Malevolent Designer News - Is Creationism's Divine Malevolence Planning the Next Pandemic?

News - Bird flu is undergoing changes that could increase the risk of widespread human transmission - University of Nottingham

On top of a couple of recent papers showing creationist dogma to be false and that, if there were such a thing as an intelligent designer of living things, that designer can only be regarded as a malevolent monster, we have another paper which, if we believe creationist dogma, again shows their divine creator to be an obsessive, sadistic psychopath.

It is the news that scientists at Nottingham University, UK., and China have discovered how the variant of the H3N8 avian flu virus which is endemic in Chinese poultry farms, is mutating in a way which could make it more likely to cross the species barrier into humans and become the next pandemic.

What is the H3N8 Avian influenza virus and what threat does it pose to humanity?

H3N8 Avian influenza, also known as avian flu or bird flu, is a subtype of the influenza A virus that primarily affects birds, especially waterfowl and shorebirds. It is one of several subtypes of avian influenza viruses, each identified by specific combinations of surface proteins: hemagglutinin (H) and neuraminidase (N). In the case of H3N8, it refers to the third type of hemagglutinin (H3) and the eighth type of neuraminidase (N8) found on the virus's surface.

While H3N8 avian influenza primarily affects birds, it has the potential to pose a threat to humans under certain circumstances. Here are some key points to consider regarding its potential threat to humanity:

1. Zoonotic Transmission: Avian influenza viruses, including H3N8, are zoonotic, which means they can infect humans when they come into close contact with infected birds or contaminated environments. Most human cases of avian influenza have resulted from direct or indirect exposure to infected poultry.
2. Limited Human Infections: H3N8 avian influenza has not been as widely reported in human infections as some other avian influenza subtypes, such as H5N1 and H7N9. However, there have been occasional cases of H3N8 avian influenza infection in humans, often associated with direct contact with infected birds.
3. Potential for Adaptation: Avian influenza viruses have the ability to mutate and potentially adapt to human hosts. If a strain of H3N8 were to acquire the ability for efficient human-to-human transmission, it could lead to a more widespread outbreak or even a pandemic. This is a significant concern with avian influenza viruses in general.
4. Influenza Pandemic Preparedness: Due to the risk of avian influenza strains causing pandemics, public health organizations and governments worldwide monitor and study these viruses closely. Preparedness plans and strategies are in place to respond quickly to potential outbreaks, including the development of vaccines and antiviral medications.
5. Importance of Surveillance: Surveillance of avian influenza in both bird populations and humans is crucial to detect any changes in the virus's behavior or its potential to infect humans more easily. Timely identification and containment of outbreaks are essential to minimize the risk to public health.

In summary, H3N8 avian influenza is primarily a bird virus, but it can infect humans in rare cases. The main threat it poses to humanity lies in its potential to evolve and adapt to human-to-human transmission, potentially leading to a wider outbreak or pandemic. Vigilant surveillance, early detection, and preparedness are key components in mitigating this threat and preventing a significant public health crisis.

As explained in a Nottingham University news release, the evidence comes from an isolate of the H3N8 avian influenza virus (AIV) recovered from a human patient:

Researchers also say that the findings raise concerns of a potential epidemic or pandemic in the making and that concerted research is necessary to closely monitor such viruses in poultry and humans. The results, which have been published in Cell, report on the characterisation of a human isolate – from a human patient – of the H3N8 avian influenza virus (AIV). Using laboratory mice and ferrets as models for human infection, the study found that virus has undergone several adaptive changes to cause severe animal infections and making it transmissible by the airborne route between animals.

Human populations, even when vaccinated against human H3N2 virus, appear immunologically naïve to emerging mammalian-adapted H3N8 AIVs and could be vulnerable to infection at epidemic or pandemic proportion.

Professor Jinhua Liu, corresponding author
College of Veterinary Medicine, China Agricultural University, Beijing 100193, China

In humans, the avian H3N8 virus infection has been found to cause acute respiratory distress syndrome and can even be fatal. The virus is widespread in chicken flocks; however previously, the features of how it might be transmitted from animals to humans is poorly understood.

We demonstrate that an avian H3N8 virus isolated from a patient with severe pneumonia replicated efficiently in human bronchial and lung epithelial cells, was extremely harmful in its effects in laboratory mammalian hosts and could be passed on through respiratory droplets. Importantly, we discovered that the virus had acquired human receptor binding preference and amino acid substitution PB2-E627K, which are necessary for airborne transmission. Human populations, even when vaccinated against human H3N2 virus, appear immunologically naïve to emerging mammalian-adapted H3N8 AIVs and could be vulnerable to infection at epidemic or pandemic proportion.

Professor Kin-Chow Chang, co-author
School of Veterinary Medicine and Science
University of Nottingham, Loughborough, UK.

Acid resistance of influenza virus is also an important barrier for avian influenza virus to overcome to acquire the adaptability and transmissibility in new mammals or humans. The current novel H3N8 virus has not acquired the acid resistance yet. So, we should pay attention to the change on acid resistance of the novel H3N8 virus.

Professor Jinhua Liu

The study, titled ‘Airborne transmission of human-isolated avian H3N8 influenza virus between ferrets’ was a collaboration between the University of Nottingham, China Agricultural University in Beijing, the Chinese Academy of Sciences and the Chinese Center for Disease Control and Prevention.

In the abstract to their paper in cell, the main body of which is behind a paywall, the authors say:

Highlights

• Human-derived H3N8 viruses replicated efficiently in human respiratory epithelial cells
• Human-derived H3N8 viruses caused severe pathology in mice and ferrets
• One human H3N8 isolate acquired efficient respiratory droplet transmission in ferrets
• The PB2-E627K mutation is critical for H3N8 virus airborne transmission in ferrets

Summary

H3N8 avian influenza viruses (AIVs) in China caused two confirmed human infections in 2022, followed by a fatal case reported in 2023. H3N8 viruses are widespread in chicken flocks; however, the zoonotic features of H3N8 viruses are poorly understood. Here, we demonstrate that H3N8 viruses were able to infect and replicate efficiently in organotypic normal human bronchial epithelial (NHBE) cells and lung epithelial (Calu-3) cells. Human isolates of H3N8 virus were more virulent and caused severe pathology in mice and ferrets, relative to chicken isolates. Importantly, H3N8 virus isolated from a patient with severe pneumonia was transmissible between ferrets through respiratory droplets; it had acquired human-receptor-binding preference and amino acid substitution PB2-E627K necessary for airborne transmission. Human populations, even when vaccinated against human H3N2 virus, appear immunologically naive to emerging mammalian-adapted H3N8 AIVs and could be vulnerable to infection at epidemic or pandemic proportion.

Graphical abstract

Sun, Honglei; Li, Han; Tong, Qi; et al. (2023) Airborne transmission of human-isolated avian H3N8 influenza virus between ferrets
Cell; DOI: 10.1016/j.cell.2023.08.011

© 2023 Elsevier.
Reprinted under the terms of s60 of the Copyright, Designs and Patents Act 1988.

Given their cult's insistence that evolution can't account for genetic change over time, creationists must rule it out as the explanation for the ominous changes detected in this virus. Instead, they must credit them to their putative intelligent [sic] designer - seemingly oblivious of how this presents their god as a sadistic monster who designs parasites like these viruses for the sole purpose of making us sick.

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Thank you for sharing!

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