulation of defective mitochondria in neurone leading to the death of these cells and reduced neurotransmitter production. Under normal circumstances, a protein known as PTEN-induced putative kinase 1 (PINK1) attaches to the surface of damaged mitochondria and facilitates their destruction, but when a mutation causes PINK1 to malfunction, this cell hygiene mechanism fails.

The question for creationists is why this cell hygiene process is needed in the first place when an intelligent designer could have designed more robust mitochondria, and why does it depend on an error-prone process where a simple mutation is the gene for a key protein can cause the whole thing to fail?

In fact, of course, what we have here is an example of a layer of complexity being necessary because a fundamental process is suboptimal, when a well-designed process would need no such additional layer of complexity. Additional complexity simply multiplies that opportunity for failure, especially when the additional complexity is itself suboptimal.

As an example of putative intelligent design, the result is exactly what we would expect a mindless, unintelligent process to produce.

Malevolent Design - The Sneaky Way The Epstein-Barr Virus Can Cause Multiple Sclerosis

The Epstein-Barr virus (EBV)

Image: Getty Images

The Epstein-Barr virus (EBV) is very common and can cause glandular fever in young adults.

Image: Getty Images

Genes combined with immune response to Epstein-Barr virus increase MS risk | Karolinska Institutet

To believe in the childish notion of intelligent design by an omniscient, magical designer is to believe two things:

• That it created our shoddy immune system that not only fails to protect us from pathogenic organisms such as bacteria, fungi and virus that frequently infect us.
  
• That it also designed those pathogens and gave them the ability to not only evade our immune system but also turn it against us to ensure we suffer the long-term effects of infections, even when we have eliminated the causative parasite from our bodies.

In other words, creationism is to believe the putative designer is incompetent and/or malevolent.

Malevolent Designer News - How Tuberculosis Is Protected During Airborne Transmission

This article is best read on a laptop, desktop, or tablet

Scientists have discovered a family of genes that becomes essential for survival specifically when the tuberculosis pathogen is exposed to the air, likely protecting the bacterium during its flight.

Image: iStock; MIT News.

Study: Tuberculosis relies on protective genes during airborne transmission | MIT News | Massachusetts Institute of Technology

Imagine you're the designer of a nasty little pathogen that is designed to make people sick and die, but you have a problem. The organism needs to get from one victim to the next in order to spread and make as many people sick as possible, but, as an obligate pathogen, it is designed to life in the moist warm interior of its victims, so is not very good at living outside, where it needs to be, if only briefly, to get into its next victim.

Quite a problem, eh?

But not something beyond creationism's divine malevolence, it seems, because, if you accept creationists' argument for the moment, the parasitic organism that causes tuberculosis is specially designed to survive while in transit, so to speak.

Exactly how it does it has recently been discovered by researchers at the Massachusetts Institute of Technology (MIT) and their collaborators. The key to its survival is a family of genes that were previously believed to be non-essential because they had no effect when injected into a potential host but have now been shown to be essential for survival outside a host's body.

Incompetent Design - Failing To Plan Is Planning to Fail - And A Fatal Cancer Is The Result

Stress

Chronic stress and obesity work together to accelerate pancreatic cancer development and growth, study finds | UCLA Health

It’s a fundamental principle of management that failing to plan is, in effect, planning to fail. The future is inevitable, so preparation for it is essential.

Creationism’s supposed designer, however, is claimed to be both omniscient and omnipotent — fully aware of the future and capable of shaping it. In fact, many fundamentalist believers assert that this designer has a specific plan for each individual, meaning it doesn’t just foresee the future but actively creates it.

Logically, then, an intelligent, all-knowing creator should have planned accordingly, yet the evidence suggests otherwise. Our bodies are poorly adapted to endure the demands of modern urban life in a technologically advanced society, indicating a lack of foresight in their design.

The alternative explanation? This designer was fully aware of our future needs but deliberately created a body ill-suited for them.

Malevolent Design - How Creationism's Divine Malevolence Co-opted A Solutions For It's Own Incompetence, To Ensure Cancers Survive

The Pol-θ enzyme (blue) joins two parts of a broken DNA strand (yellow).
This process is mutagenic and can give rise to cancer.

Credit: Scripps Research

How a crucial DNA repair protein works—and what it means for cancer treatment | Scripps Research

According to creationist mythology, once upon a time a magic creator created animal life complete with DNA which needs to be replicated every time a cell divides for growth and/or repair.

Unfortunately, the process it designed to make this happen wasn't very well designed, so the resulting DNA is often broken or faulty. DNA can be broken in a number of ways, all of which could have been avoided by a more robust design, which should have been within the capabilities of an omniscient deity, capable of creating living organisms ex nihilo:

DNA double-strand breaks can occur in multiple phases of the cell cycle, not just mitosis. While replication stress is a major endogenous source, environmental factors like radiation, chemicals, and viruses can also introduce DSBs. Cells rely on homologous recombination (HR), non-homologous end joining (NHEJ), and alternative end joining (alt-EJ) to repair these breaks, though error-prone pathways like Pol θ-mediated repair contribute to mutagenesis.

Then, in a method typical of creationism's incompetent designer, which in every respect resembles a mindless utilitarian natural process, proceeding without a plan and settling for suboptimal solutions, it added yet another layer of complexity as a work-around for its failure, and designed the enzyme, polymerase θ (Pol-θ), which searches the DNA looking for faults. Unfortunately, due to suboptimal design, this too fails and produces cancers.

Malevolent Designer News - The Clever Way The Herpes Virus Gets Reactivated

UVA IDs Trigger for Those Annoying Cold Sore Flare-ups

The herpes viruses are ingenious designs of creationism's divine malevolence which are highly infectious and, once infected, you have them for life.

Of course, there is no point in designing a virus to just live inside its hosts cells doing nothing to increase the suffering in the world, so they come with a number of responses to various triggers which cause them to proliferate and start infecting other people.

Since these abilities are undoubtedly beneficial to the virus, there is no rational way that this can be presented as 'devolution' from some assumed created perfection - the forlorn attempt by Michael J. Behe to excuse the Christin god from culpability for parasites.

However, William A. Dembski, another Deception Institute Fellow, claims that anything which a gene produces must have been specified by an intelligent designer, so followers of the ID cult are obliged by dogma to give credit to their preferred creator deity for the herpes virus.

Now researchers at the University of Virginia have discovered a surprising way in which herpes can be reactivated, and, true to creationism's divine malevolence's form, it takes advantage of the hosts response to other infections and rides piggy-back on the hosts immune system - an immune system the same alleged designer designed to protect us from the viruses it designed to make us sick (if you believe that childish superstition).

The Herpes virus can respond to a protein produced by cells subject to stress which normally activates the immune system. However, the herpes virus is reactivated and starts producing lots of new virus particles, so the sufferer becomes infectious again and infects lots of other people. Then, job, jobbed, the herpes virus goes back into hiding to wait for the next chance to be reactivated and begin to replicate again, often many years later.

Malevolent Designer News - How Brain Cancer Turns Our Immune System Against Us

The Wistar Institute Discovers a Promising Target in Brain Cancer - The Wistar Institute

It's an old trick often used by creationism's divine malevolence to turn a host's immune system against it and instead work for the parasite.

And, according to a discovery by researchers at the Wistar Institute, this is exactly what one of the most aggressive forms of brain cancer does by reprogramming the white blood cells known as neutrophils, so they supress any further immune response to the cancer.

Of course, whether you accept that or not depends on whether you've fallen for the disinformation promulgated by Deception Institute fellows such as William A Dembski and other leading apologists for the intelligent design cult. Dembski, for example, promotes the notion that genes which produce any given functional protein only do so if they've been given 'complex specified information' to enable them to produce that particular protein.

His presuppositional circular reasoning goes something like, the output from a gene must have been intentional and intent implies sentience, so an intelligent designer must have supplied the information in order to achieve a desired outcome. This of course ignores the fact that mutation and selection occurs in a gene pool consisting of millions of cells and not as a single event in a single cell. In a population of a million cells, the million to one chance mutation arises on average once every cell generation.

A cancer, which is a collection of cells in a hostile environment, can evolve by natural selection to survive and replicate in that environment, so the outcome will depend on the result of an evolutionary arms race.

But, using Dembski's self-referencing logic, believers in intelligent design have to accept that the 'complex specified information' that enables brain tumours to reprogram neutrophils and so supress the immune system, must have been provided by an intelligent designer to achieve exactly that result, because, so he wrongly argues, mutation and natural selection alone can't produce a strategy for survival.

The bad news for supporters of Dembski's divine malevolence is that the discovery by researchers at the Wistar Institute may have tipped the balance in the arms race between human medical science and the malevolent designer in favour of human medical science, in that it suggests a form of treatment for this type of brain cancer.

Malevolent Designer - How Creationism's Divine Malevolence Ensured Its Zika Virus Infects Developing Babies

Zika virus's non-structural protein NS1 (red) and mitochondria (green) travel through the tunneling nanotube (TNT, gray) from infected to uninfected placental cells.

Image: Mysorekar lab.

A representation of the surface of the Zika virus, with protruding envelope glycoproteins shown in red.

Kuhn and Rossmann research groups, Purdue University

Stealth virus: Zika virus builds tunnels to covertly infect cells of the placenta | BCM

I've written recently about the lengths creationism's divine malevolence must have gone to to ensure one of its nasty little parasitic pathogens, the zika virus, gets to infect as many of its potential victims as possible. Science has now revealed how it then ensures as many babies being carried by its pregnant victims as possible are infected, by sneaking past the maternal/foetal barrier in the placenta.

Zika, is, of course, the mosquito-borne virus that causes microcephaly and associated mental handicap in babies whose mothers were infected during pregnancy.

To ensure the success of this method of increasing the suffering in the world, the designer had a major problem of its own making to overcome - it had given the human foetus a placenta that included a barrier between its circulation and that of the mother. This barrier is normally sufficient to prevent viruses crossing over into the developing foetus, so clearly, if an many children with microcephaly as possible are born, the designer had to find a way to bypass this barrier.

It produced the ingenious method of creating microtubules (small tunnels) between the mother's cells and the foetus's cells in the placenta and simply passing through them!

Unusually for creationism's divine malevolence, which normally behaves like a mindless evolutionary process and reinvents a novel solution for the same problem encountered by a different species, this is the same sneaky method used by a few other viruses to pass from cell to cell in a sheet of tissue, without going outside and making themselves available for the immune system to detect and respond to.

Malevolent Designer News - How Cancer is Cleverly Designed to Trick Our Immune System

Mitochondrial transfer and metabolic reprogramming of the tumor microenvironment aid cancer immune evasion

Mitochondrial transfer and metabolic reprogramming of the tumor microenvironment aid cancer immune evasion.

How Cancer Cells Trick the Immune System by Altering Mitochondria - Okayama University

There is an ongoing arms race between medical science and cancer - and guess whose side creationism's intelligent designer appears to be on.

Yep, it's the same intelligent designer who designed cancers in the first place by creating an error-prone DNA replication mechanism that goes wrong, as does the error-correction mechanism it designed to try to rectify its faulty design with an added layer of complexity. And one of the results of it going wrong is cancer.

One of the more hopeful treatments for cancer was a tailor-made immunotherapy in which specific antibodies to the cancer cells were used to attack the cancer and treat it like a parasitic pathogen, by training the immune system to recognise the cancer and attack and destroy it.

But, true to form, creationism's divine malevolence has hit back by designing a response by cancer cells to attack by cells of the immune system.

We can be sure this is the work of creationism's intelligent designer because William A Dembski, the Discovery Institute's flunky and pseudoscientist in residence, tells us that any genetic sequence that produces a function must have been given 'specified information' in the form of the DNA that codes for that specific protein because, so he claims, specified information is too complex to have evolved.

Malevolent Design - How Sudan Virus is Cleverly Designed to Kill 50% of Its Victims

Cryo-EM structure of Sudan ebolavirus glycoprotein complexed with its human endosomal receptor NPC1

New Study Reveals How Sudan Virus Binds to Human Cells | Midwest Antiviral Drug Discovery (AViDD) Center

It's shaping up to be a thrilling month for devotees of creationism's divine malevolence as science finds out just how brilliantly its nasty little parasites are designed to make us sick and increase the suffering in the world, although quite why any normal person would worship a hate-filled sadistic psychopath is even more of a mystery than the mechanism by which it designs and creates organisms.

The latest is the details of how the Sudan virus (a variant of Ebola with a 50% 'success' rate in terms of deaths of its victims) has an improved method of binding to our cells to gain entry and start the killing process. Like Ebola, it binds to receptors on the cell surface, but because it has just 4 different amino acids in its coat proteins, it binds much more efficiently - a factor which probably contributes to its high kill rate.