Malevolent Designer News - How A Bacterium Is 'Intelligently Designed' To Spread Disease

Blacklegged tick, Ixodes scapularis

Bacteria hijack tick cell defenses to spread disease | WSU Insider

Here we have yet another example demonstrating that, if we apply Discovery Institute fellow William A. Dembski's criteria for proving intelligent design — namely the presence of complex specified genetic information — then we must conclude that creationism's supposed intelligent designer is, in fact, a malevolent force devising ever more sophisticated ways to inflict suffering on the world.

Once again, honest creationists are left with a stark dilemma: either complex specified information is indeed evidence of design, in which case the designer is malevolent, or it is not, in which case a central tenet of Intelligent Design creationism collapses. The dishonest ones, of course, will simply dismiss the evidence, likely misrepresent the science, and continue to bear false witness against scientists. In neither case should we expect creationists to admit that the theory of evolution fully accounts for the appearance of "malevolent" design, arising naturally without conscious intent or divine interference.

It’s a curious paradox that people who claim to worship the God of the Bible as an omnibenevolent, anthropophilic being are so often willing to see that deity cast in the role of a malevolent agent—so long as they can reject the theory of evolution. This strongly suggests that their opposition to evolution is not primarily theological, but political.

The latest example comes from the tick-borne pathogen Anaplasma, which causes anaplasmosis and contributes to Lyme disease. This bacterium hijacks the cellular machinery of ticks to ensure its own survival and transmission to new hosts, including humans. Although Dembski has famously avoided providing a rigorous, testable definition of "complex specified genetic information," any such definition would surely encompass genetic adaptations that promote survival and reproduction.

This discovery was made by researchers at the College of Veterinary Medicine, Washington State University (WSU). Their findings have just been published in Proceedings of the National Academy of Sciences (PNAS) and are explained in lay terms in WSU Insider, the university's online news outlet.

What information do you have on Anaplasma and the tick that transmits it? Anaplasma is a genus of bacteria that includes several species capable of causing disease in humans and animals. The most medically relevant species is Anaplasma phagocytophilum, which causes anaplasmosis—a tick-borne disease that affects both humans and various mammals.

1. Overview of Anaplasma
   • Anaplasma are obligate intracellular bacteria in the family Anaplasmataceae.
   • They primarily infect white blood cells (especially neutrophils in the case of A. phagocytophilum).
   • Disease is often seasonal, peaking during the months of high tick activity (late spring to early autumn in temperate zones).
   
   
2. Disease in Humans
   • Caused mainly by Anaplasma phagocytophilum.
   • Known as Human Granulocytic Anaplasmosis (HGA).
   • Symptoms include:
     • Fever, chills, headache
     • Muscle aches
     • Malaise
     • Occasionally gastrointestinal symptoms (nausea, vomiting)
     • In severe cases: respiratory failure, organ failure, neurological symptoms
   • Incubation period: ~5–14 days after a tick bite.
   • Treatment: Responds well to doxycycline, especially if started early.
   • If untreated, it can lead to complications, especially in the elderly or immunocompromised.
   
   
3. Tick Vectors
   • The primary vector in the United States is the blacklegged tick (Ixodes scapularis), also called the deer tick.
   • In Europe, the main vector is the castor bean tick (Ixodes ricinus).
   • These are the same ticks that transmit Lyme disease (Borrelia burgdorferi) and Babesia (babesiosis), leading to frequent co-infections.
   
   
4. Hosts and Reservoirs
   • Main animal reservoirs include:
     • White-tailed deer
     • Rodents
     • Small mammals
   • Ticks acquire the bacteria when feeding on an infected host and then transmit it during subsequent feedings.
   
   
5. Biological Strategy of the Pathogen
   
   Recent research (such as the 2025 WSU referenced) shows that Anaplasmacan:
   • Hijack the tick's cellular defence mechanisms, particularly its oxidative stress response, allowing the bacteria to survive within the tick's gut.
   • Manipulate the cell death pathways of tick cells, suppressing apoptosis (programmed cell death) to extend the viability of the cells it infects.
   • Modify gene expression in the tick to enhance its own survival and transmission potential.
   
   These mechanisms qualify as highly sophisticated biological strategies—precisely the sort of adaptations that Intelligent Design proponents would struggle to explain without appealing to either special pleading or malevolent intent.
   
   
6. Ecological and Public Health Impact
   • Geographic spread is increasing, partly due to climate change, which expands the habitat range of ticks.
   • Public health monitoring is challenged by co-infections and misdiagnosis (HGA is often confused with Lyme disease or viral infections).
   • Preventative strategies include tick checks, repellents, and public awareness campaigns.

Bacteria hijack tick cell defenses to spread disease

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Washington State University researchers have discovered how the bacteria that cause anaplasmosis and Lyme disease hijack cellular processes in ticks to ensure their survival and spread to new hosts, including humans.

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Based in the College of Veterinary Medicine, the team found that the bacteria can manipulate a protein known as ATF6, which helps cells detect and respond to infection, to support its own growth and survival inside the tick. The findings, published in the journal Proceedings of the National Academy of Sciences, could serve as a launching point for developing methods to eliminate the bacteria in ticks before they are transmitted to humans and other animals.

Most research has looked at how these bacteria interact with humans and animals and not how they survive and spread in ticks. What we have found could open the door to targeting these pathogens in ticks, before they are ever a threat to people.

Kaylee A. Vosbigian, lead author
Department of Veterinary Microbiology and Pathology
College of Veterinary Sciences
Washington State University, Pullman, WA, USA.

Vosbigian and her advisor, Dana Shaw, the corresponding author of the study and an associate professor in the Department of Veterinary Microbiology and Pathology, focused their research on Ixodes scapularis, also known as the black-legged tick, which is responsible for spreading both Anaplasma phagocytophilum and Borrelia burgdorferi, the causative agents of anaplasmosis and Lyme disease. Both diseases are becoming increasingly common and can cause serious illness in humans and animals.

The team discovered that when ATF6 is activated in tick cells, it triggers the production of stomatin, a protein that helps move cholesterol through cells as part of a normal cellular processes. The bacteria exploit this process against their tick hosts, using the cholesterol — which they need to grow and build their own cell membranes but cannot produce themselves — to support their own survival and success.

Stomatin plays a variety of roles in the cell, but one of its key functions is helping shuttle cholesterol to different areas. The bacteria take advantage of this, essentially stealing the cholesterol they need to survive.

Kaylee A. Vosbigian

When the researchers blocked the production of stomatin, restricting the availability of cholesterol, bacterial growth is significantly reduced. The researchers believe this shows targeting the ATF6-stomatin pathway could lead to new methods for interrupting the disease cycle in ticks before transmission occurs.

As part of the study, Vosbigian also developed a new research tool called ArthroQuest, a free, web-based platform hosted by WSU that allows scientists to search the genomes of ticks, mosquitoes, lice, sand flies, mites, fleas and other arthropod vectors for transcription factor binding sites — genetic switches like ATF6 that control gene activity.

There aren’t many tools out there for studying gene regulation in arthropods. Most are built for humans or model species like fruit flies, which are genetically very different from ticks.

Kaylee A. Vosbigian

Using ArthroQuest, the team found that ATF6-regulated control of stomatin appears to be prevalent in blood-feeding arthropods. Since the hijacking of cholesterol and other lipids is common among arthropod-borne pathogens, the researchers suspect many may also exploit ATF6.

We know many other vector-borne pathogens, like Borrelia burgdorferi and the malaria-causing parasite Plasmodium, rely on cholesterol and other lipids from their hosts. So, the fact that this ATF6-stomatin pathway exists in other arthropods could be relevant to a wide range of disease systems.

Assistant Professor Dana K. Shaw, corresponding author.
Department of Veterinary Microbiology and Pathology
College of Veterinary Sciences
Washington State University, Pullman, WA, USA.

Publication:

K.A. Vosbigian,S.J. Wright,B.P. Steiert,K.L. Rosche,E.A. Fisk,E. Ramirez-Zepp,J.M. Park,E.A. Shelden,& D.K. Shaw
ATF6 enables pathogen infection in ticks by inducing stomatin and altering cholesterol dynamics
Proc. Natl. Acad. Sci. U.S.A. 122 (25) e2501045122, https://doi.org/10.1073/pnas.2501045122 (2025).

Significance
Infection dynamics for tick-borne pathogens like Anaplasma have primarily been studied in mammals. Comparatively less is known about tick–pathogen interactions. We found that Anaplasma activates the stress response receptor, ATF6, in ticks. Activated ATF6 functions as a transcriptional regulator. Using a custom script in R, we identified stomatin as an ATF6-regulated target that supports Anaplasma by modulating cholesterol trafficking. Our custom tool “ArthroQuest” revealed that the ATF6-regulated nature of stomatin is unique to arthropods. Given that lipid hijacking is common among arthropod-borne microbes, ATF6-mediated induction of stomatin may be exploited in many vector–pathogen relationships. In addition, our findings predict that there are many ATF6-regulated genes unique to ticks, highlighting that there is still much to be uncovered.

Abstract
How tick-borne pathogens interact with their hosts has been primarily studied in vertebrates where disease is observed. Comparatively less is known about pathogen interactions within the tick. Here, we report that Ixodes scapularis ticks infected with either Anaplasma phagocytophilum (causative agent of anaplasmosis) or Borrelia burgdorferi (causative agent of Lyme disease) show activation of the ATF6 branch of the unfolded protein response (UPR). Disabling ATF6 functionally restricts pathogen survival in ticks. When stimulated, ATF6 functions as a transcription factor, but is the least understood out of the three UPR pathways. To interrogate the Ixodes ATF6 transcriptional network, we developed a custom R script to query tick promoter sequences. This revealed stomatin as a potential gene target, which has roles in lipid homeostasis and vesical transport. Ixodes stomatin was experimentally validated as a bona fide ATF6-regulated gene through luciferase reporter assays, pharmacological activators, RNA interference transcriptional repression, and immunofluorescence microscopy. Silencing stomatin decreased A. phagocytophilum colonization in Ixodes and disrupted cholesterol dynamics in tick cells. Furthermore, blocking stomatin restricted cholesterol availability to the bacterium, thereby inhibiting growth and survival. Taken together, we have identified the Ixodes ATF6 pathway as a contributor to vector competence through Stomatin-regulated cholesterol homeostasis. Moreover, our custom, web-based transcription factor binding site search tool “ArthroQuest” revealed that the ATF6-regulated nature of stomatin is unique to blood-feeding arthropods. Collectively, these findings highlight the importance of studying fundamental processes in nonmodel organisms.

The North American deer tick, Ixodes scapularis, can transmit up to seven different pathogens that impact human and animal health including Anaplasma phagocytophilum (causative agent of anaplasmosis) and Borrelia burgdorferi (causative agent of Lyme disease) (1). The continuous rise in reported cases of tick-borne disease (2–10) underscores the need for novel intervention strategies. Although the intricacies of mammalian host–pathogen interactions have been well studied, comparatively little is known about tick–pathogen interactions.

Recently we have shown that A. phagocytophilum and B. burgdorferi activate the unfolded protein response (UPR) in ticks, which influences microbial colonization and persistence in the arthropod (11, 12). The UPR is a cellular response network that is initiated by three endoplasmic reticulum (ER) transmembrane receptors IRE1α, PERK, and ATF6. Each branch of the UPR initiates a signaling cascade and coordinates gene expression networks by activating specific transcription factors. We have shown that the IRE1α-TRAF2 pathway leads to microbe-restricting immune responses in arthropods by activating the NF-κB-like molecule, Relish (11). We have also demonstrated that stimulating PERK activates the antioxidant transcription factor, Nrf2, which facilitates pathogen persistence in ticks (12). Out of the three UPR receptors, ATF6 is the least understood (13). When activated, site-1 and site-2 proteases cleave the cytosolic portion of ATF6, which allows it to translocate to the nucleus and act as a transcriptional regulator (nATF6) (14). The role of ATF6 has never been explored in arthropod vectors.

Here, we demonstrate that Ixodes ATF6 is activated by tick-borne pathogens and supports A. phagocytophilum colonization in ticks. To determine how ATF6 impacts vector competence, we used protein modeling and a custom transcription factor binding site query to probe the ATF6 regulatory network in I. scapularis. Gene ontology (GO) and Reactome analyses identified Stomatin, a lipid homeostasis and vesical transport protein, as a potential gene regulated by ATF6 in ticks. Using pharmacological manipulations, RNA interference (RNAi), quantitative fluorescent assays, and immunofluorescence microscopy, we found that Stomatin supports pathogen colonization in ticks by facilitating cholesterol acquisition by the bacterium. These findings demonstrate that stomatin is induced during the arthropod-phase of the pathogen life cycle to enable survival and persistence in the vector.

Programs that predict transcription factor regulatory networks are generally restricted to model organisms, leaving out many arthropod vectors. We used our custom R script to develop a publicly available, web-based tool termed “ArthroQuest” that currently allows users to query 20 different arthropod vector genomes, in addition to Drosophila and humans. Queries with ArthroQuest revealed that the ATF6-regulated nature of stomatin appears to be unique to arthropods. Given that lipid hijacking and cholesterol incorporation is common in many arthropod-borne microbes (15), ATF6-mediated induction of stomatin may be a shared phenomenon among many vector–pathogen relationships that is exploited for the survival and persistence of transmissible pathogens.

K.A. Vosbigian,S.J. Wright,B.P. Steiert,K.L. Rosche,E.A. Fisk,E. Ramirez-Zepp,J.M. Park,E.A. Shelden,& D.K. Shaw
ATF6 enables pathogen infection in ticks by inducing stomatin and altering cholesterol dynamics
Proc. Natl. Acad. Sci. U.S.A. 122 (25) e2501045122, https://doi.org/10.1073/pnas.2501045122 (2025).

Copyright: ©2025 The authors.
Published by the National Academy of Sciences of the USA. Open access.
Reprinted under a Creative Commons Attribution 4.0 International license (CC BY 4.0)

This discovery poses a significant problem for proponents of Intelligent Design (ID) creationism because it challenges one of their core assertions: that complex specified information (CSI) within genetic material is a reliable indicator of an intelligent, purposeful designer. If we accept this premise, then we are compelled to ask why such intelligence would devote itself to crafting mechanisms that cause suffering, disease, and death—such as the ability of Anaplasma to hijack tick cell defences and ensure its own propagation at the expense of both ticks and mammalian hosts, including humans.

The usual ID response is to insist that their designer is benevolent — typically equated with the God of the Bible. But here, we are faced with a biological system so well-adapted to spreading infection that it must either be acknowledged as a product of evolutionary processes or attributed to a designer with malevolent intent. This is not a fringe example; it is one of many cases where nature reveals a level of intricate adaptation that ID advocates would normally cite as evidence for design, were it not so profoundly disturbing.

What this ultimately reveals is the theological inconsistency at the heart of ID creationism. The refusal to acknowledge the explanatory power of evolution, even when confronted with examples like Anaplasma, indicates that ID is not a scientific theory but a religious or ideological stance. The selective application of their own criteria — applauding "design" in butterflies but ignoring it in parasites — exposes the intellectual dishonesty behind the movement. Evolution, by contrast, provides a consistent and naturalistic framework that explains both the beautiful and the brutal features of the living world — without invoking a morally compromised designer.

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The Malevolent Designer: Why Nature's God is Not Good

This book presents the reader with multiple examples of why, even if we accept Creationism's putative intelligent designer, any such entity can only be regarded as malevolent, designing ever-more ingenious ways to make life difficult for living things, including humans, for no other reason than the sheer pleasure of doing so. This putative creator has also given other creatures much better things like immune systems, eyesight and ability to regenerate limbs that it could have given to all its creation, including humans, but chose not to. This book will leave creationists with the dilemma of explaining why evolution by natural selection is the only plausible explanation for so many nasty little parasites that doesn't leave their creator looking like an ingenious, sadistic, misanthropic, malevolence finding ever more ways to increase pain and suffering in the world, and not the omnibenevolent, maximally good god that Creationists of all Abrahamic religions believe created everything. As with a previous book by this author, "The Unintelligent Designer: Refuting the Intelligent Design Hoax", this book comprehensively refutes any notion of intelligent design by anything resembling a loving, intelligent and maximally good god. Such evil could not exist in a universe created by such a god. Evil exists, therefore a maximally good, all-knowing, all-loving god does not.

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The Unintelligent Designer: Refuting The Intelligent Design Hoax

ID is not a problem for science; rather science is a problem for ID. This book shows why. It exposes the fallacy of Intelligent Design by showing that, when examined in detail, biological systems are anything but intelligently designed. They show no signs of a plan and are quite ludicrously complex for whatever can be described as a purpose. The Intelligent Design movement relies on almost total ignorance of biological science and seemingly limitless credulity in its target marks. Its only real appeal appears to be to those who find science too difficult or too much trouble to learn yet want their opinions to be regarded as at least as important as those of scientists and experts in their fields.

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Refuting Creationism - Evidence of Humans In America 13,000 Years Before 'Creation Week'

Human footprints at White Sands National Park in New Mexico, reported in 2021, show that human activity occurred in the Americas as long as 23,000 years ago – about 10,000 years earlier than previously thought. A new U of A study supports the 2021 findings.

Courtesy of David Bustos/
White Sands National Park

Earliest evidence of humans in the Americas confirmed in new U of A study | University of Arizona News

Fig. 3. Alkali Flat east escarpment.
(A) WHSA Locality 2 (view east) (Fig. 2B) with exposure of alluvial beds and palustrine beds along the escarpment. Stratum 1 is exposed in the foreground (comprising the eastern margin of Alkali Flat), but in this photo, it is dried out and covered with a thin sheet of eolian gypsum sand. The finely bedded sands and muds of Stratum 2A comprise the low escarpment in the middle ground, expressed by the thin, horizontal ledges formed by differential weathering of the stream beds. The trench exposing human tracks in Stratum 2A is at the left.

Vance T. Holliday et al.(2025)

Fig. 1. Field area setting.
The northern Tularosa Basin showing the area of the White Sands (“Gypsum Sand Dunes”), the Alkali Fat deflation basin, modern Lake Lucero, and present-day Lost River, which drains southwest across the distal piedmont until it is buried by the gypsum dunes (see also fig. S4). The 1204-m contour line approximates the proposed extent of paleolake Otero (15). It was likely more extensive given the >4 m of lake beds at “G.” The two field areas (red dots) are as follows: “G” is the area of Gypsum Overlook, the Central study area, and WHSA Locality 2; “Loc 1” is a stratigraphic section along the west margin of Alkali Flat. The brown pattern at G is the area of exposures of deposits linked to paleolake Otero and overlain by truncated Holocene dunes (31). The inset shows the location of the White Sands and the Tularosa Basin within New Mexico [based on figure 1 in (31)].

Image credit: X. Gong and A. Cowart, University of Wisconsin Cartography Lab.
Vance T. Holliday et al.(2025)

The Bronze Age Middle Eastern authors of the Bible clearly knew little of the world beyond a few days' walk from their homes in the Canaanite Hills. The world they described — and the stories they invented to fill the vast gaps in their knowledge — contained nothing unfamiliar to them. They had no way of knowing the true age of the Earth or the Universe, which they imagined to be fixed and immobile. They knew nothing of the history of living or extinct species, nor of the compelling evidence for common ancestry stretching back hundreds of thousands, even tens of millions, of years. And they were entirely unaware of the existence of other peoples living in distant lands, across vast oceans on other continents.

It should come as no surprise, then, that they got so much wrong, and that their writings omitted nearly everything science has since revealed about human origins. We now know that Homo sapiens diversified from archaic ancestors in Africa and gradually spread across the globe—migrating over land bridges now submerged by rising sea levels and eventually reaching the Americas.

Almost all of this is well-established in modern science, with the only significant uncertainty remaining around the precise timing of the first human colonisation of the Americas from Siberia. Bible literalists attempt to sidestep this discrepancy between the scientific evidence and the biblical narrative by postulating, without any supporting evidence, that the Bible was authored by an omniscient creator god. They argue that any contradiction with scientific findings must be due to mistaken interpretation, not error in the Bible. In essence, their reasoning runs: “The Bible was written by an all-knowing god because the Bible says so—therefore, any conflicting evidence must be wrong.” Instead of critically examining the claims of Bronze Age hill farmers, they demand that science must bend to fit ancient, unsubstantiated assertions.

One striking example of the scientific evidence at odds with biblical literalism is the recent confirmation that human footprints discovered at White Sands National Park, New Mexico, are 23,000 years old—some 13,000 years older than biblical literalists believe the Earth itself to be.

These footprints were discovered in 2021 and initially dated to 23,000 years ago — 10,000 years earlier than the previously accepted earliest human presence in the Americas. While this early date was controversial, a team led by Professor Vance Holliday of the University of Arizona’s School of Anthropology and Department of Geosciences has now re-evaluated the evidence and confirmed the original finding.

The team has just published their findings, open access, in Science, with an explanation in an official University of Arizona news release.

Refuting Creationism - Observed Evolution Over 125 Years!

Skull and skin from a vole, collected in 1898 in Chicago.

Authors Stephanie Smith and Anderson Feijó examining chipmunk specimens in the Field Museum’s collections.

Chicago’s rodents are evolving to handle city living - Field Museum

The knee-jerk response from any creationist worth his or her salt, when shown evidence of observed instances of evolution, is to demand a redefinition of the term *evolution*—away from its scientific meaning of a change in allele frequency in a population over time, and towards the creationist’s caricature: a species instantaneously transforming into an entirely unrelated taxon. This is, of course, something evolutionary biologists have never claimed, and which—if it ever occurred—would actually refute the Theory of Evolution.

This is the all-too-familiar, disingenuous tactic of setting the bar impossibly high for one’s opponent, while keeping it at ground level for one’s own evidence-free superstition.

So, for those creationists more interested in finding workarounds to ease the cognitive dissonance between what they would like the facts to be and what science actually shows, than learning the truth about the world around us, the news that researchers at Chicago’s Field Museum have demonstrated evolutionary change in the city’s rodent populations over the last 125 years will likely present little difficulty. They can always chant, “But it’s still a chipmunk/vole/etc., so not evolution!”

However, for those with the intellectual integrity and humility to base their opinions on observable evidence, rather than dismissing any evidence that doesn't conform to their preconceived alternative reality, this finding is a compelling vindication of a basic principle of the Theory of Evolution: that species change over time in response to environmental pressures.

The researchers have recently published their findings in the journal Integrative & Comparative Biology.

Creationism Refuted - Now It's Frozen Wolf Cubs From 4,000 Years Before 'Creation Week'

14,000-year-old frozen wolf cubs recovered from permafrost at the Syalakh site, Northern Siberia

Famous Ice Age ‘puppies’ likely wolf cubs and not dogs, study shows - News and events, University of York

The mountain of evidence that creationists must ignore to maintain their belief that Earth is a mere 6,000–10,000 years old—because it says so in a book of Bronze Age mythology—just got a little bigger. A new analysis of the DNA of two frozen canid cubs found in Siberian permafrost confirms they were wolves, not early domesticated dogs as once speculated. The cubs, discovered near the village of Tumat in northern Siberia, are around 14,000 years old and genetically similar to modern wolves.

An analysis of DNA from their stomach contents reveals a mixed diet of meat and plant matter, consistent with the diets of contemporary wolves. Remarkably, some of the meat—specifically skin—came from a woolly rhinoceros, likely a calf, as adult rhinos would have been far too large for wolves to hunt. An earlier study had identified black fur in the cubs, prompting speculation that they might be early domesticated dogs, since melanism is commonly associated with dogs but not typically seen in wolves. However, further genomic analysis showed that these cubs belonged to a now-extinct wolf population that was not ancestral to domestic dogs. This suggests the black fur mutation may have been limited to that specific lineage, contributing nothing to the modern dog gene pool.

The puppies were found at the Syalakh site, the first in 2011 and the second in 2015. The site also contains mammoth bones showing signs of burning and processing by humans. This initially led to speculation that the cubs might have been tame or semi-domesticated wolves associated with early humans. However, that hypothesis can now be ruled out based on the genetic evidence. It is believed that the cubs died when a landslide trapped them in their den shortly after their final meal.

How the wolf cubs came to be fed on the skin of a woolly rhinoceros remains uncertain, but one plausible explanation is that it was scavenged from a kill made by humans.

Refuting Creationism - Biofluorescent fish 112 Million Years Before 'Creation Week'.

A tropical striped triplefin, Helcogramma striata.

© John Sparks and David Gruber

Creationists bunker - Evidence keep out! No Science Allowed!

Studies Reveal Fish Biofluorescence Dates Back 112 Million Years | AMNH

I sometimes imagine creationists hiding inside a bunker with no windows, completely cut off from the reality outside, where a torrential rainstorm is underway. From within their sealed refuge, they declare to themselves—and to the world outside—that there is no evidence of rain, simply because they can’t see any.

Their only source of information is a handful of picture books depicting a tropical paradise where it never rains, so they believe everything beyond their bunker must be warm and sunny—just as the picture books describe. Anyone who tells them otherwise, or tries to show them a different picture, must be lying to trick them.

How else can creationists be so insulated from the reality of the deluge of scientific evidence in the real world?

That slightly tortured analogy is by way of introducing another couple of scientific papers concerning the evolutionary divergence of the phenomenon of biofluorescence. Unlike bioluminescence—where light is produced by a physiological process using ATP and functions in total darkness—biofluorescence involves the absorption of ambient light, which is then re-emitted at a different frequency. Specialised proteins absorb this light energy, become unstable in their excited state, and return to their ground state by releasing photons—hence biofluorescence functions in low-light conditions.

Fish in particular, but also sea turtles and corals, use these glowing patterns as signals—for attracting mates, confusing predators, and more. According to two newly published papers by a team led by researchers at the American Museum of Natural History (AMNH), this phenomenon first emerged around 112 million years ago—once again, firmly within Earth’s long pre–'Creation Week' history. Since then, biofluorescence appears to have evolved independently up to 100 times, a clear indication of its adaptive benefits in dimly lit ocean environments.

Beyond the evidence for biological activity in a time creationists claim the Earth didn’t even exist, there's another uncomfortable detail for them: the researchers declare that to understand the pattern of bioluminescence in nature, “...we need to understand the underlying evolutionary story...” Not something a creationist, labouring under the delusion that biologists are abandoning the theory of evolution in favour of creationism, would want to read.

Their findings are published open access in Nature Communications and PLOS ONE.

Refuting Creationism - How Living Organism's Survived - 700 Million Years Before 'Creation Week'

Researchers Ian Hawes of the University of Waikato and Marc Schallenberg of the University of Otago measure the physicochemical conditions of a meltwater pond.

Credit: Roger Summons

Pustular microbial mat section such as could have existend in small melt-water ponds.

When Earth iced over, early life may have sheltered in meltwater ponds | MIT News | Massachusetts Institute of Technology

Only by systematically ignoring geological and archaeological evidence can creationists continue to delude themselves into believing that Earth is just a few thousand years old and was perfectly created by an anthropophilic god especially for humans – its supposed “special creation.”

The evidence, however, paints a radically different picture from that childish superstition. Not only was Earth clearly not perfectly created for humans, it wasn’t perfectly created for any life form. And it is far older than creationists assert. In truth, around 600 million years ago, Earth was such a hostile place for life that it was entirely covered in ice. The polar ice sheets had extended until they met at the equator. These “Snowball Earth” conditions led to a mass extinction so severe that it remains something of a mystery how any life survived – especially complex eukaryotic cells.

Now, a multinational team of researchers led by scientists from the Massachusetts Institute of Technology (MIT) has found evidence that early life could have survived in small pools of surface meltwater. They reached this conclusion after studying similar meltwater pools on the McMurdo Ice Shelf in Antarctica. What they found not only showed that single-celled eukaryotes can survive in such conditions, but also revealed that the population of prokaryotes varies according to local environmental conditions

These meltwater pools act as microcosms of diverse environments and demonstrate how local factors shape the distribution of different species – exactly as predicted by the Theory of Evolution. Had the conditions been perfect as creationists insist, there could be no variation in the populations in these pools. Variation only arises because the species need to adapt to different conditions - something that would never be needed in perfectly designed conditions.

The team has just published their findings, open access, in the journal Nature Communications.

Malevolent Designer News - How Cold Sores Are Cleverly Designed To Maximise Suffering.

The human genome compacted inside cells
eight hours after infection.

Credit: Esther González Almela
and Álvaro Castells García

(Top) Cropped representative STORM-PAINT images of EdC-AF647 labeled hDNA (magenta), immunolabeled H3 (green), and their merge in mock and HSV-1 infected A549 cells. Scale bar: 2 µm. (Bottom) Zoomed-in regions are shown inside yellow boxes. Scale bar: 200 nm.

González-Almela, E., Castells-Garcia, A., Le Dily, F. et al. (2025)

Centre for Genomic Regulation Website

One of the many problems with Intelligent Design (ID) creationism is its complete failure to account for evolutionary arms races.

According to leading ID proponents like William A. Dembski and Michael J. Behe, living organisms and their parasites — including viruses — must have been intelligently designed because they are supposedly “irreducibly complex” and exhibit “complex specified information”. But if that were true, it would mean the same designer is deliberately crafting both parasites and the defence mechanisms their hosts use to fend them off — hardly the mark of a supremely intelligent creator.

A further problem, and one that creationists prefer to ignore, is theological: designing pathogens like viruses is fundamentally incompatible with the notion of a benevolent creator. In fact, it suggests a malevolent intelligence — one more concerned with maximising suffering than promoting life and maximising happiness. So, when science uncovers yet another example of a virus behaving with surgical precision and apparent ingenuity, ID creationists find themselves in a bind. Is irreducible complexity and complex specified genetic information not evidence of intelligent design after all? Or must they admit that the designer is, at best, morally indifferent — or worse, actively malevolent?

The latest headache for the ID camp comes courtesy of the Herpes simplex virus — the one responsible for cold sores. Researchers at the Centre for Genomic Regulation (CRG) in Barcelona, Catalunya, Spain, with colleagues in Guangdong Provincial People’s Hospital, Guangdong, China, have discovered that the virus can radically reorganise a host cell’s genetic architecture — and it does so using the host's own cellular machinery. Their findings have just been published open access in Nature Communications.

Refuting Creationism - Confirmation of A Denisovan Skull - Homo longi

A reconstruction of Homo longi from the ancient Harbin skull found in China.

Image credit: John Bavaro Fine Art
Science Photo Library

Figure 1 The geographic locations and proteomic profiles for the Pleistocene hominin individuals with palaeoproteomic data.

The Middle Pleistocene cranium recovered in Harbin, Heilongjiang Province, northeastern China.

Key Evidence Links Harbin Individual's Nearly Complete Skull to a Denisovan--Institute of Vertebrate Paleontology and Paleoanthropology.

One of the enduring problems with the Denisovans has been the lack of substantial physical evidence. Although their existence was first confirmed through DNA analysis of a finger bone discovered in the Denisova Cave in Siberia, and genetic traces of interbreeding with Homo sapiens are widespread throughout Southeast Asia and Melanesia—suggesting a remarkably adaptable and far-ranging hominin—fossil evidence has remained frustratingly scant. Beyond the Siberian finger bone, we have only a few bone fragments from a cave on the Tibetan Plateau and a jawbone dredged up by fishermen off the coast of Taiwan. These scattered remnants were insufficient to assign a clear taxonomic identity, so the group remained simply ‘the Denisovans’.

That gap in the fossil record now appears to have been dramatically narrowed. A near-complete skull, dubbed the 'Harbin skull'—also known as 'Dragon Man' or Homo longi—has now been identified as belonging to a Denisovan. This remarkable specimen, found in northeastern China, may finally give the Denisovans a face and, by the conventions of biological nomenclature, the name Homo longi. Since it is the most complete and morphologically distinct fossil now associated with the group, Homo longi may become the formal species name, superseding the informal label ‘Denisovan’.

Of course, Denisovans pose an even greater challenge to creationist dogma than they ever did to palaeoanthropology. Their existence is fundamentally at odds with the belief that all humans descend from a single ancestral couple who committed the so-called Original Sin, for which redemption is supposedly possible only through accepting the mythologised sacrifice of Jesus. The evidence now shows not only that there was no original couple, but that there wasn’t even a single founding species. Modern non-African humans are the product of complex interbreeding events between at least three archaic human lineages—thousands of years before the Earth was allegedly created, according to young-Earth creationist timelines.

The identification of the Harbin skull as Denisovan has just been published by researchers from the Institute of Vertebrate Paleontology and Paleoanthropology in Beijing, China. Their findings appear in papers in Cell and Science, and in a news release from the Chinese Academy of Sciences Institute of Vertebrate Paleontology and Paleoanthropology.

Creationism Refuted - How The Survivors of a Mass Extinction Evolved Into Dinosaurs

Euparkeria capensis, a small, 60 cm long reptile from the early Triassic period (245 - 237 million years ago).

Credit: Taenadoman, 2011
via Wikimedia Commons
CC A-SA 3.0

Triassic reptiles took 10,000 mile trips through “hellish” conditions, study suggests - University of Birmingham

Contrary to the child-like naivety and carefully cultivated ignorance of creationists, Earth is not — and never has been — a paradise perfectly designed for life, let alone tailor-made for humans. In reality, the vast majority of Earth's history — around 99.9975% of it — took place long before creationists believe the planet even existed, during which time the environment has frequently become so hostile that mass extinctions wiped out the majority of living species. Life as we know it today descends from the lucky few that managed to survive and adapt to radically altered conditions.

One of the most devastating of these extinction events was the end-Permian climate catastrophe, during which one group of reptiles — the archosauromorphs — managed to endure. From this resilient lineage emerged the dinosaurs, who would go on to dominate the planet until they too were annihilated by a cataclysmic meteor impact 66 million years ago.

While palaeontologists have long known about the survival and evolutionary significance of archosauromorphs, a lingering mystery remained: how did they manage to disperse across vast "dead zones" of the tropics, where temperatures were thought to be lethally high? A new study by researchers from the University of Birmingham and the University of Bristol has now shed light on this question. Their findings have been published, open access, in Nature Ecology & Evolution.

Refuting Creationism - How One Of Our Ancestral Species Travelled Across Eurasia

Simulations show Neanderthals likely traveled over 2,000 miles in just 2,000 years using natural corridors like rivers.

Credit: Shutterstock

Computer simulated paths of Neanderthal dispersals demonstrate they could have reached the Altai Mountains in Siberia within 2,000 years during warm climatic conditions in one of two ancient time periods—MIS 5e (approximately 125,000 years ago) or MIS 3 (approximately 60,000 years ago)—as demonstrated by the three different possible paths shown here. These paths follow a northern route through the Ural Mountains and southern Siberia, often intersecting with known archaeological sites from the same time periods.

Image: Emily Coco and Radu Iovita.

Anthropologists Map Neanderthals’ Long and Winding Roads Across Europe and Eurasia

One of the ancestral species of all non-African Homo sapiens, the Neanderthals, migrated across Eurasia from Central Europe to Central Asia between 120,000 and 60,000 years ago. In the Altai Mountains of Siberia, they encountered the Denisovans and interbred with them—just as they would later interbreed with Homo sapiens migrating northwards out of Africa some 20,000 years later.

This is the fascinating history of our cousin species, now being brought to light by researchers at New York University’s Centre for the Study of Human Origins.

It almost goes without saying that this, along with the very existence of Neanderthals and their interbreeding with Eurasian Homo sapiens, is entirely incompatible with basic creationist beliefs and a literal reading of the Bible. Like all scientific discoveries, however, it fits seamlessly with what we already know and further enriches our understanding of both Neanderthal life and our own evolutionary history.

The discovery also addresses one of the long-standing mysteries surrounding Neanderthal dispersal during the Ice Age—namely, how they migrated from their central European ‘homelands’ to the Altai Mountains in Central Asia, where they interbred with Denisovans in what was likely the northern limit of the Denisovans’ range. Until now, their migration route had remained unclear due to a lack of archaeological evidence.

The breakthrough comes from computer simulations, which reveal a network of habitable valleys that connected Central Europe to Central Asia during a warmer period lasting some 2,000 years—long enough for Neanderthals to have reached within 600 kilometres of the Altai Mountains. The New York anthropologists have recently published their findings in the journal PLOS One.

Refuting Creationism - Yes, It's Another Of Those 'Non-Exitent' Transitional Fossils!

Reconstruction of the Burgess Shale concilitergan Helmetia expansa.

Artwork by Marianne Collins.

Holotype of Helmetia expansa USNM 83952, dorsal view. Cross polarized light.

Losso, S. R., Caron, J. B., & Ortega-Hernández, J. (2025).

Ancient fossil sheds big light on evolution mystery: solving a 100-year arthropod mystery | Department of Organismic and Evolutionary Biology

A fundamental problem with creationism is that it depends on wilfully ignoring the vast and ever-growing body of contrary evidence. The intellectual dishonesty required to sustain this belief system makes its adherents the subject of ridicule—not just among scientists, but even among many fellow theists. Its prominent proponents, often elevated to near-prophetic status by their followers, are notorious for misrepresenting or outright lying about scientific findings. Unsurprisingly, they are treated with contempt by the scientific community.

One of the more blatantly counterfactual claims in the creationist repertoire is the assertion that there are no transitional fossils, and no evidence supporting the evolution of species from common ancestors. This denialism is essential to preserve belief in the spontaneous, magical creation of all species a few thousand years ago, without any ancestral lineage.

Accordingly, the creationist industry will need to deploy its usual strategies of misdirection and denial in response to a fascinating Cambrian stem arthropod, first discovered in 1918 in the Burgess Shale of Canada. Initially described from a single specimen, this enigmatic fossil has now been thoroughly reclassified thanks to the work of a team of Harvard researchers led by Dr Sarah Losso, a postdoctoral fellow in the Department of Organismic and Evolutionary Biology. Their analysis, based on 36 newly examined specimens, sheds significant light on early arthropod evolution.

Their findings are detailed in an open-access paper published in the Journal of Systematic Palaeontology, and summarised in a Harvard University news article.

Creationism Refuted - Something From Nothing - Let There Be Light!

Normalised ellipticity across the transverse plane for the Gaussian scenario.

Illustration of photon-photon scattering in the laboratory. Two green petawatt lasers beams collide at the focus with a third red beam to polarise the quantum vacuum. This allows a fourth blue laser beam to be generated, with a unique direction and colour, which conserves momentum and energy.

Credit: Zixin (Lily) Zhang

Oxford physicists recreate extreme quantum vacuum effects | University of Oxford Department of Physics

As Sam Harris once remarked, “When religions are right, they are right by accident.” His point highlights the lack of empirical grounding in religious claims, which are typically non-falsifiable and therefore beyond the scope of scientific validation.

Ironically, this may mean that the authors of Genesis were accidentally correct in one of their most iconic assertions: that the universe began with the creation of light (Genesis 1:3). While the biblical writers lacked any scientific understanding, modern physics now suggests that under extreme quantum conditions, something akin to this could indeed occur — light arising from an apparent vacuum.

This is an area where creationists normally tie themselves up in knots, claiming on the one hand that you can't get something out of nothing because it contravenes the laws of thermodynamics and on the other hand that a god made of nothing created the universe out of nothing with some magic words.

The truth, of course, is rather more rational and subject to scientific analysis and testing.

Researchers at the Department of Physics at the University of Oxford have successfully simulated a remarkable prediction of quantum electrodynamics: the spontaneous emergence of photons from empty space. Their work, published in Communications Physics, demonstrates how light can be generated from the quantum vacuum — a phenomenon that, until now, had only existed as a theoretical possibility.