Princeton geneticists are rewriting the narrative of Neanderthals and other ancient humans
The picture of modern human (
Homo sapiens) interactions with Neanderthals (
H. neanderthalensis) has just become significantly richer. New evidence reveals not just a single episode of contact within the last 50,000 years, but several waves of interaction spanning much of our species’ 200,000-year history.
It was previously believed that after our last common ancestor with Neanderthals and Denisovans split into separate populations around 600,000 years ago, one lineage remained in Africa and eventually evolved into
H. sapiens by about 200,000 years ago. The other migrated into Eurasia and gradually diverged into Neanderthals in the west and Denisovans in the east, with limited contact between them. According to this model, modern humans left Africa around 60,000 years ago, encountered Neanderthals in Eurasia, and interbred with them shortly afterwards—about 40,000 to 50,000 years ago.
However, a new genomic analysis provides evidence for at least three distinct episodes of interbreeding. One occurred around 200,000 to 250,000 years ago—very early in the history of
H. sapiens. Another took place about 100,000 to 120,000 years ago, long before the final major migration out of Africa, and the last around 40,000 years ago, as previously believed.
These findings suggest that there may have been multiple early migrations of
H. sapiens into Eurasia, followed in some cases by return migrations back into Africa, before the final, successful dispersal around 60,000 years ago.
Some of the team’s evidence comes from detecting
H. sapiens DNA in the Neanderthal genome, so these ingressions could have come from earlier migrations that then failed, leaving only their DNA in the Neanderthal population.
There are still unresolve questions about which species migrated out of Africa, when, and whether some, such as
H. rhodesiensis, had a wide distribution across African and Eurasia with regional variants, so it is entirely possible that the earliest interactions with Neanderthals could have been between, say
H. rhodesiensis which brought Neanderthal genes back into Africa and then interbred with diverging
H. sapiens.
See the right-hand panel for an explanation of this so-called 'muddle in the middle'.
The study, led by researchers at Harvard University and Princeton University under the direction of Professor Joshua Akey of Princeton’s Lewis-Sigler Institute for Integrative Genomics, also supports the view that Neanderthals did not simply go extinct. Instead, their dwindling populations were gradually absorbed into expanding populations of modern humans.