Showing posts with label Creationism in Crisis. Show all posts
Showing posts with label Creationism in Crisis. Show all posts

Wednesday, 9 July 2025

Creationism Refuted - Tree Pollen Record - from 140,000 Years Before 'Creation Week'


Tree pollen reveals 150,000 years of monsoon history in Northern Australia – News

Droughts in Southeast Asia and increasingly devastating floods in Northern Australia are not random anomalies—they are predictable consequences of climate change, as revealed by a 150,000-year record of monsoon patterns preserved in tree pollen from sediment in Girraween Lagoon near Darwin. This record, meticulously analysed and correlated with evidence of past climate change and ocean currents, offers a stark warning about what lies ahead.

Not only does this research thoroughly dismantle the juvenile creationist fantasy that Earth is a mere 6,000 to 10,000 years old, it also flatly contradicts the myth of a global flood just a few thousand years ago—such a cataclysm would have obliterated the very sediment that preserved this climate history. Moreover, it challenges the simplistic notion that Earth was "finely tuned" for life, since the data show a planet subject to instability and extreme hardship, at times rendering regions locally uninhabitable due to global climatic shifts.

The study, conducted by researchers at James Cook University and Flinders University, demonstrates that shifts in Northern Australia's monsoon patterns coincide with Heinrich events—sudden surges of cold meltwater into the North Atlantic that weaken the Gulf Stream. As the Gulf Stream drives much of Western Europe’s climate by transporting warm water across the Atlantic, its disruption would have profound consequences for Europe as well.

Can you tell me more about these Heinrich events, please. Heinrich events are dramatic climatic episodes that occurred during the last glacial period, named after marine geologist Hartmut Heinrich who first identified them in the 1980s. These events represent sudden and massive discharges of icebergs into the North Atlantic Ocean, originating primarily from the Laurentide Ice Sheet in North America.

Key Features of Heinrich Events:
  1. Ice-Rafted Debris (IRD):
    Heinrich events are identified by layers of sediment in North Atlantic marine cores that contain ice-rafted debris—fragments of rock and other materials carried by icebergs and dropped onto the seafloor as the ice melted.
  2. Abrupt Cooling:
    The influx of cold, fresh meltwater into the North Atlantic during a Heinrich event disrupted thermohaline circulation (the so-called Atlantic Meridional Overturning Circulation, or AMOC), particularly the Gulf Stream. This led to abrupt regional cooling, especially in Europe and North America.
  3. Duration and Frequency:
    These events occurred roughly every 7,000–10,000 years during the last glacial cycle (~70,000 to 10,000 years ago), though the exact timing and spacing varied. Each event may have lasted for several hundred to a few thousand years.
  4. Global Impact:
    Although triggered by North Atlantic dynamics, Heinrich events had global repercussions. Evidence shows climate responses as far afield as the Indian monsoon, tropical Africa, and South America, where rainfall patterns shifted dramatically. The study you linked to adds Northern Australia to that list, showing that these events influenced monsoons far from their origin.
  5. Mechanism:
    The most widely accepted model suggests that internal ice-sheet instability or subglacial processes triggered massive iceberg calving events. These icebergs melted in the North Atlantic, introducing vast amounts of fresh water and lowering ocean salinity. This in turn weakened or shut down deep-water formation, a key component of the global climate system.



Summary:

Heinrich events are natural examples of abrupt climate change—rapid and severe disruptions to the climate system caused by shifts in ocean circulation. They provide a powerful lesson for today: large-scale climatic systems can change quickly and globally in response to disturbances, especially involving the ocean’s role in heat and moisture distribution.
The team's findings are now published in Quaternary Science Reviews, and are also explained in lay terms in a Flinders University blog post.
Tree pollen reveals 150,000 years of monsoon history in Northern Australia
Northern Australia’s annual monsoon season brings relief to drought-stricken lands and revitalises crops and livestock for farmers. But a study of 150,000 years of climate records shows that the monsoon is likely to intensify, triggering a higher risk of flooding while worsening the impact of droughts in East Asia.
Led by Professor Michael Bird, researchers at James Cook University and Flinders University have assessed sediments at Girraween Lagoon near Darwin, revealing a continuous record of monsoon rainfall patterns dating back beyond the last interglacial period.

This research published in the scientific journal Quaternary Science Reviews offers insight into how climate change could alter monsoon patterns across East Asia and Australia.

This is the longest terrestrial record ever produced at the southern end of the Indo-Australian monsoon system, which delivers vital rainfall to millions across the Southern Hemisphere. The record also has implications for the Northern Hemisphere where tens of millions in Asia rely on monsoons for food and their livelihoods.

Our study shows how the two monsoon systems are interrelated over thousands of years and reveals what causes them to change. Our analyses shows that that rainfall in northern Australia is closely tied to sea level changes, which shift the location of the northern coastline by up to 320 km.

These shifts strongly alter local rainfall, with wetter periods occurring when the coastline is closer to the Australian landmass and the oppose effect is prolonged drought in East Asia.

Intriguingly, the research also uncovered what we consider bursts of intense monsoon activity — some lasting less than 10,000 years. These bursts align with Heinrich events — abrupt pulses of freshwater into the North Atlantic from rapidly melting ice linked to the weakening of the Gulf Stream in the Atlantic Ocean.

Professor Michael I. Bird, first author
College of Science and Engineering
James Cook University
Cairns, Queensland, Australia.

These findings carry a warning from scientists because the Gulf Stream is already weakening due to climate change, and the study suggests this could lead to increased rainfall in northern Australia while contributing to droughts in parts of East Asia.

This isn’t just ancient history. It is a window into the rainfall patterns that are emerging today. Our data suggest that the weather trends we’re witnessing like the drying in China and wetting in northern Australia could accelerate if the Gulf Stream continues to weaken, so we need to be ready for that scenario.

It’s not surprising. Decreasing rainfall in parts of the east Asian summer monsoon region has been identified in rainfall records since the 1960s, while increasing rainfall has been evident in north-western Australia since the last century, accelerating since the 1950s. Our new data suggest that further weakening of the Gulf Stream could reinforce these trends even more in the future, with consequences for both regions.

We need to put this impact into context because this region extends from China through Southeast Asia, the maritime continent, and western Indo-Pacific warm pool on the Equator, to Australia. The region is home to almost a billion people and five terrestrial Biodiversity Hotspots.

Professor Corey J. A. Bradshaw, co-author.
Global Ecology | Partuyarta Ngadluku Wardli Kuu
College of Science and Engineering
Flinders University,
Adelaide, South Australia, Australia.

Publication:
Highlights
  • 150 kyr n-alkane δ2H and pollen record of monsoon strength from northern Australia.
  • Coastline position strongly influenced local hydroclimate.
  • Monsoon intensity broadly anti-phased with East Asian Summer Monsoon.
  • Short (∼2–10 kyr) periods of dramatically increased monsoon intensity also occur.
  • Short periods of increased monsoon intensity align with Heinrich events.

Abstract
Nearly two thirds of the world's population depend on monsoon rainfall, with monsoon failure and extreme precipitation affecting societies for millennia. Monsoon hydroclimate is predicted to change as the climate warms, albeit with uncertain regional trajectories. Multiple glacial-interglacial terrestrial records of east Asian monsoon variability exist, but there are no terrestrial records of equivalent length from the coupled Indo-Australian monsoon at its southern limit — Australia. We present a continuous 150,000-year lacustrine record of monsoon dynamics from the core monsoon region of northern Australia based on the proportion of dryland tree pollen in the total dryland pollen spectra and the hydrogen isotope composition of long chain n-alkanes. We show that rainfall at the site depends strongly on sea level, which changes proximity of the coast to the site by 320 km over the last glacial-interglacial cycle. Long-term trends in rainfall are broadly anti-phased with the east Asian monsoon modulated by coastal proximity. The record also contains multiple, short intervals (∼2 to < 10,000 years) of large changes in tree cover (from 5 to 95 % tree pollen over 3000 years in one instance). Changes in tree cover are frequently but not always, accompanied by synchronous large changes in the other hydroclimate proxies. While these wetter periods cannot be easily ascribed to orbitally induced changes in insolation or coastal proximity, they are correlated with most Heinrich events. This relationship implies that strong asymmetry in inter-hemispheric monsoon rainfall might be one outcome of the current weakening in the strength of the Atlantic meridional overturning circulation, through a reduction in oceanic heat transfer from the Southern to the Northern Hemisphere.

1. Introduction
The dominant feature of climate across most of the tropics and subtropics is a seasonal reversal of the prevailing winds across the Equator, resulting in a wetter summer season and a drier winter in each hemisphere. At an annual scale, the ‘global monsoon’, approximated hydrologically by the zone of maximum rainfall associated with the intertropical convergence zone, oscillates between the Northern and Southern Hemispheres (An et al., 2015; Wang et al., 2017). This oscillation is driven by the annual cycle of maximum insolation between each hemisphere (Deininger et al., 2020), leading to anti-phased summer rainy seasons in each (Eroglu et al., 2016; Deininger et al., 2020). Agriculture and ecosystems across the tropics and subtropics depend on monsoon rainfall (An et al., 2015), and so growing populations and climate change increase vulnerability to any change in monsoon dynamics (Zhang et al., 2018; Martinez-Villalobos and Neelin, 2023). Indeed, drought associated with monsoon failure, as well as monsoon-related flooding, have driven major demographic changes in prehistory (e.g., Cook et al., 2010) and the recent past (Li et al., 2011; Qian et al., 2012; Wang et al., 2015.1).

The monsoon system that affects the largest land area and human population is the east Asian summer monsoon north of the Equator, coupled by cross-equatorial airflow to the Indo-Australian summer monsoon south of the Equator (Li and Li, 2014) (Fig. 1). This region extends from China through Southeast Asia, the maritime continent and western Indo-Pacific warm pool on the Equator, to Australia. The region is home to almost a billion people and five terrestrial biodiversity hotspots (Myers et al., 2000).
Fig. 1. Location of Girraween Lagoon in monsoonal north Australia. Also shown are the Sunda and Sahul continental shelves, with areas landward exposed at times of lower sea level, and the major pathways for water and heat transport between the Pacific and Indian Oceans via the Indonesian throughflow. Approximate boundaries of the true and ‘pseudo’ monsoon domains and directions of wet season airflow are in yellow (Suppiah, 1992). Insert shows the approximate dominant flows of the east Asian summer monsoon (EASM) and the Indo-Australian summer monsoon (IASM). Additional locations mentioned in the text are: 1 and 2: speleothem stable isotope records from KNI-51 and Ballgown Cave, respectively (Denniston et al., 2017.1); 3: marine core geochemical record of runoff and dust flux (Zhang et al., 2020.1; Pei et al., 2021; Sarim et al., 2023.1); 4: speleothem isotope record from Flores (Scroxton et al., 2022); 5 and 6: Woods and Gregory ‘megalakes’, respectively (Bowler et al., 1998, 2001; Fitzsimmons et al., 2012.1). Base image data: Google © 2023 Maxar Technologies. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
The Indo-Australian summer monsoon represents the dominant source of rainfall in northern Australia, although atmospheric teleconnections to other sources of global interannual climate variability, particularly El Niño-Southern Oscillation, contribute to rainfall variability (Sharmila and Hendon, 2020.2; Heidemann et al., 2023.2; Gallagher et al., 2024). The Indo-Australian summer monsoon in northern Australia also exhibits its own internal dynamics, due in approximately equal measure to local oceanic (sea surface temperature, evaporation, and wind) and terrestrial (land cover, soil moisture, evaporation, and wind) influences on rainfall (Yu and Notaro, 2020.3; Sekizawa et al., 2021.1; Heidemann et al., 2023.2; Sekizawa et al., 2023.3). While the east Asian summer monsoon is dominant due to the large, high-altitude Asian landmass, the internal dynamics of the Indo-Australian summer monsoon can also drive variability in east Asian winter monsoon rainfall in southern China, suggesting close linkages (Yu and Notaro, 2020.3; Sekizawa et al., 2021.1; Heidemann et al., 2023.2; Sekizawa et al., 2023.3).

Terrestrial speleothem oxygen isotope and pollen records (e.g., Ma et al., 2023.4; Chen et al., 2023.5) spanning one or more glacial-interglacial cycles have demonstrated periods of enhanced/(reduced) east Asian summer monsoon rainfall at times of higher/(lower) Northern Hemisphere insolation and distinct, weak monsoon intervals, some of which are coincident with Heinrich events (Cheng et al., 2009, 2016.1). However, equivalent long terrestrial records from the southern end of the Indo-Australian summer monsoon in northern Australia are conspicuously absent.

Proxy records of terrestrial runoff have been derived from marine records off north-western Australia and are correlated with east Asian summer monsoon records (Pei et al., 2021; Zhang et al., 2020.1; Sarim et al., 2023.1) (Fig. 1). However, those records are potentially confounded by the adjacent wide continental shelf that introduces an effect of sea-level change at orbital timescales on the delivery of runoff-derived sediment to the core locations. The locations are also likely affected by the large changes in land-sea distribution in the maritime continent that modify heat and mass transfer through the Indonesian throughflow upstream of the core sites (Lee et al., 2019). On land, a discontinuous speleothem time series of oxygen isotope has been generated covering the last 40 kyr (1 kyr = 1000 years) from northern Western Australia (Denniston et al., 2017.1), a location that is under the influence of the ‘pseudo’ monsoon (Suppiah, 1992; Gallagher et al., 2024) where airflow originates in the eastern Indian Ocean, rather than from equatorial regions to the north (Fig. 1).

In the arid interior of Australia, sediments from the former Woods and Gregory ‘megalakes’ (now small, ephemeral bodies of water) show that large perennial water bodies existed, dominantly during periods in Marine Isotope Stage (MIS) 3 around ∼ 50 ka ago, MIS 5 around 100 ka ago, as well as earlier (Bowler et al., 1998, 2001; Veth et al., 2009.1; Fitzsimmons et al., 2012.1). These megalakes were fed by monsoon rain falling into south-draining catchments, with drainage divides at least 300 km south of the modern north Australian coast (Fig. 1). Kati Thandi-Lake Eyre in central Southern Australia receives water from the core monsoon area (and other regions), but it also contains a record of megalake periods through MIS 5 to ∼ 116 ka ago and from 65 to 45 ka ago (Cohen et al., 2022.1).

The existence of interior megalakes, orders of magnitude larger than today's, implies past periods of higher monsoon rainfall penetrating these arid interior catchments (Wyrwoll and Valdes, 2003). Debate on the drivers of megalake-filling events has centred on the relative importance of sea level, sea surface temperatures, and Northern Hemisphere ‘push’ versus Southern Hemisphere ‘pull’ of monsoonal rain into the continental interior, as well as the role of vegetation feedbacks in augmenting moisture transfer inland (Wyrwoll and Valdes, 2003; Liu et al., 2004; Miller et al., 2005; Pitman and Hesse, 2007; Marshall and Lynch, 2008; Wyrwoll et al., 2007.1, 2012.2).

Here we present multiple, absolute-dated proxy records of sedimentological, hydroclimatic, and vegetation change over the last 150 kyr from a sediment core obtained from the core monsoon region of northern Australia, the Girraween Lagoon (Fig. 1). This record enables an assessment of the timing of variation in monsoon strength in the Indo-Australian summer monsoon domain that can be compared with records of east Asian summer monsoon strength and tropical hydroclimate. Together, this enables an assessment of the drivers of variability in the Indo-Australian summer monsoon.
The detailed sedimentary record from the Girraween Lagoon in Northern Australia, which includes evidence of Heinrich events spanning the last 150,000 years, presents a serious challenge to young Earth creationist claims. These events, triggered by massive iceberg discharges into the North Atlantic and linked to widespread climatic shifts—including monsoon disruptions in Australia—can be correlated across multiple geological archives worldwide. This implies a stable, continuous, and datable sequence of climatic change that extends far beyond the 6,000 to 10,000 years typically allowed by biblical literalists.

Creationist claims of a recent, global, catastrophic flood—often tied to the story of Noah—are also incompatible with this evidence. A flood of such scale would have scoured landscapes, disrupted or homogenised sedimentary layers, and left a very different geological signal. Instead, the sediments in Girraween Lagoon preserve a finely layered and uninterrupted record of environmental conditions, including pollen and isotopic data, spanning well over 100,000 years. Such a record simply could not survive the violent upheaval proposed by a recent global deluge.

Furthermore, the evidence of repeated, severe climatic disruptions also undermines the notion that Earth was perfectly created and "finely tuned" for life. The Heinrich events were episodes of extreme instability, during which entire regions became uninhabitable or suffered ecological collapse. This shows Earth’s climate system as dynamic and often harsh—not the static, life-friendly world one might expect from an intelligent designer. In short, the geological and climatological evidence paints a picture of an ancient, evolving Earth shaped by natural processes—one that flatly contradicts creationist dogma.

Creationism Refuted - How Evolving COVID-19 Is Making Creationism Sick

Simplified SARS-CoV-2 Evolutionary Tree
AI Generated image (ChatGPT4o)

News, in The Conversation that the latest variant of the Sars-CoV-2 virus that causes COVID-19, XFG, could soon become the dominant variant worldwide, prompted me to ask ChatGPT to construct a family tree for the known variants of the virus, to illustrate the basic principles of evolution that creationists continue to deny.

Construct a family tree of known SARS-CoV-2 variants and explain how this illustrates evolution in progress. Explanation: Evolution in Progress

This tree diagram represents a simplified phylogenetic tree of SARS-CoV-2, showing how the virus has evolved since it first emerged in Wuhan in late 2019.

Sunday, 6 July 2025

Malevolent Designer News - How A Bacterium Is 'Intelligently Designed' To Spread Disease

Blacklegged tick, Ixodes scapularis

Bacteria hijack tick cell defenses to spread disease | WSU Insider

Here we have yet another example demonstrating that, if we apply Discovery Institute fellow William A. Dembski's criteria for proving intelligent design — namely the presence of complex specified genetic information — then we must conclude that creationism's supposed intelligent designer is, in fact, a malevolent force devising ever more sophisticated ways to inflict suffering on the world.

Once again, honest creationists are left with a stark dilemma: either complex specified information is indeed evidence of design, in which case the designer is malevolent, or it is not, in which case a central tenet of Intelligent Design creationism collapses. The dishonest ones, of course, will simply dismiss the evidence, likely misrepresent the science, and continue to bear false witness against scientists. In neither case should we expect creationists to admit that the theory of evolution fully accounts for the appearance of "malevolent" design, arising naturally without conscious intent or divine interference.

It’s a curious paradox that people who claim to worship the God of the Bible as an omnibenevolent, anthropophilic being are so often willing to see that deity cast in the role of a malevolent agent—so long as they can reject the theory of evolution. This strongly suggests that their opposition to evolution is not primarily theological, but political.

The latest example comes from the tick-borne pathogen Anaplasma, which causes anaplasmosis and contributes to Lyme disease. This bacterium hijacks the cellular machinery of ticks to ensure its own survival and transmission to new hosts, including humans. Although Dembski has famously avoided providing a rigorous, testable definition of "complex specified genetic information," any such definition would surely encompass genetic adaptations that promote survival and reproduction.

This discovery was made by researchers at the College of Veterinary Medicine, Washington State University (WSU). Their findings have just been published in Proceedings of the National Academy of Sciences (PNAS) and are explained in lay terms in WSU Insider, the university's online news outlet.

What information do you have on Anaplasma and the tick that transmits it? Anaplasma is a genus of bacteria that includes several species capable of causing disease in humans and animals. The most medically relevant species is Anaplasma phagocytophilum, which causes anaplasmosis—a tick-borne disease that affects both humans and various mammals.
  1. Overview of Anaplasma
    • Anaplasma are obligate intracellular bacteria in the family Anaplasmataceae.
    • They primarily infect white blood cells (especially neutrophils in the case of A. phagocytophilum).
    • Disease is often seasonal, peaking during the months of high tick activity (late spring to early autumn in temperate zones).

  2. Disease in Humans
    • Caused mainly by Anaplasma phagocytophilum.
    • Known as Human Granulocytic Anaplasmosis (HGA).
    • Symptoms include:
      • Fever, chills, headache
      • Muscle aches
      • Malaise
      • Occasionally gastrointestinal symptoms (nausea, vomiting)
      • In severe cases: respiratory failure, organ failure, neurological symptoms
    • Incubation period: ~5–14 days after a tick bite.
    • Treatment: Responds well to doxycycline, especially if started early.
    • If untreated, it can lead to complications, especially in the elderly or immunocompromised.

  3. Tick Vectors
    • The primary vector in the United States is the blacklegged tick (Ixodes scapularis), also called the deer tick.
    • In Europe, the main vector is the castor bean tick (Ixodes ricinus).
    • These are the same ticks that transmit Lyme disease (Borrelia burgdorferi) and Babesia (babesiosis), leading to frequent co-infections.

  4. Hosts and Reservoirs
    • Main animal reservoirs include:
      • White-tailed deer
      • Rodents
      • Small mammals
    • Ticks acquire the bacteria when feeding on an infected host and then transmit it during subsequent feedings.

  5. Biological Strategy of the Pathogen

    Recent research (such as the 2025 WSU referenced) shows that Anaplasmacan:
    • Hijack the tick's cellular defence mechanisms, particularly its oxidative stress response, allowing the bacteria to survive within the tick's gut.
    • Manipulate the cell death pathways of tick cells, suppressing apoptosis (programmed cell death) to extend the viability of the cells it infects.
    • Modify gene expression in the tick to enhance its own survival and transmission potential.

    These mechanisms qualify as highly sophisticated biological strategies—precisely the sort of adaptations that Intelligent Design proponents would struggle to explain without appealing to either special pleading or malevolent intent.

  6. Ecological and Public Health Impact
    • Geographic spread is increasing, partly due to climate change, which expands the habitat range of ticks.
    • Public health monitoring is challenged by co-infections and misdiagnosis (HGA is often confused with Lyme disease or viral infections).
    • Preventative strategies include tick checks, repellents, and public awareness campaigns.
Bacteria hijack tick cell defenses to spread disease
Washington State University researchers have discovered how the bacteria that cause anaplasmosis and Lyme disease hijack cellular processes in ticks to ensure their survival and spread to new hosts, including humans.
Based in the College of Veterinary Medicine, the team found that the bacteria can manipulate a protein known as ATF6, which helps cells detect and respond to infection, to support its own growth and survival inside the tick. The findings, published in the journal Proceedings of the National Academy of Sciences, could serve as a launching point for developing methods to eliminate the bacteria in ticks before they are transmitted to humans and other animals.

Most research has looked at how these bacteria interact with humans and animals and not how they survive and spread in ticks. What we have found could open the door to targeting these pathogens in ticks, before they are ever a threat to people.

Kaylee A. Vosbigian, lead author
Department of Veterinary Microbiology and Pathology
College of Veterinary Sciences
Washington State University, Pullman, WA, USA.

Vosbigian and her advisor, Dana Shaw, the corresponding author of the study and an associate professor in the Department of Veterinary Microbiology and Pathology, focused their research on Ixodes scapularis, also known as the black-legged tick, which is responsible for spreading both Anaplasma phagocytophilum and Borrelia burgdorferi, the causative agents of anaplasmosis and Lyme disease. Both diseases are becoming increasingly common and can cause serious illness in humans and animals.

The team discovered that when ATF6 is activated in tick cells, it triggers the production of stomatin, a protein that helps move cholesterol through cells as part of a normal cellular processes. The bacteria exploit this process against their tick hosts, using the cholesterol — which they need to grow and build their own cell membranes but cannot produce themselves — to support their own survival and success.

Stomatin plays a variety of roles in the cell, but one of its key functions is helping shuttle cholesterol to different areas. The bacteria take advantage of this, essentially stealing the cholesterol they need to survive.

Kaylee A. Vosbigian

When the researchers blocked the production of stomatin, restricting the availability of cholesterol, bacterial growth is significantly reduced. The researchers believe this shows targeting the ATF6-stomatin pathway could lead to new methods for interrupting the disease cycle in ticks before transmission occurs.

As part of the study, Vosbigian also developed a new research tool called ArthroQuest, a free, web-based platform hosted by WSU that allows scientists to search the genomes of ticks, mosquitoes, lice, sand flies, mites, fleas and other arthropod vectors for transcription factor binding sites — genetic switches like ATF6 that control gene activity.

There aren’t many tools out there for studying gene regulation in arthropods. Most are built for humans or model species like fruit flies, which are genetically very different from ticks.

Kaylee A. Vosbigian

Using ArthroQuest, the team found that ATF6-regulated control of stomatin appears to be prevalent in blood-feeding arthropods. Since the hijacking of cholesterol and other lipids is common among arthropod-borne pathogens, the researchers suspect many may also exploit ATF6.

We know many other vector-borne pathogens, like Borrelia burgdorferi and the malaria-causing parasite Plasmodium, rely on cholesterol and other lipids from their hosts. So, the fact that this ATF6-stomatin pathway exists in other arthropods could be relevant to a wide range of disease systems.

Assistant Professor Dana K. Shaw, corresponding author.
Department of Veterinary Microbiology and Pathology
College of Veterinary Sciences
Washington State University, Pullman, WA, USA.


Publication:
Significance
Infection dynamics for tick-borne pathogens like Anaplasma have primarily been studied in mammals. Comparatively less is known about tick–pathogen interactions. We found that Anaplasma activates the stress response receptor, ATF6, in ticks. Activated ATF6 functions as a transcriptional regulator. Using a custom script in R, we identified stomatin as an ATF6-regulated target that supports Anaplasma by modulating cholesterol trafficking. Our custom tool “ArthroQuest” revealed that the ATF6-regulated nature of stomatin is unique to arthropods. Given that lipid hijacking is common among arthropod-borne microbes, ATF6-mediated induction of stomatin may be exploited in many vector–pathogen relationships. In addition, our findings predict that there are many ATF6-regulated genes unique to ticks, highlighting that there is still much to be uncovered.

Abstract
How tick-borne pathogens interact with their hosts has been primarily studied in vertebrates where disease is observed. Comparatively less is known about pathogen interactions within the tick. Here, we report that Ixodes scapularis ticks infected with either Anaplasma phagocytophilum (causative agent of anaplasmosis) or Borrelia burgdorferi (causative agent of Lyme disease) show activation of the ATF6 branch of the unfolded protein response (UPR). Disabling ATF6 functionally restricts pathogen survival in ticks. When stimulated, ATF6 functions as a transcription factor, but is the least understood out of the three UPR pathways. To interrogate the Ixodes ATF6 transcriptional network, we developed a custom R script to query tick promoter sequences. This revealed stomatin as a potential gene target, which has roles in lipid homeostasis and vesical transport. Ixodes stomatin was experimentally validated as a bona fide ATF6-regulated gene through luciferase reporter assays, pharmacological activators, RNA interference transcriptional repression, and immunofluorescence microscopy. Silencing stomatin decreased A. phagocytophilum colonization in Ixodes and disrupted cholesterol dynamics in tick cells. Furthermore, blocking stomatin restricted cholesterol availability to the bacterium, thereby inhibiting growth and survival. Taken together, we have identified the Ixodes ATF6 pathway as a contributor to vector competence through Stomatin-regulated cholesterol homeostasis. Moreover, our custom, web-based transcription factor binding site search tool “ArthroQuest” revealed that the ATF6-regulated nature of stomatin is unique to blood-feeding arthropods. Collectively, these findings highlight the importance of studying fundamental processes in nonmodel organisms.

The North American deer tick, Ixodes scapularis, can transmit up to seven different pathogens that impact human and animal health including Anaplasma phagocytophilum (causative agent of anaplasmosis) and Borrelia burgdorferi (causative agent of Lyme disease) (1). The continuous rise in reported cases of tick-borne disease (210) underscores the need for novel intervention strategies. Although the intricacies of mammalian host–pathogen interactions have been well studied, comparatively little is known about tick–pathogen interactions.

Recently we have shown that A. phagocytophilum and B. burgdorferi activate the unfolded protein response (UPR) in ticks, which influences microbial colonization and persistence in the arthropod (11, 12). The UPR is a cellular response network that is initiated by three endoplasmic reticulum (ER) transmembrane receptors IRE1α, PERK, and ATF6. Each branch of the UPR initiates a signaling cascade and coordinates gene expression networks by activating specific transcription factors. We have shown that the IRE1α-TRAF2 pathway leads to microbe-restricting immune responses in arthropods by activating the NF-κB-like molecule, Relish (11). We have also demonstrated that stimulating PERK activates the antioxidant transcription factor, Nrf2, which facilitates pathogen persistence in ticks (12). Out of the three UPR receptors, ATF6 is the least understood (13). When activated, site-1 and site-2 proteases cleave the cytosolic portion of ATF6, which allows it to translocate to the nucleus and act as a transcriptional regulator (nATF6) (14). The role of ATF6 has never been explored in arthropod vectors.

Here, we demonstrate that Ixodes ATF6 is activated by tick-borne pathogens and supports A. phagocytophilum colonization in ticks. To determine how ATF6 impacts vector competence, we used protein modeling and a custom transcription factor binding site query to probe the ATF6 regulatory network in I. scapularis. Gene ontology (GO) and Reactome analyses identified Stomatin, a lipid homeostasis and vesical transport protein, as a potential gene regulated by ATF6 in ticks. Using pharmacological manipulations, RNA interference (RNAi), quantitative fluorescent assays, and immunofluorescence microscopy, we found that Stomatin supports pathogen colonization in ticks by facilitating cholesterol acquisition by the bacterium. These findings demonstrate that stomatin is induced during the arthropod-phase of the pathogen life cycle to enable survival and persistence in the vector.

Programs that predict transcription factor regulatory networks are generally restricted to model organisms, leaving out many arthropod vectors. We used our custom R script to develop a publicly available, web-based tool termed “ArthroQuest” that currently allows users to query 20 different arthropod vector genomes, in addition to Drosophila and humans. Queries with ArthroQuest revealed that the ATF6-regulated nature of stomatin appears to be unique to arthropods. Given that lipid hijacking and cholesterol incorporation is common in many arthropod-borne microbes (15), ATF6-mediated induction of stomatin may be a shared phenomenon among many vector–pathogen relationships that is exploited for the survival and persistence of transmissible pathogens.

This discovery poses a significant problem for proponents of Intelligent Design (ID) creationism because it challenges one of their core assertions: that complex specified information (CSI) within genetic material is a reliable indicator of an intelligent, purposeful designer. If we accept this premise, then we are compelled to ask why such intelligence would devote itself to crafting mechanisms that cause suffering, disease, and death—such as the ability of Anaplasma to hijack tick cell defences and ensure its own propagation at the expense of both ticks and mammalian hosts, including humans.

The usual ID response is to insist that their designer is benevolent — typically equated with the God of the Bible. But here, we are faced with a biological system so well-adapted to spreading infection that it must either be acknowledged as a product of evolutionary processes or attributed to a designer with malevolent intent. This is not a fringe example; it is one of many cases where nature reveals a level of intricate adaptation that ID advocates would normally cite as evidence for design, were it not so profoundly disturbing.

What this ultimately reveals is the theological inconsistency at the heart of ID creationism. The refusal to acknowledge the explanatory power of evolution, even when confronted with examples like Anaplasma, indicates that ID is not a scientific theory but a religious or ideological stance. The selective application of their own criteria — applauding "design" in butterflies but ignoring it in parasites — exposes the intellectual dishonesty behind the movement. Evolution, by contrast, provides a consistent and naturalistic framework that explains both the beautiful and the brutal features of the living world — without invoking a morally compromised designer.




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The Malevolent Designer: Why Nature's God is Not Good
This book presents the reader with multiple examples of why, even if we accept Creationism's putative intelligent designer, any such entity can only be regarded as malevolent, designing ever-more ingenious ways to make life difficult for living things, including humans, for no other reason than the sheer pleasure of doing so. This putative creator has also given other creatures much better things like immune systems, eyesight and ability to regenerate limbs that it could have given to all its creation, including humans, but chose not to. This book will leave creationists with the dilemma of explaining why evolution by natural selection is the only plausible explanation for so many nasty little parasites that doesn't leave their creator looking like an ingenious, sadistic, misanthropic, malevolence finding ever more ways to increase pain and suffering in the world, and not the omnibenevolent, maximally good god that Creationists of all Abrahamic religions believe created everything. As with a previous book by this author, "The Unintelligent Designer: Refuting the Intelligent Design Hoax", this book comprehensively refutes any notion of intelligent design by anything resembling a loving, intelligent and maximally good god. Such evil could not exist in a universe created by such a god. Evil exists, therefore a maximally good, all-knowing, all-loving god does not.

Illustrated by Catherine Webber-Hounslow.



The Unintelligent Designer: Refuting The Intelligent Design Hoax
ID is not a problem for science; rather science is a problem for ID. This book shows why. It exposes the fallacy of Intelligent Design by showing that, when examined in detail, biological systems are anything but intelligently designed. They show no signs of a plan and are quite ludicrously complex for whatever can be described as a purpose. The Intelligent Design movement relies on almost total ignorance of biological science and seemingly limitless credulity in its target marks. Its only real appeal appears to be to those who find science too difficult or too much trouble to learn yet want their opinions to be regarded as at least as important as those of scientists and experts in their fields.


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Thursday, 3 July 2025

Malevolent Design - How Having a Bigger Brain Made Humans More Vulnerable To Cancer Than Our Chimpanzee Cousins


A Single Genetic Mutation May Have Made Humans More Vulnerable to Cancer Than Chimpanzees | Newswise

According to creationists, humans are the designer’s special creation, and the Universe, Earth, and all life upon it were created solely for our benefit.

If that were the case, one might reasonably expect human design to be uniquely perfect—free from disease and physical defects. Yet, paradoxically, we are more prone to cancer than our closest evolutionary relatives, the other great apes. Recent research from the UC Davis Comprehensive Cancer Center suggests that this heightened cancer susceptibility may be linked to the very mutation that enabled us to develop our comparatively large brains.

It’s almost as though the 'designer' either deliberately endowed humans with a cancer-promoting mutation or failed to anticipate the consequences of the so-called "complex specified genetic information" (© William A. Dembski / Discovery Institute) introduced to facilitate brain growth—and then neglected to revise the design when the flaw became evident. But, of course, being omniscient, we have to assume, if we accept creationists dogma for the sake of argument, it knew full well what the consequences of its design would be and designed them with that consequence in mind.

The theory of evolution, of course, precisely predicts these kinds of suboptimal trade-offs and their consequences. As an undirected, uncaring process, evolution is concerned solely with reproductive success—not with long-term health, perfection, or ideal design.

Wednesday, 25 June 2025

Creationism Refuted - Now It's Frozen Wolf Cubs From 4,000 Years Before 'Creation Week'


14,000-year-old frozen wolf cubs recovered from permafrost at the Syalakh site, Northern Siberia
Famous Ice Age ‘puppies’ likely wolf cubs and not dogs, study shows - News and events, University of York

The mountain of evidence that creationists must ignore to maintain their belief that Earth is a mere 6,000–10,000 years old—because it says so in a book of Bronze Age mythology—just got a little bigger. A new analysis of the DNA of two frozen canid cubs found in Siberian permafrost confirms they were wolves, not early domesticated dogs as once speculated. The cubs, discovered near the village of Tumat in northern Siberia, are around 14,000 years old and genetically similar to modern wolves.

An analysis of DNA from their stomach contents reveals a mixed diet of meat and plant matter, consistent with the diets of contemporary wolves. Remarkably, some of the meat—specifically skin—came from a woolly rhinoceros, likely a calf, as adult rhinos would have been far too large for wolves to hunt. An earlier study had identified black fur in the cubs, prompting speculation that they might be early domesticated dogs, since melanism is commonly associated with dogs but not typically seen in wolves. However, further genomic analysis showed that these cubs belonged to a now-extinct wolf population that was not ancestral to domestic dogs. This suggests the black fur mutation may have been limited to that specific lineage, contributing nothing to the modern dog gene pool.

The puppies were found at the Syalakh site, the first in 2011 and the second in 2015. The site also contains mammoth bones showing signs of burning and processing by humans. This initially led to speculation that the cubs might have been tame or semi-domesticated wolves associated with early humans. However, that hypothesis can now be ruled out based on the genetic evidence. It is believed that the cubs died when a landslide trapped them in their den shortly after their final meal.

How the wolf cubs came to be fed on the skin of a woolly rhinoceros remains uncertain, but one plausible explanation is that it was scavenged from a kill made by humans.

Tuesday, 24 June 2025

Refuting Creationism - Biofluorescent fish 112 Million Years Before 'Creation Week'.

A tropical striped triplefin, Helcogramma striata.
© John Sparks and David Gruber

Creationists bunker - Evidence keep out! No Science Allowed!
Studies Reveal Fish Biofluorescence Dates Back 112 Million Years | AMNH

I sometimes imagine creationists hiding inside a bunker with no windows, completely cut off from the reality outside, where a torrential rainstorm is underway. From within their sealed refuge, they declare to themselves—and to the world outside—that there is no evidence of rain, simply because they can’t see any.

Their only source of information is a handful of picture books depicting a tropical paradise where it never rains, so they believe everything beyond their bunker must be warm and sunny—just as the picture books describe. Anyone who tells them otherwise, or tries to show them a different picture, must be lying to trick them.

How else can creationists be so insulated from the reality of the deluge of scientific evidence in the real world?

That slightly tortured analogy is by way of introducing another couple of scientific papers concerning the evolutionary divergence of the phenomenon of biofluorescence. Unlike bioluminescence—where light is produced by a physiological process using ATP and functions in total darkness—biofluorescence involves the absorption of ambient light, which is then re-emitted at a different frequency. Specialised proteins absorb this light energy, become unstable in their excited state, and return to their ground state by releasing photons—hence biofluorescence functions in low-light conditions.

Fish in particular, but also sea turtles and corals, use these glowing patterns as signals—for attracting mates, confusing predators, and more. According to two newly published papers by a team led by researchers at the American Museum of Natural History (AMNH), this phenomenon first emerged around 112 million years ago—once again, firmly within Earth’s long pre–'Creation Week' history. Since then, biofluorescence appears to have evolved independently up to 100 times, a clear indication of its adaptive benefits in dimly lit ocean environments.

Beyond the evidence for biological activity in a time creationists claim the Earth didn’t even exist, there's another uncomfortable detail for them: the researchers declare that to understand the pattern of bioluminescence in nature, “...we need to understand the underlying evolutionary story...” Not something a creationist, labouring under the delusion that biologists are abandoning the theory of evolution in favour of creationism, would want to read.

Their findings are published open access in Nature Communications and PLOS ONE.

Monday, 23 June 2025

Creationism Refuted - A Giant Salamander - 5 Million Years Before 'Creation Week'


Reconstruction of Dynamognathus robertsoni
Matthew Inabinett
ETSU fossil discovery reveals giant ancient salamander

Unlike most of the palaeontology unearthed by science—which is often tens or even hundreds of millions of years older than Earth, according to creationist dogma—this discovery dates to a mere 5 million years ago. But the problem for creationists isn’t one of degree; it’s one of absolutes. If anything is older than Earth according to their doctrine, then that doctrine is simply wrong. It’s as straightforward as that.

Likewise, if even a single transitional or ancestral form exists, then the creationist insistence that such forms don't exist is demonstrably false.

Curiously, despite failing to grasp that binary logic, creationists continue to convince themselves that if they can cast doubt on even the tiniest detail of evolutionary science—perhaps a small gap in the fossil record or a question about a single species—then the entire edifice of modern biology collapses and “God did it!” triumphs by default, all without the faintest scrap of supporting evidence.

With that essentially childish view of how evidence and reasoning work, it will likely make no difference to their claims that a team of researchers from the Gray Fossil Site & Museum and East Tennessee State University (ETSU) have discovered the fossil of a comparatively large salamander dating back around 5 million years. This find sheds light on the explosive diversification of salamanders in what is now Appalachia some 12 million years ago. Today, Tennessee is home to about 50 species of salamander—roughly one in eight of all living species.

Friday, 13 June 2025

Malevolent Designer - Creationism's Putative Desiger Designed A Way to Prevent Cancer Spreading - And Gave It To Sea Cucumbers!

A sugar compound found in sea cucumbers could hold the key to stopping the spread of cancer, according to a recent UM-led study published in Glycobiology.
Graphic by Stefanie Goodwiller
University Marketing and Communications

Sea Cucumbers Could Hold Key to Stopping Cancer Spread | Ole Miss

Imagine you're a designer, and you've created a species — humans — for whom you have a particular fondness. Only, something keeps going dreadfully wrong with your blueprint. A large number of them keep dying because their cells become cancerous when they fail to replicate properly, and these cancers then spread to other organs, which ultimately give up the ghost.

Now, you can’t quite work out why these cancers start. For some reason, you've included substances called glycans on the surfaces of cells, and — just to complicate things — you’ve made cancer cells produce an enzyme called Sulf-2, which alters these glycans to help the cancer spread. Your solution? A stroke of genius: create another enzyme that inhibits Sulf-2. And lo! It works.

So, who do you give this life-saving enzyme to?

If you're creationism’s supposedly super-intelligent designer, you don’t give it to your favourite species — the one made in your own image, no less. No, instead you bestow this miracle molecule upon… sea cucumbers. A species that, incidentally, doesn’t even have a problem with cancer.

This, if they actually understood the subject properly, is what Intelligent Design creationists consider compelling evidence of a supremely intelligent designer.

The discovery that sea cucumbers possess this enzyme was made by researchers at the University of Mississippi and Georgetown University in Washington, DC. Their findings are published in the journal Glycobiology and can be read here.

It’s also neatly summarised in a University of Mississippi news article:

Monday, 2 June 2025

Malevolent Design - The Sneaky Way TB Keeps On Making Us Sick

Credit: Md Ariful Islam


Study discovers DNA switch that controls TB growth – and could help unlock its antibiotic resistance secrets | University of Surrey
If you're an omniscient, omnipotent, malevolent designer of parasites — such as the bacterium that causes tuberculosis in humans — then you're hardly going to let a little thing like the immune system (which you supposedly also designed to protect them) or even the development of medical science and antibiotics spoil your fun in causing random suffering, are you? Naturally, you'd equip your creation with mechanisms to overcome these obstacles.

Within the framework of Intelligent Design creationism, that's precisely what this recent discovery should look like — at least to those creationists who don't simply ignore the obvious and pretend it isn't there. Scientists from the Universities of Surrey and Oxford have discovered that Mycobacterium tuberculosis uses a reversible process known as ADP-ribosylation to modify its DNA, controlling both replication and gene expression. This allows the bacterium to remain dormant for extended periods and reactivate when environmental threats, such as immune responses or antibiotics, have passed.

This presents a problem for creationists who insist on believing in a benevolent creator deity and simultaneously hold that features such as irreducible complexity and complex specified information are sure signs of intelligent design—claims promoted by Discovery Institute fellows Michael J. Behe and William A. Dembski. Since Mycobacterium tuberculosis displays these very characteristics, so either it was designed specifically to cause suffering, or those characteristics are not the reliable indicators of divine design that Behe and Dembski claim, and their entire argument collapses.

This discovery was recently published open access in The EMBO Journal, and further details are available in the University of Surrey press release:

Monday, 26 May 2025

Creationism Refuted - Exquisite Fossils From 226 Million Years Before 'Creation Week'

The Karoo Basin is a rich source of fossils for the Permian Period of life.
Image © WOLF AVNI/Shutterstock

Other life of this time included the lizard-like ancestors of tortoises, large amphibians that lurked like crocodiles just below the water surface, and forests dominated by a tree called Glossopteris with an understorey of spore-producing plants such as mosses, ferns and horsetails.
Photo: PEXELS
Exquisite new fossils from South Africa offer a glimpse into a thriving ecosystem 266 million years ago

In the realm of palaeontology, few discoveries are as illuminating as those that offer a window into ecosystems long vanished. A recent study published in The Conversation by palaeontologist Rosemary Prevec of Rhodes University, South Africa, unveils such a discovery: an exquisitely preserved fossil site in South Africa's Northern Cape province, dating back 266 million years to the middle Permian period. This site reveals a thriving ecosystem teeming with diverse plant life and a myriad of insect species, providing an unprecedented glimpse into pre-dinosaur terrestrial life.[1]

The significance of this find extends beyond its immediate scientific value; it directly challenges fundamental creationist assertions. By presenting concrete evidence of complex ecosystems existing millions of years before the advent of humans, it undermines the young-Earth creationist timeline that posits a 6,000 to 10,000-year-old Earth. The detailed stratigraphy and radiometric dating techniques employed corroborate the Earth's ancient history, aligning with the broader scientific consensus on geological and biological evolution.

Moreover, the discovery underscores the continuity and gradual progression of life forms, countering the notion of sudden creation. The intricate details preserved in these fossils—ranging from delicate insect wings to diverse plant structures—highlight the complexity and diversity of life well before the emergence of humans. Such findings reinforce the evolutionary narrative of life's development over hundreds of millions of years, offering tangible evidence against creationist models that reject evolutionary theory.

Rosemary Prevec's article in The Conversation is reprinted here under a Creative Commons licence, reformatted for stylistic consistency:
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