A study recently published in the Journal of Human Evolution reports the discovery of a mixture of archaic and modern traits in the dentition of 300,000-year-old hominin fossils unearthed at the Hualongdong site in Anhui Province, China.
These fossils predate the migration of anatomically modern humans (Homo sapiens) out of Africa by around 250,000 years. They indicate that hominin populations in East Asia were already diversifying and possibly interbreeding with archaic humans, such as Homo erectus, to form lineages distinct from both Neanderthals and Denisovans.
The research, led by Professor Wu Xiujie, director of the Hualongdong excavations, is the result of a longstanding collaboration between scientists from the Dental Anthropology Group at CENIEH — María Martinón-Torres, Director of CENIEH and corresponding author of the paper, and José María Bermúdez de Castro, researcher ad honorem at CENIEH — and the Institute of Vertebrate Paleontology and Paleoanthropology (IVPP) in Beijing.
The findings reveal a rich and complex picture of human evolution in East Asia, wholly at odds with the simplistic biblical narrative still clung to by creationists. That account, written by ancient people with no knowledge of the broader world, reflects a worldview in which Earth was small, flat, covered by a dome, and located at the centre of the universe.
A group of Issa Valley chimpanzees navigate an open woodland crown to forage on new leaves.
Image by Rhianna C. Drummond-Clarke/Greater Mahale Ecosystem Research and Conservation (GMERC)
A new study published in Frontiers in Ecology and Evolution delivers yet more evidence for the Theory of Evolution and decisively contradicts Bible-literalist creationism. By closely studying wild chimpanzees in Tanzania’s Issa Valley—an environment that mirrors the mixed woodland–savannah habitats of our early ancestors—researchers found that these apes still spend most of their time in trees and conduct over 85 % of their bipedal movements arboreally. This finding strongly supports the evolutionary view that human bipedalism did not emerge from a sudden exodus from trees but evolved gradually while our ancestors still relied heavily on arboreal habitats.
What is particularly striking is the complete absence of any doubt among the scientists that evolution, driven by natural selection, is the correct framework for interpreting these observations. At no point do they resort to supernatural explanations or even hint that evolution might be insufficient to explain the data. On the contrary, their conclusions seamlessly integrate with the existing evolutionary narrative, demonstrating how behaviours seen in modern chimpanzees provide a living window into the adaptations of our shared ancestors. This directly undermines the creationist claim that mainstream biologists are “abandoning” evolution in favour of unproven religious explanations—a claim that has no basis in reality.
Creationist dogma insists on static, unchanging “kinds” and appeals to unverifiable supernatural causes. Yet, studies like this show that every aspect of our evolutionary past—anatomical, genetic, and behavioural—can be explained through natural processes, without the need for divine intervention. The evidence for a shared ancestry between humans and other primates grows with every new study, while creationism remains stuck with no predictive power and no scientific methodology.
In short, this research reinforces the power and universality of the Theory of Evolution. The scientists involved didn’t set out to “disprove creationism”; they simply applied rigorous observation and analysis, and the results—once again—fell squarely on the side of evolution. Far from being abandoned, the ToE continues to thrive as the backbone of modern biology, while creationism, with its untestable supernatural entities, offers no explanation at all.
Excavation at the Neumark-Nord 2 in central Germany.
Photo: Professor Wil Roebroeks, Leiden University
125,000-year-old Neanderthal ‘fat factory’ discovered in Germany - Leiden University
More evidence has emerged that Neanderthals were far from the slow-witted, lumbering brutes of popular myth. In fact, they were highly organised, culturally sophisticated, and capable of processing food on what can only be described as an industrial scale.
This latest insight comes from a team of archaeologists led by researchers from MONREPOS (Leibniz Centre for Archaeology, Germany) and Leiden University (The Netherlands), in collaboration with the State Office for Heritage Management and Archaeology Saxony-Anhalt (Germany). Their findings were recently published in Science Advances.
At a site known as Neumark-Nord 2 in central Germany, dating back 125,000 years, the researchers have discovered compelling evidence of a bone-processing ‘factory’. Here, Neanderthals systematically broke up the massive bones of straight-tusked elephants and other large mammals—including deer, horses, and aurochs—to extract fat from the marrow by steeping the fragments in hot water. The straight-tusked elephant, which could weigh up to 13 tonnes, would have yielded enough meat to feed 2,000 adult humans their daily caloric needs.
This site predates the arrival of modern humans in Europe by tens of thousands of years, placing it firmly within the Neanderthal era. At the time, Europe was enjoying an interglacial period with a climate comparable to today's.
From an early age, the human brain interprets patters and sees faces everywhere. Draw two large black discs on a white sheet of paper and show it to a human baby of just a few weeks old and you will probably make the baby smile, just as they smile when they look at your face. Their brain has perceived the dots as the eyes of a face. This is the phenomenon of human perception known as pareidolia.
Some religious people, in an effort to justify holding irrational beliefs, often attribute these appearances of 'Jesus' or 'Mary', as miracles with some deep religious significance. For example, this anti-Atheist Gotcha, which appeared on Quora a couple of years ago:
Atheists, if there is no God, then why does Jesus' face sometimes appear on toast?
Imagine walking through the woods and briefly believing you're seeing a face in a knot of moss—only to realise seconds later that it’s just a tree. That flicker of recognition is your brain’s face-detection machinery springing into action. In a recent experiment at the University of Surrey, researchers used gaze-cueing techniques to show that when people perceive a face-like arrangement in inanimate objects, their attention is captured even more powerfully than by the averted gaze of a real face. These face-like patterns don’t need eyes, a nose, or even realistic features—just the right suggestion of symmetry and placement is enough for the brain to “see” a face where none exists.
This phenomenon, known as face pareidolia, is a by-product of evolution, not evidence of design. From an evolutionary standpoint, it's safer to wrongly detect a face in a shadow than to miss a predator or an ally. But while this trait once had clear survival value, it now fuels more curious beliefs. Religious individuals, for instance, often interpret pareidolic faces—especially when perceived in burnt toast, water stains, or tree bark—as miraculous signs from divine figures like Jesus or the Virgin Mary. What neuroscience tells us is that these “visions” are false positives produced by a brain primed to find patterns and assign meaning, even when none exists. Evolution has given us a perceptual system that’s fast, but not always accurate—and our cultural context then fills in the rest.
How the human brain interprets so many things as faces is the subject of a recent open access paper in i-Perception by researchers led by Dr Di Fu of the University of Surrey, with colleagues from the Institute of Psychology, Chinese Academy of Sciences.
A spiral galaxy with a disc made up of several swirling arms. Patchy blue clouds of gas are speckled over the disc, where stars are forming and lighting up the gas around them. The core of the galaxy is large and shines brightly gold, while the spiral arms are a paler and faint reddish colour. Neighbouring galaxies - from small, elongated spots to larger swirling spirals - can be seen across the black background.
Take a grain of rice and hold it between your thumb and forefinger at arm’s length while looking up at the night sky. The patch of sky hidden behind that tiny grain of rice probably contains thousands of galaxies—each with around half a trillion stars. Some of these stars are ancient, nearing the end of their tens-of-millions-of-years lifespans; others are just beginning to form from clouds of gas and debris left behind by older stars that exploded as supernovae.
What lies behind that grain of rice is a tiny fragment of a dynamic, evolving, ever-changing, and expanding universe. A universe of which our ancient prophets were completely unaware as they crafted imaginative descriptions of its origins—descriptions written just a few thousand years ago that portrayed it as a small, unchanging cosmos, with a flat Earth at the centre covered by a dome.
But let’s not be too hard on them. As they stood in their Canaanite pastures, the Earth must indeed have looked flat and small, and the sky would have seemed like the roof of a great tent, adorned with tiny lights and with the sun and moon suspended from it. To them, the Earth appeared fixed and immobile while the dome overhead turned slowly, or perhaps invisible spirits moved the lights across the heavens each night. They didn’t know where the sun went after sunset and imagined the moon might hide in a deep valley during the day.
In that long stretch of Earth’s history before it was supposedly "created," according to creationist mythology—a span covering 99.9975% of the planet’s existence—a remarkable geophysical event occurred. Around 41,000 years ago, during a time when modern humans, Neanderthals, and Denisovans coexisted in Eurasia, a major disturbance in Earth’s magnetic field likely influenced human behaviour and may have hastened the disappearance of the Neanderthals.
This event, known as the Laschamps Excursion, was not a typical magnetic pole reversal, which Earth undergoes roughly every 100,000 years. Instead, the planet's magnetic field entered a chaotic state, weakening dramatically to around 10% of its usual strength and breaking into multiple, unstable poles.
Earth’s magnetic field normally shields the surface from ionising radiation by deflecting much of it towards the poles. With that protective barrier severely weakened, the planet would have been exposed to much stronger levels of ultraviolet radiation. The usual deflection of charged particles also produces the auroras, which during this period would have appeared across much of the night sky, including at lower latitudes—perhaps even near the equator—due to the multiple and shifting magnetic poles.
Although the Laschamps Excursion lasted only a few years, the environmental changes it triggered may explain behavioural shifts visible in the archaeological record. This is discussed in an article in The Conversation by Raven Garvey, Associate Professor of Anthropology at the University of Michigan; Agnit Mukhopadhyay, Research Scholar at the University of Alberta and Research Affiliate at Michigan; and Sanja Panovska, a Research Scientist at the GFZ Helmholtz Centre for Geosciences. Together with their colleagues, they have published their findings—open access—in Science Advances.
Incidentally, the archaeological evidence discussed here should not exist at all if the biblical flood narrative were true. Such a flood would have obliterated or buried this material beneath a chaotic layer of silt, destroying the stratified layers of sediment by which these finds are reliably dated—dating that is wholly inconsistent with the timeline of human history as derived from biblical mythology. Moreover, the Laschamps Excursion undermines any creationist claim that the Earth was created and fine-tuned especially for human life. If something as fundamental as magnetic polarity—and the UV protection it affords—can fail naturally due to processes in Earth’s core, then the idea of a specially designed planet collapses under its own absurdity.
The article from The Conversation is reproduced below under a Creative Commons licence and has been reformatted for stylistic consistency.
Imaginative reconstruction of Novaculadon mirabilis. Likely this animal would have been a little larger than a mouse.
Picture credit: Hamzah Imran.
(L-R) Dr Roy Smith and University of Portsmouth student Ben Weston by the flint bed in Durlston Bay near Swanage, which is the layer of rock which the mammal fossil came out of.
When someone grows up being threatened with divine punishment for merely entertaining doubts about the literal truth of the Bible, it's hardly surprising that real-world evidence struggles to break through the psychological defences they've built to protect themselves. This phenomenon is what atheist author and philosopher, Professor Peter Boghossian refers to as doxastic closure — a mental state in which contrary ideas are shut out before they can even be considered.
Former young-Earth creationist and now science advocate and geologist Glenn Morton once described it as like having a “gatekeeper demon” perched on the edge of your consciousness—filtering out any facts or logical arguments that challenge creationist beliefs, while admitting only those misrepresentations of science that appear to support them.
In this mindset, inconvenient realities — such as the discovery of a 145-million-year-old fossil of an early mammal — are unlikely to dent the conviction that the Earth is only 6,000 to 10,000 years old, and that all animals were created in a single supernatural event. In this view, evolution is simply an illusion, no matter how well the evidence supports it.
Even so, for any creationist with the courage and intellectual honesty to read this far, the story of that inconvenient little fossil is well worth exploring. It was discovered by a palaeontology student from the University of Portsmouth, along the Dorset coast of England, and is the subject of a recent paper in Proceedings of the Geologists’ Association.
This find marks the first discovery of a multituberculate jaw at Swanage since Victorian times. Its distinct size and shape confirmed it as a completely new species.
According to creationist superstition, humans were specially created by a perfect, anthropophilic, omnibenevolent creator god. If that were true, it would be reasonable to expect humans to be perfectly designed—free from defects or anything likely to cause long-term suffering.
However, the facts do not support this view. For example, as humans age, they increasingly suffer from a condition known as inflammaging — low-grade, chronic inflammation that contributes to a range of health problems, including heart disease, strokes, diabetes, cancer, and osteoarthritis.
Properly understood, this should give creationists cause for concern. The same designer god apparently gave some other primates—most notably, certain species of lemur—the ability to avoid this consequence of ageing. In fact, these lemurs even show a reduced tendency toward inflammatory conditions as they grow older.
This raises a serious question for Intelligent Design creationists: if the same designer god was capable of creating such a mechanism for lemurs, why did it not see fit to bestow the same gift upon its supposed favourite creation—humans? Or are these inflammatory conditions intended to cause suffering and disease as we age?
The discovery that some lemurs appear to have been specially favoured by a creator god—if we accept the ID creationist premise for the sake of argument—was made by a team of researchers led by Elaine Elizabeth Gomez Guevara, a biological anthropologist in the Department of Evolutionary Anthropology at Duke University, Durham, USA. As a scientist and biologist, however, she attributes the differences between lemurs and humans to evolution — not to indifference or malevolence on the part of a designer god.
The Cat's Paw Nebula in all its glory, as revealed by the JWST on its third anniversary of science operations.
Image Credit: NASA, ESA, CSA, STScI
This is a zoomed-in portion of the JWST's Cat's Paw image. It shows a cavity surrounded by filaments and clumps of gas and dust. The cavity has been hollowed out by a hot young star which lights its surroundings up in blue.
To celebrate its third anniversary, astronomers used the NASA/ESA/CSA James Webb Space Telescope to scratch beyond the surface of the Cat’s Paw Nebula (NGC 6334), a massive, local star-forming region.
This is what they saw. Compare it to the description of the universe in the Bible - a small flat planet with a dome over it at the center, with the sun and moon attached to the dome and stars stuck to its underside, able to be shaken lose in earthquakes.
Here is what the late great Carl Sagan had to say about how religions view the universe:
Here we have yet another example demonstrating that, if we apply Discovery Institute fellow William A. Dembski's criteria for proving intelligent design — namely the presence of complex specified genetic information — then we must conclude that creationism's supposed intelligent designer is, in fact, a malevolent force devising ever more sophisticated ways to inflict suffering on the world.
Once again, honest creationists are left with a stark dilemma: either complex specified information is indeed evidence of design, in which case the designer is malevolent, or it is not, in which case a central tenet of Intelligent Design creationism collapses. The dishonest ones, of course, will simply dismiss the evidence, likely misrepresent the science, and continue to bear false witness against scientists. In neither case should we expect creationists to admit that the theory of evolution fully accounts for the appearance of "malevolent" design, arising naturally without conscious intent or divine interference.
It’s a curious paradox that people who claim to worship the God of the Bible as an omnibenevolent, anthropophilic being are so often willing to see that deity cast in the role of a malevolent agent—so long as they can reject the theory of evolution. This strongly suggests that their opposition to evolution is not primarily theological, but political.
The latest example comes from the tick-borne pathogen Anaplasma, which causes anaplasmosis and contributes to Lyme disease. This bacterium hijacks the cellular machinery of ticks to ensure its own survival and transmission to new hosts, including humans. Although Dembski has famously avoided providing a rigorous, testable definition of "complex specified genetic information," any such definition would surely encompass genetic adaptations that promote survival and reproduction.
What information do you have on Anaplasma and the tick that transmits it?
Anaplasma is a genus of bacteria that includes several species capable of causing disease in humans and animals. The most medically relevant species is Anaplasma phagocytophilum, which causes anaplasmosis—a tick-borne disease that affects both humans and various mammals.
Overview of Anaplasma
Anaplasma are obligate intracellular bacteria in the family Anaplasmataceae.
They primarily infect white blood cells (especially neutrophils in the case of A. phagocytophilum).
Disease is often seasonal, peaking during the months of high tick activity (late spring to early autumn in temperate zones).
In severe cases: respiratory failure, organ failure, neurological symptoms
Incubation period: ~5–14 days after a tick bite.
Treatment: Responds well to doxycycline, especially if started early.
If untreated, it can lead to complications, especially in the elderly or immunocompromised.
Tick Vectors
The primary vector in the United States is the blacklegged tick (Ixodes scapularis), also called the deer tick.
In Europe, the main vector is the castor bean tick (Ixodes ricinus).
These are the same ticks that transmit Lyme disease (Borrelia burgdorferi) and Babesia (babesiosis), leading to frequent co-infections.
Hosts and Reservoirs
Main animal reservoirs include:
White-tailed deer
Rodents
Small mammals
Ticks acquire the bacteria when feeding on an infected host and then transmit it during subsequent feedings.
Biological Strategy of the Pathogen
Recent research (such as the 2025 WSU referenced) shows that Anaplasmacan:
Hijack the tick's cellular defence mechanisms, particularly its oxidative stress response, allowing the bacteria to survive within the tick's gut.
Manipulate the cell death pathways of tick cells, suppressing apoptosis (programmed cell death) to extend the viability of the cells it infects.
Modify gene expression in the tick to enhance its own survival and transmission potential.
These mechanisms qualify as highly sophisticated biological strategies—precisely the sort of adaptations that Intelligent Design proponents would struggle to explain without appealing to either special pleading or malevolent intent.
Ecological and Public Health Impact
Geographic spread is increasing, partly due to climate change, which expands the habitat range of ticks.
Public health monitoring is challenged by co-infections and misdiagnosis (HGA is often confused with Lyme disease or viral infections).
Preventative strategies include tick checks, repellents, and public awareness campaigns.
Bacteria hijack tick cell defenses to spread diseaseWashington State University researchers have discovered how the bacteria that cause anaplasmosis and Lyme disease hijack cellular processes in ticks to ensure their survival and spread to new hosts, including humans.
Based in the College of Veterinary Medicine, the team found that the bacteria can manipulate a protein known as ATF6, which helps cells detect and respond to infection, to support its own growth and survival inside the tick. The findings, published in the journal Proceedings of the National Academy of Sciences, could serve as a launching point for developing methods to eliminate the bacteria in ticks before they are transmitted to humans and other animals.
Most research has looked at how these bacteria interact with humans and animals and not how they survive and spread in ticks. What we have found could open the door to targeting these pathogens in ticks, before they are ever a threat to people.
Kaylee A. Vosbigian, lead author
Department of Veterinary Microbiology and Pathology
College of Veterinary Sciences
Washington State University, Pullman, WA, USA.
Vosbigian and her advisor, Dana Shaw, the corresponding author of the study and an associate professor in the Department of Veterinary Microbiology and Pathology, focused their research on Ixodes scapularis, also known as the black-legged tick, which is responsible for spreading both Anaplasma phagocytophilum and Borrelia burgdorferi, the causative agents of anaplasmosis and Lyme disease. Both diseases are becoming increasingly common and can cause serious illness in humans and animals.
The team discovered that when ATF6 is activated in tick cells, it triggers the production of stomatin, a protein that helps move cholesterol through cells as part of a normal cellular processes. The bacteria exploit this process against their tick hosts, using the cholesterol — which they need to grow and build their own cell membranes but cannot produce themselves — to support their own survival and success.
Stomatin plays a variety of roles in the cell, but one of its key functions is helping shuttle cholesterol to different areas. The bacteria take advantage of this, essentially stealing the cholesterol they need to survive.
Kaylee A. Vosbigian
When the researchers blocked the production of stomatin, restricting the availability of cholesterol, bacterial growth is significantly reduced. The researchers believe this shows targeting the ATF6-stomatin pathway could lead to new methods for interrupting the disease cycle in ticks before transmission occurs.
As part of the study, Vosbigian also developed a new research tool called ArthroQuest, a free, web-based platform hosted by WSU that allows scientists to search the genomes of ticks, mosquitoes, lice, sand flies, mites, fleas and other arthropod vectors for transcription factor binding sites — genetic switches like ATF6 that control gene activity.
There aren’t many tools out there for studying gene regulation in arthropods. Most are built for humans or model species like fruit flies, which are genetically very different from ticks.
Kaylee A. Vosbigian
Using ArthroQuest, the team found that ATF6-regulated control of stomatin appears to be prevalent in blood-feeding arthropods. Since the hijacking of cholesterol and other lipids is common among arthropod-borne pathogens, the researchers suspect many may also exploit ATF6.
We know many other vector-borne pathogens, like Borrelia burgdorferi and the malaria-causing parasite Plasmodium, rely on cholesterol and other lipids from their hosts. So, the fact that this ATF6-stomatin pathway exists in other arthropods could be relevant to a wide range of disease systems.
Assistant Professor Dana K. Shaw, corresponding author.
Department of Veterinary Microbiology and Pathology
College of Veterinary Sciences
Washington State University, Pullman, WA, USA.
Significance
Infection dynamics for tick-borne pathogens like Anaplasma have primarily been studied in mammals. Comparatively less is known about tick–pathogen interactions. We found that Anaplasma activates the stress response receptor, ATF6, in ticks. Activated ATF6 functions as a transcriptional regulator. Using a custom script in R, we identified stomatin as an ATF6-regulated target that supports Anaplasma by modulating cholesterol trafficking. Our custom tool “ArthroQuest” revealed that the ATF6-regulated nature of stomatin is unique to arthropods. Given that lipid hijacking is common among arthropod-borne microbes, ATF6-mediated induction of stomatin may be exploited in many vector–pathogen relationships. In addition, our findings predict that there are many ATF6-regulated genes unique to ticks, highlighting that there is still much to be uncovered.
Abstract
How tick-borne pathogens interact with their hosts has been primarily studied in vertebrates where disease is observed. Comparatively less is known about pathogen interactions within the tick. Here, we report that Ixodes scapularis ticks infected with either Anaplasma phagocytophilum (causative agent of anaplasmosis) or Borrelia burgdorferi (causative agent of Lyme disease) show activation of the ATF6 branch of the unfolded protein response (UPR). Disabling ATF6 functionally restricts pathogen survival in ticks. When stimulated, ATF6 functions as a transcription factor, but is the least understood out of the three UPR pathways. To interrogate the Ixodes ATF6 transcriptional network, we developed a custom R script to query tick promoter sequences. This revealed stomatin as a potential gene target, which has roles in lipid homeostasis and vesical transport. Ixodes stomatin was experimentally validated as a bona fide ATF6-regulated gene through luciferase reporter assays, pharmacological activators, RNA interference transcriptional repression, and immunofluorescence microscopy. Silencing stomatin decreased A. phagocytophilum colonization in Ixodes and disrupted cholesterol dynamics in tick cells. Furthermore, blocking stomatin restricted cholesterol availability to the bacterium, thereby inhibiting growth and survival. Taken together, we have identified the Ixodes ATF6 pathway as a contributor to vector competence through Stomatin-regulated cholesterol homeostasis. Moreover, our custom, web-based transcription factor binding site search tool “ArthroQuest” revealed that the ATF6-regulated nature of stomatin is unique to blood-feeding arthropods. Collectively, these findings highlight the importance of studying fundamental processes in nonmodel organisms.
The North American deer tick, Ixodes scapularis, can transmit up to seven different pathogens that impact human and animal health including Anaplasma phagocytophilum (causative agent of anaplasmosis) and Borrelia burgdorferi (causative agent of Lyme disease) (1). The continuous rise in reported cases of tick-borne disease (2–10) underscores the need for novel intervention strategies. Although the intricacies of mammalian host–pathogen interactions have been well studied, comparatively little is known about tick–pathogen interactions.
Recently we have shown that A. phagocytophilum and B. burgdorferi activate the unfolded protein response (UPR) in ticks, which influences microbial colonization and persistence in the arthropod (11, 12). The UPR is a cellular response network that is initiated by three endoplasmic reticulum (ER) transmembrane receptors IRE1α, PERK, and ATF6. Each branch of the UPR initiates a signaling cascade and coordinates gene expression networks by activating specific transcription factors. We have shown that the IRE1α-TRAF2 pathway leads to microbe-restricting immune responses in arthropods by activating the NF-κB-like molecule, Relish (11). We have also demonstrated that stimulating PERK activates the antioxidant transcription factor, Nrf2, which facilitates pathogen persistence in ticks (12). Out of the three UPR receptors, ATF6 is the least understood (13). When activated, site-1 and site-2 proteases cleave the cytosolic portion of ATF6, which allows it to translocate to the nucleus and act as a transcriptional regulator (nATF6) (14). The role of ATF6 has never been explored in arthropod vectors.
Here, we demonstrate that Ixodes ATF6 is activated by tick-borne pathogens and supports A. phagocytophilum colonization in ticks. To determine how ATF6 impacts vector competence, we used protein modeling and a custom transcription factor binding site query to probe the ATF6 regulatory network in I. scapularis. Gene ontology (GO) and Reactome analyses identified Stomatin, a lipid homeostasis and vesical transport protein, as a potential gene regulated by ATF6 in ticks. Using pharmacological manipulations, RNA interference (RNAi), quantitative fluorescent assays, and immunofluorescence microscopy, we found that Stomatin supports pathogen colonization in ticks by facilitating cholesterol acquisition by the bacterium. These findings demonstrate that stomatin is induced during the arthropod-phase of the pathogen life cycle to enable survival and persistence in the vector.
Programs that predict transcription factor regulatory networks are generally restricted to model organisms, leaving out many arthropod vectors. We used our custom R script to develop a publicly available, web-based tool termed “ArthroQuest” that currently allows users to query 20 different arthropod vector genomes, in addition to Drosophila and humans. Queries with ArthroQuest revealed that the ATF6-regulated nature of stomatin appears to be unique to arthropods. Given that lipid hijacking and cholesterol incorporation is common in many arthropod-borne microbes (15), ATF6-mediated induction of stomatin may be a shared phenomenon among many vector–pathogen relationships that is exploited for the survival and persistence of transmissible pathogens.
This discovery poses a significant problem for proponents of Intelligent Design (ID) creationism because it challenges one of their core assertions: that complex specified information (CSI) within genetic material is a reliable indicator of an intelligent, purposeful designer. If we accept this premise, then we are compelled to ask why such intelligence would devote itself to crafting mechanisms that cause suffering, disease, and death—such as the ability of Anaplasma to hijack tick cell defences and ensure its own propagation at the expense of both ticks and mammalian hosts, including humans.
The usual ID response is to insist that their designer is benevolent — typically equated with the God of the Bible. But here, we are faced with a biological system so well-adapted to spreading infection that it must either be acknowledged as a product of evolutionary processes or attributed to a designer with malevolent intent. This is not a fringe example; it is one of many cases where nature reveals a level of intricate adaptation that ID advocates would normally cite as evidence for design, were it not so profoundly disturbing.
What this ultimately reveals is the theological inconsistency at the heart of ID creationism. The refusal to acknowledge the explanatory power of evolution, even when confronted with examples like Anaplasma, indicates that ID is not a scientific theory but a religious or ideological stance. The selective application of their own criteria — applauding "design" in butterflies but ignoring it in parasites — exposes the intellectual dishonesty behind the movement. Evolution, by contrast, provides a consistent and naturalistic framework that explains both the beautiful and the brutal features of the living world — without invoking a morally compromised designer.
Advertisement The Malevolent Designer: Why Nature's God is Not Good
This book presents the reader with multiple examples of why, even if we accept Creationism's putative intelligent designer, any such entity can only be regarded as malevolent, designing ever-more ingenious ways to make life difficult for living things, including humans, for no other reason than the sheer pleasure of doing so. This putative creator has also given other creatures much better things like immune systems, eyesight and ability to regenerate limbs that it could have given to all its creation, including humans, but chose not to. This book will leave creationists with the dilemma of explaining why evolution by natural selection is the only plausible explanation for so many nasty little parasites that doesn't leave their creator looking like an ingenious, sadistic, misanthropic, malevolence finding ever more ways to increase pain and suffering in the world, and not the omnibenevolent, maximally good god that Creationists of all Abrahamic religions believe created everything. As with a previous book by this author, "The Unintelligent Designer: Refuting the Intelligent Design Hoax", this book comprehensively refutes any notion of intelligent design by anything resembling a loving, intelligent and maximally good god. Such evil could not exist in a universe created by such a god. Evil exists, therefore a maximally good, all-knowing, all-loving god does not.
Illustrated by Catherine Webber-Hounslow.
The Unintelligent Designer: Refuting The Intelligent Design Hoax
ID is not a problem for science; rather science is a problem for ID. This book shows why. It exposes the fallacy of Intelligent Design by showing that, when examined in detail, biological systems are anything but intelligently designed. They show no signs of a plan and are quite ludicrously complex for whatever can be described as a purpose. The Intelligent Design movement relies on almost total ignorance of biological science and seemingly limitless credulity in its target marks. Its only real appeal appears to be to those who find science too difficult or too much trouble to learn yet want their opinions to be regarded as at least as important as those of scientists and experts in their fields.
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Human footprints at White Sands National Park in New Mexico, reported in 2021, show that human activity occurred in the Americas as long as 23,000 years ago – about 10,000 years earlier than previously thought. A new U of A study supports the 2021 findings.
Courtesy of David Bustos/ White Sands National Park
Fig. 3. Alkali Flat east escarpment.
(A) WHSA Locality 2 (view east) (Fig. 2B) with exposure of alluvial beds and palustrine beds along the escarpment. Stratum 1 is exposed in the foreground (comprising the eastern margin of Alkali Flat), but in this photo, it is dried out and covered with a thin sheet of eolian gypsum sand. The finely bedded sands and muds of Stratum 2A comprise the low escarpment in the middle ground, expressed by the thin, horizontal ledges formed by differential weathering of the stream beds. The trench exposing human tracks in Stratum 2A is at the left.
Fig. 1. Field area setting.
The northern Tularosa Basin showing the area of the White Sands (“Gypsum Sand Dunes”), the Alkali Fat deflation basin, modern Lake Lucero, and present-day Lost River, which drains southwest across the distal piedmont until it is buried by the gypsum dunes (see also fig. S4). The 1204-m contour line approximates the proposed extent of paleolake Otero (15). It was likely more extensive given the >4 m of lake beds at “G.” The two field areas (red dots) are as follows: “G” is the area of Gypsum Overlook, the Central study area, and WHSA Locality 2; “Loc 1” is a stratigraphic section along the west margin of Alkali Flat. The brown pattern at G is the area of exposures of deposits linked to paleolake Otero and overlain by truncated Holocene dunes (31). The inset shows the location of the White Sands and the Tularosa Basin within New Mexico [based on figure 1 in (31)].
The Bronze Age Middle Eastern authors of the Bible clearly knew little of the world beyond a few days' walk from their homes in the Canaanite Hills. The world they described — and the stories they invented to fill the vast gaps in their knowledge — contained nothing unfamiliar to them. They had no way of knowing the true age of the Earth or the Universe, which they imagined to be fixed and immobile. They knew nothing of the history of living or extinct species, nor of the compelling evidence for common ancestry stretching back hundreds of thousands, even tens of millions, of years. And they were entirely unaware of the existence of other peoples living in distant lands, across vast oceans on other continents.
It should come as no surprise, then, that they got so much wrong, and that their writings omitted nearly everything science has since revealed about human origins. We now know that Homo sapiens diversified from archaic ancestors in Africa and gradually spread across the globe—migrating over land bridges now submerged by rising sea levels and eventually reaching the Americas.
Almost all of this is well-established in modern science, with the only significant uncertainty remaining around the precise timing of the first human colonisation of the Americas from Siberia. Bible literalists attempt to sidestep this discrepancy between the scientific evidence and the biblical narrative by postulating, without any supporting evidence, that the Bible was authored by an omniscient creator god. They argue that any contradiction with scientific findings must be due to mistaken interpretation, not error in the Bible. In essence, their reasoning runs: “The Bible was written by an all-knowing god because the Bible says so—therefore, any conflicting evidence must be wrong.” Instead of critically examining the claims of Bronze Age hill farmers, they demand that science must bend to fit ancient, unsubstantiated assertions.
One striking example of the scientific evidence at odds with biblical literalism is the recent confirmation that human footprints discovered at White Sands National Park, New Mexico, are 23,000 years old—some 13,000 years older than biblical literalists believe the Earth itself to be.
These footprints were discovered in 2021 and initially dated to 23,000 years ago — 10,000 years earlier than the previously accepted earliest human presence in the Americas. While this early date was controversial, a team led by Professor Vance Holliday of the University of Arizona’s School of Anthropology and Department of Geosciences has now re-evaluated the evidence and confirmed the original finding.
The knee-jerk response from any creationist worth his or her salt, when shown evidence of observed instances of evolution, is to demand a redefinition of the term *evolution*—away from its scientific meaning of a change in allele frequency in a population over time, and towards the creationist’s caricature: a species instantaneously transforming into an entirely unrelated taxon. This is, of course, something evolutionary biologists have never claimed, and which—if it ever occurred—would actually refute the Theory of Evolution.
This is the all-too-familiar, disingenuous tactic of setting the bar impossibly high for one’s opponent, while keeping it at ground level for one’s own evidence-free superstition.
So, for those creationists more interested in finding workarounds to ease the cognitive dissonance between what they would like the facts to be and what science actually shows, than learning the truth about the world around us, the news that researchers at Chicago’s Field Museum have demonstrated evolutionary change in the city’s rodent populations over the last 125 years will likely present little difficulty. They can always chant, “But it’s still a chipmunk/vole/etc., so not evolution!”
However, for those with the intellectual integrity and humility to base their opinions on observable evidence, rather than dismissing any evidence that doesn't conform to their preconceived alternative reality, this finding is a compelling vindication of a basic principle of the Theory of Evolution: that species change over time in response to environmental pressures.
The researchers have recently published their findings in the journal Integrative & Comparative Biology.
The mountain of evidence that creationists must ignore to maintain their belief that Earth is a mere 6,000–10,000 years old—because it says so in a book of Bronze Age mythology—just got a little bigger. A new analysis of the DNA of two frozen canid cubs found in Siberian permafrost confirms they were wolves, not early domesticated dogs as once speculated. The cubs, discovered near the village of Tumat in northern Siberia, are around 14,000 years old and genetically similar to modern wolves.
An analysis of DNA from their stomach contents reveals a mixed diet of meat and plant matter, consistent with the diets of contemporary wolves. Remarkably, some of the meat—specifically skin—came from a woolly rhinoceros, likely a calf, as adult rhinos would have been far too large for wolves to hunt. An earlier study had identified black fur in the cubs, prompting speculation that they might be early domesticated dogs, since melanism is commonly associated with dogs but not typically seen in wolves. However, further genomic analysis showed that these cubs belonged to a now-extinct wolf population that was not ancestral to domestic dogs. This suggests the black fur mutation may have been limited to that specific lineage, contributing nothing to the modern dog gene pool.
The puppies were found at the Syalakh site, the first in 2011 and the second in 2015. The site also contains mammoth bones showing signs of burning and processing by humans. This initially led to speculation that the cubs might have been tame or semi-domesticated wolves associated with early humans. However, that hypothesis can now be ruled out based on the genetic evidence. It is believed that the cubs died when a landslide trapped them in their den shortly after their final meal.
How the wolf cubs came to be fed on the skin of a woolly rhinoceros remains uncertain, but one plausible explanation is that it was scavenged from a kill made by humans.
