Killer T cells (red) and helper T cells (green) guarding tumour cells (light blue).
Image: Anniina Färkkilä
Creationist mode: 
In Finland in an average year, 550 women will be diagnosed with ovarian cancer and 320 of them will die from it. Now researchers at Helsinki University Hospital have discovered why ovarian cancers are proving to be unresponsive to the latest immunotherapies which are giving good results in the treatment of other cancer - ovarian cancers have been designed to be good at hiding from our immune systems.
They do it by tricking the immune system into actively protecting them! Brilliant, eh?
And this was the immune system the same intelligent [sic] designer supposedly gave us to protect us from its nastier little creations, such as viruses, bacteria, fungi and cancers that it designed to make us suffer and die from. Or so Creationists who argue that noting in nature happens by chance or by a mindless, undirected process such as evolution by natural selection, but is the deliberate creation of an intelligent [sic] designer, have to believe.
Creationist mode: 
So much for the childish superstitions and fairy tales that abound in fundamentalist religions.
The news release from Helsinki University explains the science:
The Helsinki team's research findings are published open access in the journal Nature Communications:With the help of this revolutionary imaging technology and advanced data analysis, we were able to study individual tumour cells, their functional properties and interactions with unprecedented precision.Cancer can only develop and progress when the tumour cells are able to hide from the body’s immune system. Cancer immunotherapies, which boost the body’s immune defence against cancer, have emerged as promising therapies in multiple tumor types. However, the effectiveness of immunotherapies against ovarian cancer has remained modest. This is mainly since the mechanisms how ovarian cancer cells hide from the immune system have been unknown.
Our findings will enable us to tailor precision immuno- and combination therapies that have the potential to even cure ovarian cancer in the future.
Associate professor Anniina Färkkilä, corresponding author
Research Program in Systems Oncology and Department of Obstetrics and Gynecology
Helsinki University Hospital, Helsinki, Finland
Now, researchers at the University of Helsinki have uncovered how tumour cells interact with the immune system in ovarian cancer. Utilising a novel imaging technology, the researchers characterized more than 110,000 individual cells from clinical ovarian cancer samples. The researchers investigated how the genetic characteristics of ovarian cancer the shape human immune system, and how tumour and immune cells communicate with each other.
[…]
By studying individual cells directly in the tissue, we demonstrated how cancer cells hide in different ways, depending on the specific gene mutation. We found that the body’s immune system is more effective against tumors with a mutation in BRCA1/2 genes. By contrast, tumours without such mutations have a connective tissue barrier prohibiting the interaction between the cancer and immune cells.Tumour genes trick the immune system
By increasing our understanding of how tumour genes trick the immune system, we will be able to develop more effective ways to activate the body’s own immune defences to kill the cancer cells.
Inga-Maria Launonen, BM., first author
Research Program in Systems Oncology
University of Helsinki, Helsinki, Finland
BRCA1/2 mutations occur in approximately 20% of poorly differentiated serous carcinomas, the most common form of ovarian cancer. The killer T-cells closely guarded the aggressive tumour cells particularly in tumours with BRCA1/2 mutations, which is why these patients had a markedly better prognosis.
Results will promote the tailoring of precision therapies
The results of the study confirm the significance of the interaction between tumour and immune cells in identifying new and more effective therapies as well as in choosing the right therapy for each patient.
Abstract
The majority of high-grade serous ovarian cancers (HGSCs) are deficient in homologous recombination (HR) DNA repair, most commonly due to mutations or hypermethylation of the BRCA1/2 genes. We aimed to discover how BRCA1/2 mutations shape the cellular phenotypes and spatial interactions of the tumor microenvironment. Using a highly multiplex immunofluorescence and image analysis we generate spatial proteomic data for 21 markers in 124,623 single cells from 112 tumor cores originating from 31 tumors with BRCA1/2 mutation (BRCA1/2mut), and from 13 tumors without alterations in HR genes. We identify a phenotypically distinct tumor microenvironment in the BRCA1/2mut tumors with evidence of increased immunosurveillance. Importantly, we report a prognostic role of a proliferative tumor-cell subpopulation, which associates with enhanced spatial tumor-immune interactions by CD8+ and CD4+ T-cells in the BRCA1/2mut tumors. The single-cell spatial landscapes indicate distinct patterns of spatial immunosurveillance with the potential to improve immunotherapeutic strategies and patient stratification in HGSC.
Launonen, I.-M.; Lyytikäinen, N.; Casado, J.; Anttila, E. A.; Szabó, A.; Haltia, U.-M.; Jacobson, C. A.; Lin, J. R.; Maliga, Z.; Howitt, B. E.; Strickland, K. C.; Santagata, S.; Elias, K.; D’Andrea, A. D.; Konstantinopoulos, P. A.; Sorger, P. K.; Färkkilä, A.
Single-cell tumor-immune microenvironment of BRCA1/2 mutated high-grade serous ovarian cancer
Nature Communications 13, 835 (2022). DOI: 10.1038/s41467-022-28389-3
Copyright: © 2022 The authors. Published by Springer Nature Ltd.
Open access
Reprinted under a Creative Commons Attribution 4.0 International license (CC BY 4.0)
Almost incredibly, but probably because they don't understand the science or their superstation, or both, well enough, Creationists continue to promote a view of their god as the creator of these monstrous evils, rather than accepting the scientific consensus that evolution by natural selection can easily account for them and explains why there appears to no morality involved in their creation. Just as they claim the appearance of design is proof of a designer, so they have to accept that the appearance of malevolence is proof of malevolent intent in that designer.
hmmm, one could almost say that ovarian cancer cells are god-duhs chosem 'people'
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