Monoclonal antibody-mediated neutralization of SARS-CoV-2:
The left panel illustrates the morphology of the SARS-CoV-2 virus and displaying the trimeric spike protein on its surface bound with antibodies. The right panel depicts the zoomed view of the trimeric spike protein (top view) in prefusion state bound with monoclonal antibodies. Each monomer of the spike protein shows the receptor binding domain (RBD) in green, orange and magenta, which contains a receptor binding motif in cyan on the top. Mutations emerged in the SARS-CoV-2 Omicron variants are shown in red. Here, the C309 (a parent of VIR-7831 or Sotrovimab) antibody is shown in blue, which is one of the antibodies in clinical use that is minimally impacted by the Omicron variant mutations.
Image Credit: Piyush Prakash, Anshumali Mittal, Vikash Verma, Arun Khatri (CC BY 4.0)
Creationist mode: 
In what may well prove to be a fruitless effort, Anshumali Mittal at the University of Pittsburgh, USA and colleagues have been trying to anticipate how Creationism's beloved pestilential mendacity is likely to modify its SARS-CoV-2 design to make it better at killing people and making others sick, despite the fact that many of them will now have a good degree of immunity, having either been vaccinated against it or acquired it naturally by surviving an earlier attack.
They have been doing so by working out what changes to the spike protein are most likely to enable the virus to evade the antibodies that our immune systems might throw at it in the future
Of course, as any worshiper of the evil genius behind the virus will tell you, it will never give up trying and will always manage to outwit medical science. It's almost exactly like it uses a random process that throws up an almost infinite range of mutations and combinations of mutations, and then something in the environment favours the ones which give most descendants, so even if they are the billion to one chance, the probability that they will arise and become predominant is virtually certain. Rather like repeatedly shuffling the pack and dealing four cards, then repeating until you get four of a kind. It might take days, but if you deal often enough, eventually you will get four of a kind.
Information released ahead of publication in PLOS Pathogens, the PLOS news release explains: