Wednesday, 9 July 2025

Creationism Refuted - Tree Pollen Record - from 140,000 Years Before 'Creation Week'


Tree pollen reveals 150,000 years of monsoon history in Northern Australia – News

Droughts in Southeast Asia and increasingly devastating floods in Northern Australia are not random anomalies—they are predictable consequences of climate change, as revealed by a 150,000-year record of monsoon patterns preserved in tree pollen from sediment in Girraween Lagoon near Darwin. This record, meticulously analysed and correlated with evidence of past climate change and ocean currents, offers a stark warning about what lies ahead.

Not only does this research thoroughly dismantle the juvenile creationist fantasy that Earth is a mere 6,000 to 10,000 years old, it also flatly contradicts the myth of a global flood just a few thousand years ago—such a cataclysm would have obliterated the very sediment that preserved this climate history. Moreover, it challenges the simplistic notion that Earth was "finely tuned" for life, since the data show a planet subject to instability and extreme hardship, at times rendering regions locally uninhabitable due to global climatic shifts.

The study, conducted by researchers at James Cook University and Flinders University, demonstrates that shifts in Northern Australia's monsoon patterns coincide with Heinrich events—sudden surges of cold meltwater into the North Atlantic that weaken the Gulf Stream. As the Gulf Stream drives much of Western Europe’s climate by transporting warm water across the Atlantic, its disruption would have profound consequences for Europe as well.

Can you tell me more about these Heinrich events, please. Heinrich events are dramatic climatic episodes that occurred during the last glacial period, named after marine geologist Hartmut Heinrich who first identified them in the 1980s. These events represent sudden and massive discharges of icebergs into the North Atlantic Ocean, originating primarily from the Laurentide Ice Sheet in North America.

Key Features of Heinrich Events:
  1. Ice-Rafted Debris (IRD):
    Heinrich events are identified by layers of sediment in North Atlantic marine cores that contain ice-rafted debris—fragments of rock and other materials carried by icebergs and dropped onto the seafloor as the ice melted.
  2. Abrupt Cooling:
    The influx of cold, fresh meltwater into the North Atlantic during a Heinrich event disrupted thermohaline circulation (the so-called Atlantic Meridional Overturning Circulation, or AMOC), particularly the Gulf Stream. This led to abrupt regional cooling, especially in Europe and North America.
  3. Duration and Frequency:
    These events occurred roughly every 7,000–10,000 years during the last glacial cycle (~70,000 to 10,000 years ago), though the exact timing and spacing varied. Each event may have lasted for several hundred to a few thousand years.
  4. Global Impact:
    Although triggered by North Atlantic dynamics, Heinrich events had global repercussions. Evidence shows climate responses as far afield as the Indian monsoon, tropical Africa, and South America, where rainfall patterns shifted dramatically. The study you linked to adds Northern Australia to that list, showing that these events influenced monsoons far from their origin.
  5. Mechanism:
    The most widely accepted model suggests that internal ice-sheet instability or subglacial processes triggered massive iceberg calving events. These icebergs melted in the North Atlantic, introducing vast amounts of fresh water and lowering ocean salinity. This in turn weakened or shut down deep-water formation, a key component of the global climate system.



Summary:

Heinrich events are natural examples of abrupt climate change—rapid and severe disruptions to the climate system caused by shifts in ocean circulation. They provide a powerful lesson for today: large-scale climatic systems can change quickly and globally in response to disturbances, especially involving the ocean’s role in heat and moisture distribution.
The team's findings are now published in Quaternary Science Reviews, and are also explained in lay terms in a Flinders University blog post.
Tree pollen reveals 150,000 years of monsoon history in Northern Australia
Northern Australia’s annual monsoon season brings relief to drought-stricken lands and revitalises crops and livestock for farmers. But a study of 150,000 years of climate records shows that the monsoon is likely to intensify, triggering a higher risk of flooding while worsening the impact of droughts in East Asia.
Led by Professor Michael Bird, researchers at James Cook University and Flinders University have assessed sediments at Girraween Lagoon near Darwin, revealing a continuous record of monsoon rainfall patterns dating back beyond the last interglacial period.

This research published in the scientific journal Quaternary Science Reviews offers insight into how climate change could alter monsoon patterns across East Asia and Australia.

This is the longest terrestrial record ever produced at the southern end of the Indo-Australian monsoon system, which delivers vital rainfall to millions across the Southern Hemisphere. The record also has implications for the Northern Hemisphere where tens of millions in Asia rely on monsoons for food and their livelihoods.

Our study shows how the two monsoon systems are interrelated over thousands of years and reveals what causes them to change. Our analyses shows that that rainfall in northern Australia is closely tied to sea level changes, which shift the location of the northern coastline by up to 320 km.

These shifts strongly alter local rainfall, with wetter periods occurring when the coastline is closer to the Australian landmass and the oppose effect is prolonged drought in East Asia.

Intriguingly, the research also uncovered what we consider bursts of intense monsoon activity — some lasting less than 10,000 years. These bursts align with Heinrich events — abrupt pulses of freshwater into the North Atlantic from rapidly melting ice linked to the weakening of the Gulf Stream in the Atlantic Ocean.

Professor Michael I. Bird, first author
College of Science and Engineering
James Cook University
Cairns, Queensland, Australia.

These findings carry a warning from scientists because the Gulf Stream is already weakening due to climate change, and the study suggests this could lead to increased rainfall in northern Australia while contributing to droughts in parts of East Asia.

This isn’t just ancient history. It is a window into the rainfall patterns that are emerging today. Our data suggest that the weather trends we’re witnessing like the drying in China and wetting in northern Australia could accelerate if the Gulf Stream continues to weaken, so we need to be ready for that scenario.

It’s not surprising. Decreasing rainfall in parts of the east Asian summer monsoon region has been identified in rainfall records since the 1960s, while increasing rainfall has been evident in north-western Australia since the last century, accelerating since the 1950s. Our new data suggest that further weakening of the Gulf Stream could reinforce these trends even more in the future, with consequences for both regions.

We need to put this impact into context because this region extends from China through Southeast Asia, the maritime continent, and western Indo-Pacific warm pool on the Equator, to Australia. The region is home to almost a billion people and five terrestrial Biodiversity Hotspots.

Professor Corey J. A. Bradshaw, co-author.
Global Ecology | Partuyarta Ngadluku Wardli Kuu
College of Science and Engineering
Flinders University,
Adelaide, South Australia, Australia.

Publication:
Highlights
  • 150 kyr n-alkane δ2H and pollen record of monsoon strength from northern Australia.
  • Coastline position strongly influenced local hydroclimate.
  • Monsoon intensity broadly anti-phased with East Asian Summer Monsoon.
  • Short (∼2–10 kyr) periods of dramatically increased monsoon intensity also occur.
  • Short periods of increased monsoon intensity align with Heinrich events.

Abstract
Nearly two thirds of the world's population depend on monsoon rainfall, with monsoon failure and extreme precipitation affecting societies for millennia. Monsoon hydroclimate is predicted to change as the climate warms, albeit with uncertain regional trajectories. Multiple glacial-interglacial terrestrial records of east Asian monsoon variability exist, but there are no terrestrial records of equivalent length from the coupled Indo-Australian monsoon at its southern limit — Australia. We present a continuous 150,000-year lacustrine record of monsoon dynamics from the core monsoon region of northern Australia based on the proportion of dryland tree pollen in the total dryland pollen spectra and the hydrogen isotope composition of long chain n-alkanes. We show that rainfall at the site depends strongly on sea level, which changes proximity of the coast to the site by 320 km over the last glacial-interglacial cycle. Long-term trends in rainfall are broadly anti-phased with the east Asian monsoon modulated by coastal proximity. The record also contains multiple, short intervals (∼2 to < 10,000 years) of large changes in tree cover (from 5 to 95 % tree pollen over 3000 years in one instance). Changes in tree cover are frequently but not always, accompanied by synchronous large changes in the other hydroclimate proxies. While these wetter periods cannot be easily ascribed to orbitally induced changes in insolation or coastal proximity, they are correlated with most Heinrich events. This relationship implies that strong asymmetry in inter-hemispheric monsoon rainfall might be one outcome of the current weakening in the strength of the Atlantic meridional overturning circulation, through a reduction in oceanic heat transfer from the Southern to the Northern Hemisphere.

1. Introduction
The dominant feature of climate across most of the tropics and subtropics is a seasonal reversal of the prevailing winds across the Equator, resulting in a wetter summer season and a drier winter in each hemisphere. At an annual scale, the ‘global monsoon’, approximated hydrologically by the zone of maximum rainfall associated with the intertropical convergence zone, oscillates between the Northern and Southern Hemispheres (An et al., 2015; Wang et al., 2017). This oscillation is driven by the annual cycle of maximum insolation between each hemisphere (Deininger et al., 2020), leading to anti-phased summer rainy seasons in each (Eroglu et al., 2016; Deininger et al., 2020). Agriculture and ecosystems across the tropics and subtropics depend on monsoon rainfall (An et al., 2015), and so growing populations and climate change increase vulnerability to any change in monsoon dynamics (Zhang et al., 2018; Martinez-Villalobos and Neelin, 2023). Indeed, drought associated with monsoon failure, as well as monsoon-related flooding, have driven major demographic changes in prehistory (e.g., Cook et al., 2010) and the recent past (Li et al., 2011; Qian et al., 2012; Wang et al., 2015.1).

The monsoon system that affects the largest land area and human population is the east Asian summer monsoon north of the Equator, coupled by cross-equatorial airflow to the Indo-Australian summer monsoon south of the Equator (Li and Li, 2014) (Fig. 1). This region extends from China through Southeast Asia, the maritime continent and western Indo-Pacific warm pool on the Equator, to Australia. The region is home to almost a billion people and five terrestrial biodiversity hotspots (Myers et al., 2000).
Fig. 1. Location of Girraween Lagoon in monsoonal north Australia. Also shown are the Sunda and Sahul continental shelves, with areas landward exposed at times of lower sea level, and the major pathways for water and heat transport between the Pacific and Indian Oceans via the Indonesian throughflow. Approximate boundaries of the true and ‘pseudo’ monsoon domains and directions of wet season airflow are in yellow (Suppiah, 1992). Insert shows the approximate dominant flows of the east Asian summer monsoon (EASM) and the Indo-Australian summer monsoon (IASM). Additional locations mentioned in the text are: 1 and 2: speleothem stable isotope records from KNI-51 and Ballgown Cave, respectively (Denniston et al., 2017.1); 3: marine core geochemical record of runoff and dust flux (Zhang et al., 2020.1; Pei et al., 2021; Sarim et al., 2023.1); 4: speleothem isotope record from Flores (Scroxton et al., 2022); 5 and 6: Woods and Gregory ‘megalakes’, respectively (Bowler et al., 1998, 2001; Fitzsimmons et al., 2012.1). Base image data: Google © 2023 Maxar Technologies. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
The Indo-Australian summer monsoon represents the dominant source of rainfall in northern Australia, although atmospheric teleconnections to other sources of global interannual climate variability, particularly El Niño-Southern Oscillation, contribute to rainfall variability (Sharmila and Hendon, 2020.2; Heidemann et al., 2023.2; Gallagher et al., 2024). The Indo-Australian summer monsoon in northern Australia also exhibits its own internal dynamics, due in approximately equal measure to local oceanic (sea surface temperature, evaporation, and wind) and terrestrial (land cover, soil moisture, evaporation, and wind) influences on rainfall (Yu and Notaro, 2020.3; Sekizawa et al., 2021.1; Heidemann et al., 2023.2; Sekizawa et al., 2023.3). While the east Asian summer monsoon is dominant due to the large, high-altitude Asian landmass, the internal dynamics of the Indo-Australian summer monsoon can also drive variability in east Asian winter monsoon rainfall in southern China, suggesting close linkages (Yu and Notaro, 2020.3; Sekizawa et al., 2021.1; Heidemann et al., 2023.2; Sekizawa et al., 2023.3).

Terrestrial speleothem oxygen isotope and pollen records (e.g., Ma et al., 2023.4; Chen et al., 2023.5) spanning one or more glacial-interglacial cycles have demonstrated periods of enhanced/(reduced) east Asian summer monsoon rainfall at times of higher/(lower) Northern Hemisphere insolation and distinct, weak monsoon intervals, some of which are coincident with Heinrich events (Cheng et al., 2009, 2016.1). However, equivalent long terrestrial records from the southern end of the Indo-Australian summer monsoon in northern Australia are conspicuously absent.

Proxy records of terrestrial runoff have been derived from marine records off north-western Australia and are correlated with east Asian summer monsoon records (Pei et al., 2021; Zhang et al., 2020.1; Sarim et al., 2023.1) (Fig. 1). However, those records are potentially confounded by the adjacent wide continental shelf that introduces an effect of sea-level change at orbital timescales on the delivery of runoff-derived sediment to the core locations. The locations are also likely affected by the large changes in land-sea distribution in the maritime continent that modify heat and mass transfer through the Indonesian throughflow upstream of the core sites (Lee et al., 2019). On land, a discontinuous speleothem time series of oxygen isotope has been generated covering the last 40 kyr (1 kyr = 1000 years) from northern Western Australia (Denniston et al., 2017.1), a location that is under the influence of the ‘pseudo’ monsoon (Suppiah, 1992; Gallagher et al., 2024) where airflow originates in the eastern Indian Ocean, rather than from equatorial regions to the north (Fig. 1).

In the arid interior of Australia, sediments from the former Woods and Gregory ‘megalakes’ (now small, ephemeral bodies of water) show that large perennial water bodies existed, dominantly during periods in Marine Isotope Stage (MIS) 3 around ∼ 50 ka ago, MIS 5 around 100 ka ago, as well as earlier (Bowler et al., 1998, 2001; Veth et al., 2009.1; Fitzsimmons et al., 2012.1). These megalakes were fed by monsoon rain falling into south-draining catchments, with drainage divides at least 300 km south of the modern north Australian coast (Fig. 1). Kati Thandi-Lake Eyre in central Southern Australia receives water from the core monsoon area (and other regions), but it also contains a record of megalake periods through MIS 5 to ∼ 116 ka ago and from 65 to 45 ka ago (Cohen et al., 2022.1).

The existence of interior megalakes, orders of magnitude larger than today's, implies past periods of higher monsoon rainfall penetrating these arid interior catchments (Wyrwoll and Valdes, 2003). Debate on the drivers of megalake-filling events has centred on the relative importance of sea level, sea surface temperatures, and Northern Hemisphere ‘push’ versus Southern Hemisphere ‘pull’ of monsoonal rain into the continental interior, as well as the role of vegetation feedbacks in augmenting moisture transfer inland (Wyrwoll and Valdes, 2003; Liu et al., 2004; Miller et al., 2005; Pitman and Hesse, 2007; Marshall and Lynch, 2008; Wyrwoll et al., 2007.1, 2012.2).

Here we present multiple, absolute-dated proxy records of sedimentological, hydroclimatic, and vegetation change over the last 150 kyr from a sediment core obtained from the core monsoon region of northern Australia, the Girraween Lagoon (Fig. 1). This record enables an assessment of the timing of variation in monsoon strength in the Indo-Australian summer monsoon domain that can be compared with records of east Asian summer monsoon strength and tropical hydroclimate. Together, this enables an assessment of the drivers of variability in the Indo-Australian summer monsoon.
The detailed sedimentary record from the Girraween Lagoon in Northern Australia, which includes evidence of Heinrich events spanning the last 150,000 years, presents a serious challenge to young Earth creationist claims. These events, triggered by massive iceberg discharges into the North Atlantic and linked to widespread climatic shifts—including monsoon disruptions in Australia—can be correlated across multiple geological archives worldwide. This implies a stable, continuous, and datable sequence of climatic change that extends far beyond the 6,000 to 10,000 years typically allowed by biblical literalists.

Creationist claims of a recent, global, catastrophic flood—often tied to the story of Noah—are also incompatible with this evidence. A flood of such scale would have scoured landscapes, disrupted or homogenised sedimentary layers, and left a very different geological signal. Instead, the sediments in Girraween Lagoon preserve a finely layered and uninterrupted record of environmental conditions, including pollen and isotopic data, spanning well over 100,000 years. Such a record simply could not survive the violent upheaval proposed by a recent global deluge.

Furthermore, the evidence of repeated, severe climatic disruptions also undermines the notion that Earth was perfectly created and "finely tuned" for life. The Heinrich events were episodes of extreme instability, during which entire regions became uninhabitable or suffered ecological collapse. This shows Earth’s climate system as dynamic and often harsh—not the static, life-friendly world one might expect from an intelligent designer. In short, the geological and climatological evidence paints a picture of an ancient, evolving Earth shaped by natural processes—one that flatly contradicts creationist dogma.

Creationism Refuted - How Evolving COVID-19 Is Making Creationism Sick

Simplified SARS-CoV-2 Evolutionary Tree
AI Generated image (ChatGPT4o)

News, in The Conversation that the latest variant of the Sars-CoV-2 virus that causes COVID-19, XFG, could soon become the dominant variant worldwide, prompted me to ask ChatGPT to construct a family tree for the known variants of the virus, to illustrate the basic principles of evolution that creationists continue to deny.

Construct a family tree of known SARS-CoV-2 variants and explain how this illustrates evolution in progress. Explanation: Evolution in Progress

This tree diagram represents a simplified phylogenetic tree of SARS-CoV-2, showing how the virus has evolved since it first emerged in Wuhan in late 2019.

Tuesday, 8 July 2025

Creationism Refuted - Evolution By LOSS of Genetic Information

Pycnogonum litoral, adult male feeding on a sea anemone.
C: Georg Brenneis

[Body]
Pycnogonum litorale, adult female feeding on a sea anemone.

C: Georg Brenneis
What the sea spider genome reveals about their bizarre anatomy

Creationists frequently argue that macroevolution without divine involvement is impossible because it supposedly requires the creation of new genetic information to code for novel structures. They assert that such new genetic information cannot arise through natural processes, claiming this would violate the Second Law of Thermodynamics. However, try getting a creationist to explain what the Second Law of Thermodynamics actually is, how it relates to genetic information, and why it supposedly forbids gene duplication, and it quickly becomes apparent that they haven’t the faintest idea what they’re talking about.

Of course, this entire argument hinges on a distorted definition of macroevolution, namely the claim that it must involve the appearance of entirely new structures not present in ancestral forms. Like so many creationist arguments, it is built on misinformation and the misrepresentation of fundamental biological concepts. Macroevolution refers to evolutionary changes above the species level, while evolution more broadly is defined as a change in allele frequencies in a population over time.

Another familiar plank in the creationist propaganda platform is the patently absurd claim that evolution cannot occur through a loss of genetic information, on the grounds that lost genetic material is always deleterious—if not fatal—and therefore cannot be passed on to subsequent generations. This claim, too, wilfully ignores well-established mechanisms in evolutionary biology.

So, a recent paper from an international team including researchers from the University of Vienna and the University of Wisconsin–Madison (USA) should present a problem for that narrative. The study shows that the bizarre body plan of marine arthropods known as sea spiders (Pycnogonida) is the result of a lost gene.

If creationists were intellectually honest, they might take this as a cue to question why creationist ‘scientists’ (to use the term loosely) are misleading them. More likely, however, they’ll claim that it’s the mainstream biologists who are doing the lying—despite the fact that the latter group provide empirical evidence to support their conclusions.

The research is detailed in an open-access paper in BMC Biology.

Creationism Refuted - Wooden Tools - From 290,000 Years Before 'Creation Week'

Reconstruction of wooden tools in use
AI generated image (ChatGPT4o)

A wooden tool is excavated from the site in China.
Photo: Bo Li.
2025 | Oldest wooden artefacts ever found in East Asia reveal plant-based diet of ancient humans - University of Wollongong – UOW

The childish notion of creationism took another battering today with the announcement that an international team of researchers, including University of Wollongong archaeologist Professor Bo Li, has unearthed a set of wooden tools in south-west China dating to approximately 300,000 years ago. That places them a full 290,000 years before creationists believe the Earth was formed, situating their manufacture and use within the 99.9975% of Earth’s history that occurred before the so-called ‘Creation Week’.

This date significantly predates the appearance of anatomically modern humans outside Africa. The exact identity of the archaic hominins who made and used these tools is uncertain — possibly early Denisovans, Homo heidelbergensis, or perhaps H. erectus. What we can say with confidence is that these hominins stand in stark contradiction to the Bronze Age origin myths recorded in the Bible, which many creationists insist are literal historical accounts.

The usual creationist response to such findings is to reject them outright as fabrications, the result of flawed methodology, or deliberate deception. However, the dating of these artefacts relies on a technique refined by Professor Li called electron spin resonance (ESR), which measures the time elapsed since the artefacts were buried. (See the side panel for further details.)

Sunday, 6 July 2025

Malevolent Designer News - How A Bacterium Is 'Intelligently Designed' To Spread Disease

Blacklegged tick, Ixodes scapularis

Bacteria hijack tick cell defenses to spread disease | WSU Insider

Here we have yet another example demonstrating that, if we apply Discovery Institute fellow William A. Dembski's criteria for proving intelligent design — namely the presence of complex specified genetic information — then we must conclude that creationism's supposed intelligent designer is, in fact, a malevolent force devising ever more sophisticated ways to inflict suffering on the world.

Once again, honest creationists are left with a stark dilemma: either complex specified information is indeed evidence of design, in which case the designer is malevolent, or it is not, in which case a central tenet of Intelligent Design creationism collapses. The dishonest ones, of course, will simply dismiss the evidence, likely misrepresent the science, and continue to bear false witness against scientists. In neither case should we expect creationists to admit that the theory of evolution fully accounts for the appearance of "malevolent" design, arising naturally without conscious intent or divine interference.

It’s a curious paradox that people who claim to worship the God of the Bible as an omnibenevolent, anthropophilic being are so often willing to see that deity cast in the role of a malevolent agent—so long as they can reject the theory of evolution. This strongly suggests that their opposition to evolution is not primarily theological, but political.

The latest example comes from the tick-borne pathogen Anaplasma, which causes anaplasmosis and contributes to Lyme disease. This bacterium hijacks the cellular machinery of ticks to ensure its own survival and transmission to new hosts, including humans. Although Dembski has famously avoided providing a rigorous, testable definition of "complex specified genetic information," any such definition would surely encompass genetic adaptations that promote survival and reproduction.

This discovery was made by researchers at the College of Veterinary Medicine, Washington State University (WSU). Their findings have just been published in Proceedings of the National Academy of Sciences (PNAS) and are explained in lay terms in WSU Insider, the university's online news outlet.

What information do you have on Anaplasma and the tick that transmits it? Anaplasma is a genus of bacteria that includes several species capable of causing disease in humans and animals. The most medically relevant species is Anaplasma phagocytophilum, which causes anaplasmosis—a tick-borne disease that affects both humans and various mammals.
  1. Overview of Anaplasma
    • Anaplasma are obligate intracellular bacteria in the family Anaplasmataceae.
    • They primarily infect white blood cells (especially neutrophils in the case of A. phagocytophilum).
    • Disease is often seasonal, peaking during the months of high tick activity (late spring to early autumn in temperate zones).

  2. Disease in Humans
    • Caused mainly by Anaplasma phagocytophilum.
    • Known as Human Granulocytic Anaplasmosis (HGA).
    • Symptoms include:
      • Fever, chills, headache
      • Muscle aches
      • Malaise
      • Occasionally gastrointestinal symptoms (nausea, vomiting)
      • In severe cases: respiratory failure, organ failure, neurological symptoms
    • Incubation period: ~5–14 days after a tick bite.
    • Treatment: Responds well to doxycycline, especially if started early.
    • If untreated, it can lead to complications, especially in the elderly or immunocompromised.

  3. Tick Vectors
    • The primary vector in the United States is the blacklegged tick (Ixodes scapularis), also called the deer tick.
    • In Europe, the main vector is the castor bean tick (Ixodes ricinus).
    • These are the same ticks that transmit Lyme disease (Borrelia burgdorferi) and Babesia (babesiosis), leading to frequent co-infections.

  4. Hosts and Reservoirs
    • Main animal reservoirs include:
      • White-tailed deer
      • Rodents
      • Small mammals
    • Ticks acquire the bacteria when feeding on an infected host and then transmit it during subsequent feedings.

  5. Biological Strategy of the Pathogen

    Recent research (such as the 2025 WSU referenced) shows that Anaplasmacan:
    • Hijack the tick's cellular defence mechanisms, particularly its oxidative stress response, allowing the bacteria to survive within the tick's gut.
    • Manipulate the cell death pathways of tick cells, suppressing apoptosis (programmed cell death) to extend the viability of the cells it infects.
    • Modify gene expression in the tick to enhance its own survival and transmission potential.

    These mechanisms qualify as highly sophisticated biological strategies—precisely the sort of adaptations that Intelligent Design proponents would struggle to explain without appealing to either special pleading or malevolent intent.

  6. Ecological and Public Health Impact
    • Geographic spread is increasing, partly due to climate change, which expands the habitat range of ticks.
    • Public health monitoring is challenged by co-infections and misdiagnosis (HGA is often confused with Lyme disease or viral infections).
    • Preventative strategies include tick checks, repellents, and public awareness campaigns.
Bacteria hijack tick cell defenses to spread disease
Washington State University researchers have discovered how the bacteria that cause anaplasmosis and Lyme disease hijack cellular processes in ticks to ensure their survival and spread to new hosts, including humans.
Based in the College of Veterinary Medicine, the team found that the bacteria can manipulate a protein known as ATF6, which helps cells detect and respond to infection, to support its own growth and survival inside the tick. The findings, published in the journal Proceedings of the National Academy of Sciences, could serve as a launching point for developing methods to eliminate the bacteria in ticks before they are transmitted to humans and other animals.

Most research has looked at how these bacteria interact with humans and animals and not how they survive and spread in ticks. What we have found could open the door to targeting these pathogens in ticks, before they are ever a threat to people.

Kaylee A. Vosbigian, lead author
Department of Veterinary Microbiology and Pathology
College of Veterinary Sciences
Washington State University, Pullman, WA, USA.

Vosbigian and her advisor, Dana Shaw, the corresponding author of the study and an associate professor in the Department of Veterinary Microbiology and Pathology, focused their research on Ixodes scapularis, also known as the black-legged tick, which is responsible for spreading both Anaplasma phagocytophilum and Borrelia burgdorferi, the causative agents of anaplasmosis and Lyme disease. Both diseases are becoming increasingly common and can cause serious illness in humans and animals.

The team discovered that when ATF6 is activated in tick cells, it triggers the production of stomatin, a protein that helps move cholesterol through cells as part of a normal cellular processes. The bacteria exploit this process against their tick hosts, using the cholesterol — which they need to grow and build their own cell membranes but cannot produce themselves — to support their own survival and success.

Stomatin plays a variety of roles in the cell, but one of its key functions is helping shuttle cholesterol to different areas. The bacteria take advantage of this, essentially stealing the cholesterol they need to survive.

Kaylee A. Vosbigian

When the researchers blocked the production of stomatin, restricting the availability of cholesterol, bacterial growth is significantly reduced. The researchers believe this shows targeting the ATF6-stomatin pathway could lead to new methods for interrupting the disease cycle in ticks before transmission occurs.

As part of the study, Vosbigian also developed a new research tool called ArthroQuest, a free, web-based platform hosted by WSU that allows scientists to search the genomes of ticks, mosquitoes, lice, sand flies, mites, fleas and other arthropod vectors for transcription factor binding sites — genetic switches like ATF6 that control gene activity.

There aren’t many tools out there for studying gene regulation in arthropods. Most are built for humans or model species like fruit flies, which are genetically very different from ticks.

Kaylee A. Vosbigian

Using ArthroQuest, the team found that ATF6-regulated control of stomatin appears to be prevalent in blood-feeding arthropods. Since the hijacking of cholesterol and other lipids is common among arthropod-borne pathogens, the researchers suspect many may also exploit ATF6.

We know many other vector-borne pathogens, like Borrelia burgdorferi and the malaria-causing parasite Plasmodium, rely on cholesterol and other lipids from their hosts. So, the fact that this ATF6-stomatin pathway exists in other arthropods could be relevant to a wide range of disease systems.

Assistant Professor Dana K. Shaw, corresponding author.
Department of Veterinary Microbiology and Pathology
College of Veterinary Sciences
Washington State University, Pullman, WA, USA.


Publication:
Significance
Infection dynamics for tick-borne pathogens like Anaplasma have primarily been studied in mammals. Comparatively less is known about tick–pathogen interactions. We found that Anaplasma activates the stress response receptor, ATF6, in ticks. Activated ATF6 functions as a transcriptional regulator. Using a custom script in R, we identified stomatin as an ATF6-regulated target that supports Anaplasma by modulating cholesterol trafficking. Our custom tool “ArthroQuest” revealed that the ATF6-regulated nature of stomatin is unique to arthropods. Given that lipid hijacking is common among arthropod-borne microbes, ATF6-mediated induction of stomatin may be exploited in many vector–pathogen relationships. In addition, our findings predict that there are many ATF6-regulated genes unique to ticks, highlighting that there is still much to be uncovered.

Abstract
How tick-borne pathogens interact with their hosts has been primarily studied in vertebrates where disease is observed. Comparatively less is known about pathogen interactions within the tick. Here, we report that Ixodes scapularis ticks infected with either Anaplasma phagocytophilum (causative agent of anaplasmosis) or Borrelia burgdorferi (causative agent of Lyme disease) show activation of the ATF6 branch of the unfolded protein response (UPR). Disabling ATF6 functionally restricts pathogen survival in ticks. When stimulated, ATF6 functions as a transcription factor, but is the least understood out of the three UPR pathways. To interrogate the Ixodes ATF6 transcriptional network, we developed a custom R script to query tick promoter sequences. This revealed stomatin as a potential gene target, which has roles in lipid homeostasis and vesical transport. Ixodes stomatin was experimentally validated as a bona fide ATF6-regulated gene through luciferase reporter assays, pharmacological activators, RNA interference transcriptional repression, and immunofluorescence microscopy. Silencing stomatin decreased A. phagocytophilum colonization in Ixodes and disrupted cholesterol dynamics in tick cells. Furthermore, blocking stomatin restricted cholesterol availability to the bacterium, thereby inhibiting growth and survival. Taken together, we have identified the Ixodes ATF6 pathway as a contributor to vector competence through Stomatin-regulated cholesterol homeostasis. Moreover, our custom, web-based transcription factor binding site search tool “ArthroQuest” revealed that the ATF6-regulated nature of stomatin is unique to blood-feeding arthropods. Collectively, these findings highlight the importance of studying fundamental processes in nonmodel organisms.

The North American deer tick, Ixodes scapularis, can transmit up to seven different pathogens that impact human and animal health including Anaplasma phagocytophilum (causative agent of anaplasmosis) and Borrelia burgdorferi (causative agent of Lyme disease) (1). The continuous rise in reported cases of tick-borne disease (210) underscores the need for novel intervention strategies. Although the intricacies of mammalian host–pathogen interactions have been well studied, comparatively little is known about tick–pathogen interactions.

Recently we have shown that A. phagocytophilum and B. burgdorferi activate the unfolded protein response (UPR) in ticks, which influences microbial colonization and persistence in the arthropod (11, 12). The UPR is a cellular response network that is initiated by three endoplasmic reticulum (ER) transmembrane receptors IRE1α, PERK, and ATF6. Each branch of the UPR initiates a signaling cascade and coordinates gene expression networks by activating specific transcription factors. We have shown that the IRE1α-TRAF2 pathway leads to microbe-restricting immune responses in arthropods by activating the NF-κB-like molecule, Relish (11). We have also demonstrated that stimulating PERK activates the antioxidant transcription factor, Nrf2, which facilitates pathogen persistence in ticks (12). Out of the three UPR receptors, ATF6 is the least understood (13). When activated, site-1 and site-2 proteases cleave the cytosolic portion of ATF6, which allows it to translocate to the nucleus and act as a transcriptional regulator (nATF6) (14). The role of ATF6 has never been explored in arthropod vectors.

Here, we demonstrate that Ixodes ATF6 is activated by tick-borne pathogens and supports A. phagocytophilum colonization in ticks. To determine how ATF6 impacts vector competence, we used protein modeling and a custom transcription factor binding site query to probe the ATF6 regulatory network in I. scapularis. Gene ontology (GO) and Reactome analyses identified Stomatin, a lipid homeostasis and vesical transport protein, as a potential gene regulated by ATF6 in ticks. Using pharmacological manipulations, RNA interference (RNAi), quantitative fluorescent assays, and immunofluorescence microscopy, we found that Stomatin supports pathogen colonization in ticks by facilitating cholesterol acquisition by the bacterium. These findings demonstrate that stomatin is induced during the arthropod-phase of the pathogen life cycle to enable survival and persistence in the vector.

Programs that predict transcription factor regulatory networks are generally restricted to model organisms, leaving out many arthropod vectors. We used our custom R script to develop a publicly available, web-based tool termed “ArthroQuest” that currently allows users to query 20 different arthropod vector genomes, in addition to Drosophila and humans. Queries with ArthroQuest revealed that the ATF6-regulated nature of stomatin appears to be unique to arthropods. Given that lipid hijacking and cholesterol incorporation is common in many arthropod-borne microbes (15), ATF6-mediated induction of stomatin may be a shared phenomenon among many vector–pathogen relationships that is exploited for the survival and persistence of transmissible pathogens.

This discovery poses a significant problem for proponents of Intelligent Design (ID) creationism because it challenges one of their core assertions: that complex specified information (CSI) within genetic material is a reliable indicator of an intelligent, purposeful designer. If we accept this premise, then we are compelled to ask why such intelligence would devote itself to crafting mechanisms that cause suffering, disease, and death—such as the ability of Anaplasma to hijack tick cell defences and ensure its own propagation at the expense of both ticks and mammalian hosts, including humans.

The usual ID response is to insist that their designer is benevolent — typically equated with the God of the Bible. But here, we are faced with a biological system so well-adapted to spreading infection that it must either be acknowledged as a product of evolutionary processes or attributed to a designer with malevolent intent. This is not a fringe example; it is one of many cases where nature reveals a level of intricate adaptation that ID advocates would normally cite as evidence for design, were it not so profoundly disturbing.

What this ultimately reveals is the theological inconsistency at the heart of ID creationism. The refusal to acknowledge the explanatory power of evolution, even when confronted with examples like Anaplasma, indicates that ID is not a scientific theory but a religious or ideological stance. The selective application of their own criteria — applauding "design" in butterflies but ignoring it in parasites — exposes the intellectual dishonesty behind the movement. Evolution, by contrast, provides a consistent and naturalistic framework that explains both the beautiful and the brutal features of the living world — without invoking a morally compromised designer.




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The Malevolent Designer: Why Nature's God is Not Good
This book presents the reader with multiple examples of why, even if we accept Creationism's putative intelligent designer, any such entity can only be regarded as malevolent, designing ever-more ingenious ways to make life difficult for living things, including humans, for no other reason than the sheer pleasure of doing so. This putative creator has also given other creatures much better things like immune systems, eyesight and ability to regenerate limbs that it could have given to all its creation, including humans, but chose not to. This book will leave creationists with the dilemma of explaining why evolution by natural selection is the only plausible explanation for so many nasty little parasites that doesn't leave their creator looking like an ingenious, sadistic, misanthropic, malevolence finding ever more ways to increase pain and suffering in the world, and not the omnibenevolent, maximally good god that Creationists of all Abrahamic religions believe created everything. As with a previous book by this author, "The Unintelligent Designer: Refuting the Intelligent Design Hoax", this book comprehensively refutes any notion of intelligent design by anything resembling a loving, intelligent and maximally good god. Such evil could not exist in a universe created by such a god. Evil exists, therefore a maximally good, all-knowing, all-loving god does not.

Illustrated by Catherine Webber-Hounslow.



The Unintelligent Designer: Refuting The Intelligent Design Hoax
ID is not a problem for science; rather science is a problem for ID. This book shows why. It exposes the fallacy of Intelligent Design by showing that, when examined in detail, biological systems are anything but intelligently designed. They show no signs of a plan and are quite ludicrously complex for whatever can be described as a purpose. The Intelligent Design movement relies on almost total ignorance of biological science and seemingly limitless credulity in its target marks. Its only real appeal appears to be to those who find science too difficult or too much trouble to learn yet want their opinions to be regarded as at least as important as those of scientists and experts in their fields.


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Friday, 4 July 2025

Refuting Creationism - The Mass Extinction 252 Million Years Before 'Creation Week'

Dr Zhen Xu on fieldwork in China.
Image credit: Zhen Xu

Pre-extinction tropical rainforest seed fern, Gigantopteris, (giant leaves)

Dr Zhen Xu.
New fossils reveal climate tipping point in most famous mass extinction | University of Leeds

Creationists claim that Earth is only a few thousand years old and that it was created perfectly and finely tuned for life—brought into existence without ancestors, from nothing, by means of supernatural command. Their evidence for this extraordinary claim rests on the beliefs of Bronze Age pastoralists who imagined Earth as small, flat, and covered by a solid dome. These ancient myths were eventually written down, bound up in a book later declared by people with a vested interest, to be divinely inspired and historically accurate.

Science, by contrast, presents a very different picture. Far from being a perfect and finely tuned haven for life, Earth is a dynamic and often hostile planet. Life persists here not because conditions are universally benign, but because a small number of organisms have evolved to thrive within narrow environmental niches. Throughout Earth’s long history, global conditions have periodically tipped into extremes so severe that they triggered mass extinction events. Unlike creationist claims, these conclusions are supported by tangible, testable evidence.

One such event—known as the Great Dying—occurred around 252 million years ago, relatively recent in the planet’s \~4.5 billion-year history. This catastrophe, the most severe extinction event known, was likely triggered by intense volcanic activity that caused a rapid and sustained rise in global temperatures. The resulting climate shift led to the collapse of tropical forests, which in turn reduced the planet’s capacity to absorb atmospheric carbon, driving further warming. This cascade of ecological breakdown led to the loss of most marine species and widespread collapse of terrestrial ecosystems.

The outcome was a planetary heatwave that lasted for approximately five million years.

New evidence for the role of rainforest collapse in both the onset and the recovery from the Great Dying has been presented by an international team of scientists, led by researchers from the University of Leeds and the China University of Geosciences in Wuhan. Their findings are detailed in a recent paper published in Nature Communications and summarised in a news release from the University of Leeds.

Thursday, 3 July 2025

Malevolent Design - How Having a Bigger Brain Made Humans More Vulnerable To Cancer Than Our Chimpanzee Cousins


A Single Genetic Mutation May Have Made Humans More Vulnerable to Cancer Than Chimpanzees | Newswise

According to creationists, humans are the designer’s special creation, and the Universe, Earth, and all life upon it were created solely for our benefit.

If that were the case, one might reasonably expect human design to be uniquely perfect—free from disease and physical defects. Yet, paradoxically, we are more prone to cancer than our closest evolutionary relatives, the other great apes. Recent research from the UC Davis Comprehensive Cancer Center suggests that this heightened cancer susceptibility may be linked to the very mutation that enabled us to develop our comparatively large brains.

It’s almost as though the 'designer' either deliberately endowed humans with a cancer-promoting mutation or failed to anticipate the consequences of the so-called "complex specified genetic information" (© William A. Dembski / Discovery Institute) introduced to facilitate brain growth—and then neglected to revise the design when the flaw became evident. But, of course, being omniscient, we have to assume, if we accept creationists dogma for the sake of argument, it knew full well what the consequences of its design would be and designed them with that consequence in mind.

The theory of evolution, of course, precisely predicts these kinds of suboptimal trade-offs and their consequences. As an undirected, uncaring process, evolution is concerned solely with reproductive success—not with long-term health, perfection, or ideal design.

Creationism Refuted - Ancient DNA From Before Noah's Flood Shows Genetic Diversity

Final facial depiction of the Nuwayrat individual.

Reconstruction of the potter's face
Geographic location of the Nuwayrat cemetery (red dot), and the previously sequenced Third Intermediate period individuals from Abusir-el Meleq (purple diamond).

Credit: Adeline Morez Jacobs.
Researchers sequence first genome from ancient Egypt | Crick

According to the biblical narrative, the entire human population of Earth was reduced to just eight related individuals around 4,000 years ago, following a global, genocidal flood — a flood which, curiously, left no trace.

Now, as is almost invariably the case, new scientific evidence is entirely inconsistent with that narrative. The genetic analysis of an individual who lived and died in Egypt between 4,500 and 4,800 years ago shows that he was approximately 80% North African, with the remaining 20% of his DNA tracing to the vicinity of Mesopotamia.

Historical evidence also shows that, long before the supposed global flood, agriculture-based civilisations had been established in both Egypt and Mesopotamia. These societies had already formed trading networks and cultural connections, and left behind artefacts — including stone structures and buried remains — which would have been completely obliterated by the kind of flood described in the Bible.
Pottery vessel in which the Nuwayrat individual was discovered.

Image: Garstang Museum of Archaeology, University of Liverpool.
More telling still is that, by 4,500 years ago, the human population — which, according to the biblical account, had only recently descended from a single family via incestuous inbreeding — had already diversified to the point that measurable genetic differences existed between the Egyptian and Mesopotamian populations. This diversity is what made such DNA analysis possible in the first place.

The analysis of this individual’s genome — the oldest Egyptian DNA recovered to date — was carried out by researchers from the Francis Crick Institute and Liverpool John Moores University (LJMU), UK. They have just published their findings, open access, in Nature.

Wednesday, 2 July 2025

Malevolent Designer - How A Common Virus Sneaks Past Our Immune System And Causes Birth Defects


Scientists Uncover How a Common Herpes Virus Outsmarts the Immune System | School of Medicine | University of Pittsburgh.

Intelligent (sic) Design creationists have painted themselves into a corner.

Two of their most prominent arguments—irreducible complexity (Michael J. Behe) and complex specified information (William A. Dembski)—are intended to demonstrate the involvement of an intelligent designer in the natural world. But when these same criteria are applied to harmful parasitic organisms, such as the common herpesvirus (cytomegalovirus), which is the leading infectious cause of birth defects in the United States, the implication is that this virus too is the product of intentional design by the same creator that ID proponents insist is responsible for all life.

Within the framework of Intelligent Design creationism, the conclusion is inescapable: their designer deity—typically equated with the omniscient, omnibenevolent god of the Christian Bible—knowingly and deliberately created a pathogen that causes immense suffering. If ID logic is followed consistently, their deity is not a benevolent creator but a malevolent force that engineers disease and deformity with full foreknowledge of the consequences.

The only escape from this theological and philosophical bind is for ID creationists to refute their own criteria—to claim that irreducible complexity and complex specified information are compelling proof of design when found in beneficial biological systems, but somehow irrelevant or invalid when found in destructive pathogens. In doing so, they are forced to hold two mutually exclusive beliefs simultaneously.

In reality, these hallmarks of design touted by ID advocates are common outcomes of natural evolutionary processes — especially arms races between host defences and parasitic invaders. These processes are inherently unguided and wasteful, which in itself refutes the idea of intelligent planning.

Another striking example of this evolutionary struggle has just been published in Nature Microbiology by researchers from the University of Pittsburgh School of Medicine and the La Jolla Institute for Immunology. Their study sheds light on how the herpesvirus has evolved sophisticated strategies to evade the immune system — a feature that ID logic would classify as evidence of "design."

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