Malevolent Design - How Sleeping Sickness Parasites Are 'Designed' to Evade Our Immune System

Trypanosoma brucei

Sleeping sickness

Discovery Illuminates How Sleeping Sickness Parasite Outsmarts Immune Response | Johns Hopkins | Bloomberg School of Public Health

Trypanosoma brucei is a blood-borne eukaryote parasite that should leave believers in an intelligent designer, open-mouthed in admiration for its inventive genius. Christian fundamentalist creationists of the white supremacist persuasion should also admire the racist that, through T. brucei, has managed to keep large parts of Africa technologically under-developed due to the difficult in maintaining herds of domestic animals where the vector of these parasites - the tsetse fly - is common.

As a vector, the tsetse fly is a triumph of malevolent design which I mentioned in my popular book, The Unintelligent Designer: Refuting the Intelligent Design Hoax, but it would have been all for nothing without the nasty little T. brucei to cause sleeping sickness in humans and the debilitating disease "nagana" in cattle.

What creationist admires of the divine malevolence they believe designs these things should now be marveling at is the sheer brilliance of the design by which it manages to evade the immune system, which they believe was created by the same designer god which now regards his design as a problem to be overcome oh parasites like T. brucei can continue making Africans and their cattle sick.

Refuting Creationism - First Steps to Abiogenesis

Diagram of the atmospheric evolution of Earth's ancient atmosphere estimated by this study

© Yoshida et al.

Research News - How Life Began on Earth: Modeling Earth's Ancient Atmosphere | Tohoku University Global Site

The fact that living organisms arose on Earth from inorganic sources rather than being made of nothing by magic, is an indisputable fact because there are living organisms on Earth and the chemicals they are composed of all exist on the planet in inorganic minerals and gases. 'Life' contains nothing that 'non-life' doesn't contain.

This much we know, but what we don't yet know and can probably never know with certainty, is precisely how and where that happen. In fact, we don't even know whether it did all start in the same place at the same time because the reason there are two different prokaryote cells - bacteria and archaea - could be because life arose on Earth not once but twice, by two different processes in two different places at two different times.

What we have though is lots of working hypotheses in the process of being validated.

What role would Earth's atmosphere have played in abiogenesis? Earth's early atmosphere was crucial in creating the right conditions for abiogenesis—the process by which life originated from non-living matter. While the exact composition of Earth’s primordial atmosphere is still debated, its unique conditions likely contributed in several essential ways:

1. Provision of Basic Building Blocks
   
   • Earth’s early atmosphere likely contained simple molecules like methane (CH₄), ammonia (NH₃), hydrogen (H₂), carbon dioxide (CO₂), nitrogen (N₂), and water vapor (H₂O). These molecules are rich in carbon, nitrogen, oxygen, and hydrogen—elements that are vital for organic compounds and, ultimately, for life.
   • When exposed to energy sources like ultraviolet (UV) radiation from the Sun or electrical discharges from lightning, these molecules could recombine into more complex organic molecules, such as amino acids and nucleotides, which are the building blocks of proteins and nucleic acids, respectively.
   
   
2. Facilitation of Prebiotic Chemistry
   
   • Experiments like the famous Miller-Urey experiment in 1953 showed that simple gases (methane, ammonia, hydrogen, and water vapor) in an atmosphere subjected to electrical sparks could produce amino acids. This suggests that Earth’s early atmosphere could have been instrumental in initiating chemical reactions that synthesized complex organic molecules.
   • Without a protective ozone layer, the early atmosphere allowed substantial UV radiation to penetrate the Earth’s surface, providing the energy necessary to drive these prebiotic reactions.
   
   
3. Supporting a Reducing Environment
   
   • The presence of reducing gases (such as methane and ammonia) would favor the formation of organic molecules because such conditions prevent the oxidation (and hence destruction) of organic compounds. Oxygen is highly reactive and can break down organic molecules, so the absence of free oxygen in the early atmosphere was likely a key factor that allowed these molecules to accumulate and react.
   • This reducing environment might have helped organic compounds to survive long enough to form stable, self-replicating systems.
   
   
4. Encouraging Geochemical Interactions
   
   • The interaction between the early atmosphere and the oceans, along with geothermal activity like volcanic eruptions and hydrothermal vents, provided a diverse range of chemical environments. In particular, hydrothermal vents may have supplied essential minerals and additional energy sources, further driving complex chemical reactions that are believed to be important in the formation of life.
   • The cycling of materials between the atmosphere and oceans would have contributed to creating localized "hotspots" for prebiotic reactions.
   
   
5. Protection and Concentration Mechanisms
   
   • The atmosphere also played a protective role by preventing the immediate dissipation of important compounds into space. It allowed the concentration of molecules and gases at Earth’s surface, increasing the chances of interactions among the essential precursors to life.
   • Early atmospheres may have helped regulate surface temperatures, preventing extreme fluctuations that would have been hostile to complex chemistry.
   
   
6. Encouraging Self-Organization and Membrane Formation
   
   • Interactions in the early atmosphere could have contributed to the formation of lipid molecules that could aggregate to form primitive cell-like structures or vesicles. These structures would eventually help in containing and protecting reactions necessary for early metabolic pathways.
   • These early "proto-cells" or vesicles would have been necessary to create a boundary for molecular interactions, which is a critical step toward the organization needed for cellular life.

In summary, Earth’s early atmosphere provided a chemically conducive, energetically rich environment that fostered the synthesis and concentration of organic molecules necessary for abiogenesis. This atmosphere also shielded these nascent molecules, allowing them to organize and evolve toward increasingly complex systems, eventually leading to the first living organisms.

One of which is the precise details of the atmosphere on the Early Earth, which is important because it would have had a major impact on the rest of the environment in which life arose. To gain a better understanding of that, a team from Tohoku University, Tokyo University and Hokkaido University, Japan, led by Tatsuya Yoshida have succeeded in modelling that atmosphere, as explained in a Tohoku University press release and published in the journal Astrobiology:

How Life Began on Earth: Modeling Earth's Ancient Atmosphere

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The key to unlocking the secrets of distant planets starts right here on Earth. Researchers at Tohoku University, the University of Tokyo, and Hokkaido University have developed a model considering various atmospheric chemical reactions to estimate how the atmosphere - and the first signs of life - evolved on Earth.

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Ancient Earth was nothing like our current home. It was a much more hostile place; rich in metallic iron with an atmosphere containing hydrogen and methane.

Shungo Koyama, co-author
Graduate School of Science
Tohoku University, Sendai, Japan.

These molecules contain an important clue to how life was initially formed. When exposed to solar ultraviolet (UV) radiation, they undergo a chemical reaction that produces organics (also known as the "building blocks of life"). Part of these organics were precursors to essential biomolecules, such as amino acids and nucleic acids. However, understanding the role of UV radiation is difficult. Firstly, this type of atmosphere is unstable and likely underwent rapid changes due to atmospheric chemical reactions. Secondly, when UV radiation efficiently breaks down water vapour in the atmosphere and forms oxidative molecules, the precise branching ratio and timescale has not been determined. In order to address these issues, a 1D photochemical model was created to make accurate predictions about what the atmosphere was like on Earth long ago.

The calculation reveals that most hydrogen was lost to space and that hydrocarbons like acetylene (produced from methane) shielded UV radiation. This inhibition of UV radiation significantly reduced the breakdown of water vapour and subsequent oxidation of methane, thus enhancing the production of organics. If the initial amount of methane was equivalent to that of the amount of carbon found on the present-day Earth's surface, organic layers several hundred metres thick could have formed.

There may have been an accumulation of organics that created what was like an enriched soup of important building blocks. That could have been the source from which living things first emerged on Earth.

Tatsuya Yoshida, lead author
Graduate School of Science
Tohoku University, Sendai, Japan.

The model suggests that the atmosphere on ancient Earth was strikingly similar to what we see on current day neighbouring planets: Venus and Mars. However, despite their proximity, Earth evolved into a completely different environment. Researchers are trying to understand what makes Earth so special. As such, this model allows us to deepen our understanding of whether atmospheric evolution and the origin of life on Earth are unique or share common patterns with other planetary systems.

These findings were published in the journal Astrobiology on October 22, 2024.

Publication Details:

Tatsuya Yoshida, Shungo Koyama, Yuki Nakamura, Naoki Terada and Kiyoshi Kuramoto
Self-Shielding Enhanced Organics Synthesis in an Early Reduced Earth's Atmosphere Astrobiology DOI: 10.1089/ast.2024.0048

Abstract
Earth is expected to have acquired a reduced proto-atmosphere enriched in H₂ and CH₄ through the accretion of building blocks that contain metallic Fe and/or the gravitational trapping of surrounding nebula gas. Such an early, wet, reduced atmosphere that covers a proto-ocean would then ultimately evolve toward oxidized chemical compositions through photochemical processes that involve reactions with H₂O-derived oxidant radicals and the selective escape of hydrogen to space. During this time, atmospheric CH₄ could be photochemically reprocessed to generate not only C-bearing oxides but also organics. However, the branching ratio between organic matter formation and oxidation remains unknown despite its significance on the abiotic chemical evolution of early Earth. Here, we show via numerical analyses that UV absorptions by gaseous hydrocarbons such as C₂H₂ and C₃H₄ significantly suppress H₂O photolysis and subsequent CH₄ oxidation during the photochemical evolution of a wet proto-atmosphere enriched in H₂ and CH₄. As a result, nearly half of the initial CH₄ converted to heavier organics along with the deposition of prebiotically essential molecules such as HCN and H₂CO on the surface of a primordial ocean for a geological timescale order of 10–100 Myr. Our results suggest that the accumulation of organics and prebiotically important molecules in the proto-ocean could produce a soup enriched in various organics, which might have eventually led to the emergence of living organisms.

Yoshida, Tatsuya; Koyama, Shungo; Nakamura, Yuki; Terada, Naoki; Kuramoto, Kiyoshi
Self-Shielding Enhanced Organics Synthesis in an Early Reduced Earth’s Atmosphere Journal of Astrobiology (2024) DOI: 10.1089/ast.2024.0048

© 2024 Mary Ann Liebert, Inc.
Reprinted under the terms of s60 of the Copyright, Designs and Patents Act 1988.

So, by the action if UV radiation from the sun on the inorganic molecules in Earth's early atmosphere for a period of some 10-100 million years, the oceans could have accumulated the basic building blocks for organic organisms to get started, and all th result of chemistry and physics with no magic gods involved at any point.

And, as usual with scientific discoveries, the truth is shown to have little resemblance to the origin myths the parochial Bronze Age pastoralists made up to fill the yawning chasm in their knowledge and understanding of the world around them, with their belief that Earth had only existed for a few thousand years, so were blissfully ignorant of the 99.9975% of its history that occurred before then.

Refuting Creationism - What Happened When a Massive Metor Hit Earth 3 billion Years Before 'Creation Week'

Impression of a massive impact 3.26 billion years ago

AI-generated (ChatGPT4o)

What happened when giant S2 meteor hit Earth 3 billion years ago?— Harvard Gazette

Barberton Greenstone belt of South Africa.

Photo: Nadja Drabon

Creationists love to tell us how their putative intelligent designer designed an entire Universe with countless trillions of stars many with planetary systems, and made a special one called Earth which is perfectly designed for them to live on.

The problem with that comforting lie is that it isn't borne out by the disturbing truth. Not only is Earth far from perfect for their (human) life over most of its area, being inaccessible and hostile without special human-made technology, but it has been, and probably will be again, subject to almost unimaginable, catastrophic events in its past, such as plate tectonics causing changes in ocean currents which caused climate change so drastic the Earth literally froze over. There have equally been times when the polar icecaps melted flooding coastal areas where many of our modern major cities and ports are located.

Refuting Creationism - Walking With Dinosaurs 70-75 Million Years Before 'Creation Week'

Artist's depiction of H. piceanus in a Late Cretaceous swamp.

Illustration by Brian Engh
LivingRelicProductions.com

Paleontologists discover Colorado ‘swamp dweller’ that lived alongside dinosaurs | CU Boulder Today | University of Colorado Boulder

Paleontologists dig for fossils in northwestern Colorado.

Credit: John and ReBecca Foster.

AI-Generated illustration of life in a Cretaceous swamp near the Western Inland Seaway

ChatGPT4o

For some reason creationists have a fixation with dinosaurs, probably because, deep down, they know their existence refutes the biblical nonsense of an Earth that's only 6-10,000 years old. After all, there is nothing quite like a 75 million-year-old fossil of a living creature for falsifying the idea that the Universe, Earth and life on it were all created in a single week, just a few thousand years ago.

So, their cult leaders are forever scraping around trying to find evidence that human beings and dinosaurs lived together and even that Jesus would have been familiar with T. rex or Diplodocus and was probably used to pterosaurs flying overhead. But of course, there is none - which was never a reason for a creationist to abandon a delusion.

What there is, however, is evidence that dinosaurs were around until about 66 million years ago then promptly went extinct to be replaced by birds and mammals as the dominant terrestrial life forms.

And now we have evidence of an early mammal living amongst dinosaurs in what if now Colorado, USA. Sadly, there is no evidence that the early mammal resembled Jesus or any other humans for that matter; it was more like a muskrat.

Refuting Creationism - Producing 'Life' in The Laboratory

Biological systems serve as examples for the simplified artificial systems used to create synthetic cells.

Beeld Willy Arisky via Pexels

Creating a simplified form of life | News articles | University of Groningen

One of the more amusing questions creationists keep asking is how did 'life' come from non-life? Or more dogmatically, they claim 'life' from 'non-life' is impossible.

They then scuttle off to hide when asked to define, 'life' and state how it can be measured to assess whether something like a rock, a bacterium or a bowl of chicken soup has any life in it. It causes the same tactic of avoidance when asked to explain how dead food becomes living tissues during the process of digestion and metabolism, if that's impossible?

The problem is creationists have been brainwashed into thinking that 'life' is something magical; some special force that turns inorganic chemicals into 'living' structures. In fact, 'life' is a process involving atoms and molecules doing their chemistry according to the fundamental laws of chemistry and physics. And the function of the process is to manage entropy - the tendency of a system to become disordered - using the energy in nutrients.

And rather than 'life' being something magical which is magically inserted into a developing embryo at some unspecified day of its development from a zygote to a free-living organism, it's actually a continuation of the life processes of the egg and sperm that united to form the zygote. There never is a 'new life', just a continuation of the parent's entropy management process.

Refuting Creationism - Humans Were Butchering Elephants In India 300-400,000 Years Before 'Creation Week'

The elephant skull being excavated from the quarry in Kashmir in 2000.

Photo: Advait Jukar

Rare fossils of extinct elephant document the earliest known instance of butchery in India – Research News

Having taken a short break from writing blog posts to work on a new book, I'm now taking a short break from writing a book to catch up on an accumulation of papers that refute creationism, not intentionally (few serious working scientists bother to do that nowadays) but quite incidentally by simply revealing facts that are entirely inconsistent with creationist dogmas.

This news release, for example, exposes the fact that there were humans butchering elephants in India between 300,000 and 400,000 years ago in that 99.9975% of Earth's history that happened before creationists believe there was even an Earth for people and elephants to live on.

The evidence is the cut marks on the remains of a three extinct giant elephants, Palaeoloxodon turkmenicus, which died near a river at what is now Pampore in the Kashmir Valley. Soon after they died, they were covered in sediment and buried along with 87 stone tools that had been used to butcher them along with the bone flakes that show the bones were struck in exactly the right way to extract the marrow. The butchers clearly knew what they were doing.

Refuting Creationism - Seven New Frogs In Madagascar And How They Evolved

Boophis janewayae

Photo by M. Vences
CC BY-SA 4.0

Boophis marojezensis. Now know to be 8 different species.

By Franco Andreone - see authorization - http://calphotos.berkeley.edu, CC BY-SA 2.5, Link

Seven New Frog Species Discovered in Madagascar: Sounds Like Something from Star Trek – University of Copenhagen

An international research team have discovered seven new species of tree frog in Madagascar, all members of the Boophis genus, previously thought to be a single species. They are characterized by their distinctive sounds. Their high-pitched whistles are unlike the sounds normally associated with frogs and sounding more like something from science fiction prompted their discoverers to give them all names based on Star Trek captains: Boophis archeri (Archer), Boophis burnhamae (Burnham), Boophis janewayae (Janeway), Boophis kirki (Kirk), Boophis picardi (Picard), Boophis pikei (Pike), Boophis siskoi (Sisko).

The basis for the revised taxonomy is two-fold - genetic and bioacoustic. Although there are all morphologically similar, differing mainly in size, the genetic evidence shows they have diverged into genetically isolated populations and the acoustic evidence shows how genetic separation is maintained by a prezygotic barrier to hybridization. The high pitch of their calls is believed to make them audible above the sound of running water in their normal environment.

Speciation in Progress - A Genetically Isolated Population of Harbor Seals

A harbor seal, Phoca vitulina in Iliamna Lake, Alaska.

Photo credit: Jason Ching

This article is best read on a laptop, desktop or tablet

Alaska’s Iliamna Lake harbor seals commonly move more than 200 kilometers. Researchers hypothesized that they move regularly between freshwater and marine habitats.

Photo credit: David Withrow, NOAA Fisheries.

FAU | Iliamna Lake Harbor Seals Genetically Isolated from Pacific Ocean

The Iliamna Lake harbor seals are one of only a handful of seals that live wholly in fresh water, the best-known example of which is the Lake Baikal seal in Russian Central Asian.

The Alaskan seals have probably been isolated for thousands of years having entered the lake when it was connected to the Pacific before it became isolated from the ocean. The seals have lived there in isolation ever since. These are the classic conditions for allopatric speciation to occur as the founder effect, genetic drift and local environmental selectors cause them to diverge genetically from their parent population in the Pacific.

Malevolent Designer News - Stand By For The Next Move In The Mpox Arms Race

Colorized transmission electron micrograph of mpox virus particles (light green) found within VERO E6 cells (teal).

NIAID Integrated Research Facility
Fort Detrick, Maryland.

Mpox virus particles

Mpox Vaccine Is Safe and Generates a Robust Antibody Response in Adolescents | NIAID: National Institute of Allergy and Infectious Diseases

As Medical science announces success in the search for a vaccine against the mpox virus currently spreading misery and suffering around the globe, we can be as sure as can be that creationism’s divine malevolence is working on a variant with an inbuilt way to evade the antibodies the vaccine produces, in just the same way it did with COVID-19 - if you believe a magic designer is behind these things, the way intelligent [sic] design creationists do.

Christian Hypocrisy News - SBC Pastor And Former Seminary Professor Lied To The FBI To Protect Sexual Predators

Pastor Matt Queen preaching at Friendly Avenue Baptist Church
Greensboro, N.C., May 5, 2024

Pastor Matt Queen, preaching at Southwestern Baptist Theological Seminary, March 2023

Matt Queen, SBC pastor and former seminary professor, pleads guilty to lying to FBI

The fundamental principles of Christianity are supposedly the rules allegedly handed down to Moses by God in the form of the Ten Commandments, although there is some confusion over which ten commandments is the because the only set of ten rules called The Ten Commandments in the Bible are all about what food to eat when, what to sacrifice when, etc., (Exodus 34:17-26) and nothing to do with human interactions - the basis of society.

The rules allegedly give to Moses in the form of writing on two 'tablets of stone' are what are normally referred to as The Ten Commandments, although there are two different versions (Exodus 20:2-17 and Deuteronomy 5:7-21), differing especially over the reason for 'keeping the sabbath holy'. Apparently, God changed his mind on that point.

But incorporated in these latter commandments is the Golden Rule almost certainly plagiarized from neighboring cultures because no culture could succeed without a form of it - Treat others the way you would like them to treat you. In other words, do something that fundamentalists seem to find baffling - use your innate empathy ability to work out how to behave in any given situation.

that rule obviously covers killing, stealing, etc., so renders them redundant in any list of rules of civilised behaviour, so perhaps the second most important rule is 'no lying', or, in biblical terms, no bearing false witness against others and no trying to fool people into believing thongs you know aren't true.

You could argue of course that lying to someone, or to paraphrase Mark Twain's, "trying to fool someone into believing something that aint so", is really covered by the Golden Rules because you wouldn't want someone to trick you into believing some thig that aint so, so you shouldn’t try to trick them.

So, given the readiness of Christians to lie for their faith, it is very clear that scant regard is being paid to the rules they would like to impose on the rest of us if ever they regained the power over us that they once had. In fact, piety is used as an excuse to self-licence an exemption from the rules they insist other should live by, demonstrating yet again the truism that religions provide excuses for people who need excuses. They're not only trying to fool us with false witnessing but they're doing something to us that they wouldn't want us to do to them. In other words, they're being something that Jesus allegedly forbade them from being - hypocrites. (Matthew 15: 7-8)

It should come as no surprise than that a leading Southern Baptist has been exposed as a lying hypocrite. Indeed, its's almost as though he believes there is no omnipotent god who will one day judge him, with special scrutiny on how faithfully he's complied with the God-given rules, or not. This particular hypocritepious Christian is none other than a Southern Baptist Convention pastor and seminary professor, Matt Queen, who has just admitted lying under oath to the FBI and creating false documents in order to deceive those investigating allegations of sexual abuse.

Refuting Creationism - The Japanese People Didn't Notice Noah's Genocidal Flood!

Representation of Jomo-period life in Japan in the shadow of Mount Fuji

AI-generated (ChatGPT4o)

Human remains from the Yayoi period, approximately 2,300 years ago, from which DNA was extracted.

Map of Japan showing Sakhalin (far north) and the Kuril and Ryukyu Islands

Google Map

Traces of ancient immigration patterns to Japan found in 2000-year-old genome | SCHOOL OF SCIENCE THE UNIVERSITY OF TOKYO

Being parochial Bronze Age pastoralists who knew about nothing and nowhere that was more than a day or two's walk from their hill pastures in Canaan, those who made up the Hebrew creation myths could not possibly have been aware that there were other cultures in far-away places like China, Korea and Japan, which had ancient histories going way back before the myth-makers thought Earth was created, and which were unscathed by an global flood at the time in which they set that tale.

Had they been aware of them, they could have made up slightly more plausible myths with a more realistic timeline, instead of requiring their believers to try to compress everything that's happened in the entire 14-billion-year-old Universe into 10,000 years.

But how could they have done so when they had no-one to teach them the real history of the planet and the people living on it? All they had was their own limited imagination and a handful if inherited myths from neighbouring culture, like Egypt and Sumeria, for theirs was a backward, illiterate culture from the fearful infancy of our species, dependent on oral traditions and superstitions.

How could they possibly have known, for example, that a population of humans had been more or less isolated for about 6,500 years, ending at about the time the myth-makers believed Earth was made out of nothing by magic, complete with a dome over it to cover the small, flat place they called home? They would have known nothing about immigration from China or from the Korean Peninsula into the Japanese archipelago that brought this period of isolation to an end and probably resulted in the present-day population of Japan.

So, of course, they saw nothing wrong with inventing a tale about a genocidal flood killing everyone apart from 8 related survivors, or of building a tower to reach above the dome or about a panicking god making them all speak different languages so they couldn't work in cooperative groups any more, and yet, if their tale is to be believed, the descendants of those few survivors, all speaking different languages, migrated to places like China, Korea and Japan where they all adopted the local language and writing that had been used for several thousand years, forgot all about Noah and his flood and invented new gods and religions, whereas the myth-makers of Canaan remembered it all word-perfect in every detail...

So, how do we know the record they left was wrong?

Unintelligent Design - The Blunder That Causes Cancers

Ludwig Cancer Research

It has often been a theme of my blog posts how, if we regard cells as the result of conscious (I won't use the term 'intelligent' as that's singularly inappropriate, as we shall see) design then the picture quickly emerges of a bungling incompetent, cobbling together Heath-Robinson solutions to problems of its own incompetent making and lack of foresight.

The entire system of epigenetics, for example, is only necessary in a multicellular organism with its cell specialisation because specialised cells only need a small subset of the entire genome, yet, because cells replicate using exactly the same process that single-celled organisms use, where the entire genome needs to be replicated in every daughter cell, the cells of multicellular organisms such as humans each receive the entire species genome. So, most of it needs to be turned off.

This is where the epigenetic system comes in where methyl groups are attached to key bases in the DNA which prevents that section being transcribed into RNA, effectively switching the gene off. There are other components to the epigenetic system, but that is the pertinent component as far as this particular blunder is concerned.

The problem starts when a methyl group is attached to a cytosine base (C in the CGTA genetic code) which is next to a guanine(G) base.

Unintelligent Design Or Sheer Malevolence? - Defective Sperm Puts Mother And Baby At Risk

AI-generated graphic illustrating preeclampsia
(with AI spelling)

ChatGPT4o

Defective sperm doubles the risk of preeclampsia | Lund University

Christian superstition insists that every person conceived is a creation of their omniscient, omnipotent god who knows and has always known, exactly who is going to be born and has an oven-ready plan for their entire existence. Each baby conceived was exactly as the Christian god intended, down to the last detail of the DNA Exactly which sperm fertilizes which egg when, is part of the god's omniscient, perfect plan.

Leaving aside the absurdity of throwing millions of sperms at a single egg to produce that conception, when only a predetermined one was going to be the winner in order to produce the predetermined genome, when a single sperm would have been just as effective, we are left with the disturbing idea that any and all genetic defects were the intended outcome of that conception; the intention of a supposedly omnibenevolent god.

Now, it might, in fact it definitely is possible for a Christian to imagine some ultimate good will come from a child with a genetic defect, but what if a defect in the sperm causes harm not just to the baby, but to the mother? Are we to conclude that a mother whose life is put at risk by a defective sperm from her partner was the intended victim of an 'all-loving' god? What possible good can come from a mother's (and almost invariably her baby's) life being in danger from something beyond her control? What possible good can come from preeclampsia?

Refuting Creationism - How A Beetle Evolved To Eat Toxic Plants

Red milkweed beetle, Tetraopes tetrophthalmus

CC BY 2.5, Link

Red milkweed beetle, Tetraopes tetrophthalmus

Red milkweed beetle genome sequence offers plant-insect co-evolutionary insights

We are continually being assurd by gullible cretionists that the Theory of Evolution (TOE) is 'a theory in crisis' becase a growing body of biologisdts have abandonned it in favour of the creationists superstition of intelligent [sic] design.

This has been a creationist fantasy for at least the last 50 years since when it is supposedly about to happen, any day now, real soon (a bit like The Second Coming of Christ - something which, despite regular announcements that it will happen next Wednesday at noon, never happens - but its gunna, you see!)

However, when we read the scientific publications of these biologists who are allegedly abandoning the TOE, we see no signs whatever of any abandonment; quite the opposite. We see the TOE as firmly embedded in biological science as the Laws of Thermodynamics and the Theory of Gravity are embedded in physics, Atomic Theory is embedded in chemistry and Germ Theory is embedded in epidemiology. It forms the bedrock of the science, without which very little makes any sense.

For example, when a bunch of entomologists wanted to understand how a species of herbivorous beetle can eat a toxic plant, they compared it genomically with a related species that doesn't eat the toxic plant to see how the ability to proccess the toxins evolved.

Of course, being scientists, they reject the idea that the beetle was magically created that way by an unproven supernatural entity because none of that can be falsified and the existence of such an entity can't be established, so there is no logical reason to include one in any answer. The fact that their mummies and daddies might have believed in it is irrelevent to their science, because belief doesn't create facts.

Malevolent Design - How Chlamydia Is 'Designed' to Cause Maximum Sufferring.

Chlamydia pneumoniae

AI-generated image (ChatGPT4o)

Schematic representation of how a C. pneumoniae cell infects a human cell. The bacterium injects the protein SemD (green) into the cell, which activates the cell protein N-WASP, which in turn initiates vesicle formation.

Credit: HHU/Fabienne Kocher.

Universität Düsseldorf: Original or copy: How Chlamydia manipulate the host cell

The problem of parasites for creationists is one that, despite the best efforts of apologists like Michael J Behe of the Deception Institute, just won't go away.

Sadly, Behe shot himself in the foot with his original claim to have proven 'intelligent [sic] design in living organisms with his choice of the bacterial flagellum in E. coli, where he persuaded his willing audience that these nasty little pathogens had been intelligently designed - and by unspoken assumption, designed by the locally-popular god.

Now creationists wave his 'proof' of design as evidence for their creator god because only their god is capable of creating living organisms.

But, with characteristic double-think, creationists also argue that their god is omnibenevolent, so something else must have created parasites like E. coli, and, courtesy again of Michael J. Behe, they cite 'Sin' causing 'genetic entropy' and the absurd idea of 'devolution' this supposedly causes, as the cause of parasites and pathogens (but not the bacterial flagellum, obviously!).

The problem with that notion is that they need to do their double-think trick one more time and believe that a trait with improves a pathogens ability to live and reproduce in its host makes it somehow less perfect that one without that trait. So, in the creationist's world, an improvement is a move away from perfection!

But, with a cult that appears to believe learning is a move away from the 'perfection' of pristine ignorance (from whence comes expertise in all aspects of science), that's probably not too difficult a feat of mental gymnastics for a creationist to perform.

Creationism Refuted - Biologists Observe Real-Time Evolution Over 30 Years.

Two ecotypes of Littorina saxatilis marine snails,
adapted to different environments.
The Crab ecotype (left) is larger and wary of predators.
The Wave ecotype (right) is smaller and has bold behavior.

© David Carmelet

ISTA | Evolution in Real Time

In a devastating rebuttal of creationists’ assertions that evolution has never been observed, a team led by the Austrian Institute of Science and Technology (ISTA) have just published the results of a 30-year study which records the evolution of a marine snail.

The normal response of creationists to this sort of observation is a desperate attempt to redefine evolution as something other than the scientific one of change in allele frequency over time in a population to one of their cult's childish parodies - cats turning into dogs; monkeys having human babies, etc.; or bleating forlornly about 'Macro- evolution'.

The fact remain, however, that science isn't going to change its definition to suit creationists so they can continue to misrepresent it to their credulous dupes.

Evolution happens, has been observed happening, and happens just as the Theory of Evolution predicts - in response to environmental change as environmental selectors favour some variants or combinations of variants over others, causing sorting of alleles in the population according to their differential ability to be passed down the generations into descendants.

Refuting Creationism - Humans Were Using Fire In Southeast Asia 42,000 Years Before 'Creation Week'

Access to T3 (lit area)

Photograph: V.C. Hernandez.

Fossils and fires: insights into early modern human activity in the jungles of Southeast Asia – News

At the same time that creationists believe their small god was making a universe consisting of a small flat planet with a dome over it in the Middle East, then magicking a man a d a woman without ancestors, real humans were living in the jungles of Southeast Asia and making camp fires, around which they were probably making up origin myths just like the Middle Eastern Bronze Age pastoralists did. The difference was, their myths didn't get written down and included in a book declared to be the inerrant word of a magic man in the sky, so they aren't available to fool gullible people with today.

Instead, they left tangible records of their activities that scientists are now discovering and dating to between 52,000 and 10,000 years ago; records moreover that if the campfire tales of the Middle East had any truth in them would have been swept away and destroyed or covered with a deep layer of silt containing the bodies and remains of the animals and plants destroyed in the mythical global genocidal flood inflicted on the planet by an irascible magic despot.

Ironically, the human remains found buried in sediment in a cave floor were probably washed into the cave by a local flood, so all the other fossils at that location are also of local species, not the world-wide jumble that a global flood would have produced.

Tell me about the prehistoric history of the humans who occupied the Tam Pà Ling cave in Laos, please. The Tam Pà Ling cave, located in northern Laos, has yielded some of the most significant prehistoric human remains in Southeast Asia, providing key insights into the early human migrations in the region. The cave, whose name means "Cave of the Monkeys," sits at around 1,170 meters above sea level in the Annamite Mountains, making it an ideal site for shelter during prehistoric times.

Key Findings and Human Occupation
The site became famous when researchers unearthed several human fossils, including a cranium and jawbones, that have been radiocarbon dated between 46,000 and 63,000 years ago. These discoveries suggest that anatomically modern humans (*Homo sapiens*) were present in Southeast Asia much earlier than previously believed. The remains from Tam Pà Ling are considered some of the oldest evidence of modern humans in mainland Asia.

Significance in Human Migration
The fossils found in Tam Pà Ling have played an essential role in understanding the "Out of Africa" migration, where *Homo sapiens* spread from Africa to the rest of the world. The cave’s location, relatively close to the Mekong River, is thought to have been part of a corridor that early humans used as they moved from Africa through the Middle East, into South Asia, and ultimately into Southeast Asia and Australia.

The discovery of such early modern human remains in Laos supports the theory that early humans reached Southeast Asia via inland routes, rather than following only coastal paths. This inland route theory aligns with the ecological diversity of the region, which would have provided rich resources for early hunter-gatherer groups.

Anatomical Evidence
The fossils found in Tam Pà Ling are distinctly modern in their features. The skulls exhibit traits that are fully consistent with *Homo sapiens*, such as a high forehead, rounded braincase, and small, flat faces. However, some subtle characteristics, like thicker bones and robustness, indicate potential regional adaptations or the influence of archaic hominins like *Homo erectus* or *Denisovans*, both of whom were known to have existed in the broader region.

Cultural Context
No significant cultural artifacts, such as tools or other evidence of complex human behavior, have been found alongside the fossils in Tam Pà Ling, which leaves some aspects of the lives of these early inhabitants uncertain. Nonetheless, their presence in the cave hints at how early humans adapted to diverse environments—ranging from highland caves like Tam Pà Ling to coastal areas.

Importance in the Global Human Evolution Story
The discovery of these early human remains in Tam Pà Ling has contributed to the global conversation on human evolution. It suggests that *Homo sapiens* coexisted with archaic hominins in Asia longer than once thought. It also challenges the idea that humans primarily spread through coastal routes, indicating that Southeast Asia was likely populated by multiple waves of migration, using both coastal and inland routes.

The Tam Pà Ling site remains an important location for understanding the complexity of early human migration and the spread of *Homo sapiens* across the globe.

The cave is the Tam Pà Ling cave, located in northern Laos where Laotian, French, American and Australian archaeologists have been working for some 14 years to unearth the secrets contained in it.

Now a new study, led by PhD candidate Vito Hernandez and Associate Professor Mike Morley from the College of Humanities, Arts and Social Sciences at Flinders University, SA, Australia, has reconstructed the ground conditions inside the cave between 52,000 and 10,000 years ago. They have just published their findings in Quaternary Science Reviews and announced them in a Flinders University news release:

Fossils and fires: insights into early modern human activity in the jungles of Southeast Asia

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Studying microscopic layers of dirt dug from the Tam Pà Ling cave site in northeastern Laos has provided a team of Flinders University archaeologists and their international colleagues further insights into some of the earliest evidence of Homo sapiens in mainland Southeast Asia.

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The site, which has been studied for the past 14 years by a team of Laotian, French, American and Australian scientists, has produced some of the earliest fossil evidence of our direct ancestors in Southeast Asia.

Excavation of the Tam Pà Ling cave

Now a new study, led by PhD candidate Vito Hernandez and Associate Professor Mike Morley from the College of Humanities, Arts and Social Sciences, has reconstructed the ground conditions in the cave between 52,000 and 10,000 years ago.

Using a technique known as microstratigraphy at the Flinders Microarchaeology Laboratory, we were able to reconstruct the cave conditions in the past and identify traces of human activities in and around Tam Pà Ling. This also helped us to determine the precise circumstances by which some of the earliest modern human fossils found in Southeast Asia were deposited deep inside.

Vito C Hernandez, co-lead author
Flinders Microarchaeology Laboratory
College of Humanities, Arts and Social Sciences
Flinders University, South Australia, Australia.

Microstratigraphy allows scientists to study dirt in its smallest detail, enabling them to observe structures and features that preserve information about past environments and even traces of human and animal activity that may have been overlooked during the excavation process due to their minuscule size.

The human fossils discovered at Tam Pà Ling were deposited in the cave between 86,000–30,000 years ago but until now, researchers had not conducted a detailed analysis of the sediments surrounding these fossils to gain an understanding of how they were deposited in the cave or the environmental conditions at the time.

Published in Quaternary Science Reviews, the findings reveal conditions in the cave fluctuated dramatically, going from a temperate climate with frequent wet ground conditions to becoming seasonally dry.

This change in environment influenced the cave’s interior topography and would have impacted how sediments, including human fossils, were deposited within the cave. How early Homo sapiens came to be buried deep within the cave has long been debated, but our sediment analysis indicates that the fossils were washed into the cave as loose sediments and debris accumulating over time, likely carried by water from surrounding hillsides during periods of heavy rainfall.

Associate Professor ,” says Associate Professor W.M. Morley, co-lead author
Flinders Microarchaeology Laboratory
College of Humanities, Arts and Social Sciences
Flinders University, South Australia, Australia.

The team also identified preserved micro-traces of charcoal and ash in the cave sediments, suggesting that either forest fires occurred in the region during the drier periods, or that humans visiting the cave may have used fire, either in the cave or near the entrance.

This research has allowed our team to develop unprecedented insights into the dynamics of our ancestors as they dispersed through the ever-changing forest covers of Southeast Asia, and during periods of variable regional climate instability.

,Assistant Professor Fabrice Demeter, co-author
Lundbeck Foundation GeoGenetics Centre
Globe Institute
University of Copenhagen, Copenhagen, Denmark.

Publication:

VC Hernandez, MW Morley, AM Bacon, P Duringer, KE Westaway, R Joannes-Boyau, JL Ponche, C Zanolli, P Sichanthongtip, S Boualaphane, T Luangkhoth, JJ Hublin, F Demeter
Late Pleistocene–Holocene (52–10 ka) microstratigraphy, fossil taphonomy and depositional environments from Tam Pa Ling cave (northeastern Laos) Quaternary Science Reviews (2024) 108982. DOI: 10.1016/j.quascirev.2024.108982

Highlights

• Late Pleistocene-Holocene cave sediments from Tam Pà Ling, northeastern Laos, were geoarchaeologically investigated.
• Microstratigraphic analyses were employed.
• Ground and ambient conditions vary in the cave ∼52–10 ka.

Abstract
Fossil evidence for some of the earliest Homo sapiens presence in mainland Southeast Asia have been recovered from Tam Pà Ling (TPL) cave, northeastern Laos. Taphonomic indicators suggest that these human fossils washed into TPL via gradual colluviation at varying times between MIS 5–3, yet no attempt has been made to situate them within the depositional environments of the cave within these periods. This has precluded a deeper appreciation of their presence there and in the surrounding landscape. In this first microstratigraphic study of TPL, we primarily use sediment micromorphology to reconstruct the depositional environments of the cave, relate these environments with the taphonomic history of the human fossils recovered from the upper 4 m of the excavated sequence, and explore how the sediments can better explain the presence of these humans in the area during MIS 3–1 (52–10 ka). Our results demonstrate changes in local ambient conditions from being temperate to arid, with ground conditions often wet during MIS 3 and becoming increasingly seasonal (wet-dry) during MIS 2–1. The changing cave conditions impacted its interior topography and influenced the way sediments (and fossils) were deposited. Preserved combustion biproducts identified in the sediments suggest two possible scenarios, one where small forest fires may have occurred during periods of regional aridity and/or another where humans visited the cave.

1. Introduction
The excavations in Tam Pà Ling (Cave of Monkeys), northeastern Laos (Fig. 1A), have unearthed a fossil assemblage of Homo sapiens that is unique for the study of Late Pleistocene human evolution in Southeast Asia (SEA) (Demeter et al., 2012; Demeter et al., 2015; Demeter et al., 2017; Shackelford et al., 2018; Freidline et al., 2023). The fossil assemblage is formed of a partial cranium (TPL1), two mandibles (TPL2, TPL3), a partial rib (TPL4), a proximal pedal phalanx (TPL5), a partial frontal (TPL6), and a tibial fragment (TPL7), all excavated from a trench situated deep inside the cave. Although disarticulated, the fossils otherwise display minimal evidence of remobilisation or physical abrasion, a rare occurrence from the region (Lee and Hudock, 2021; Sawafuji et al., 2024). As such, the fossils have helped demonstrate the major morphological variations that existed between the different populations of Homo sapiens in SEA during the Late Pleistocene (Demeter et al., 2017), consequently making Tam Pà Ling (TPL) a key site for the study of the evolution and dispersal of our species in the Far East (Matsumura et al., 2019; Demeter and Bae, 2020; Hublin, 2021.1; McAllister et al., 2022; Sawafuji et al., 2024).

Fig. 1. (A) Location of Tam Pà Ling (20°12′33.41"N, 103°24′22.02"E). Red square indicates the study area. (B) Pà Hang hill with Tam Pà Ling and other studied sites labelled (Photograph: P. Duringer) (C) Access to T3 (lit area) (Photograph: V.C. Hernandez). (D) Plan of Tam Pà Ling (Redrawn after J.-L. Ponche and P. Duringer). (E) Studied section showing locations of micromorphological sampling and levels where TPL1, 2, and 5 were recovered (dashed orange line)

Photograph V.C. Hernandez.

The TPL fossils represent some of the earliest evidence for Homo sapiens in continental SEA, deposited in the cave at different times between Marine Isotope Stage (MIS) 5b and MIS 3 (∼87–30 ka) (Freidline et al., 2023). Although some of the fossils have been directly dated via uranium–thorium methods, their dates are reported only as minimum age estimates (Demeter et al., 2012, 2015). This is largely due to the unaccounted profiles of uranium from the sampled deposits, noting that tropical environments hold the potential of enhancing heterogeneous distribution of uranium in bones that are chemically weathered in situ. Hence, the modelled depositional ages (2σ) of the containing sediment matrix are preferred when referring to the age of the fossils, with the oldest returned age estimate being ∼86 ka, supporting a much earlier dispersal of Homo sapiens into SEA than previously known. Details of the modelled depositional chronology of TPL are published in Freidline et al. (2023). Whereas palaeoenvironmental reconstructions of the landscape surrounding TPL have provided some context to understand the early dispersal of Homo sapiens in SEA (Milano et al., 2018.1; Bourgon et al., 2021.2; McAllister-Hayward et al., 2024.1), there is still very little understanding of their presence at the site and in the local catchment, other than the occurrence of the fossils. This largely precludes the development of more detailed scenarios for the early Homo sapiens settlement of Asia (Dennell, 2017.1) and achieving a better understanding of their adaptations to environmental changes in tropical landscapes, which are argued to play an important role in human evolution and dispersals in the deep past (Scerri et al., 2022.1 and references therein). In SEA, such knowledge remains elusive due to the limited evidence from the Pleistocene archaeological record and the current resolution of ages that frame the presence of humans at many of the studied sites.

While the ages of the fossils from TPL are well-constrained, the absence of artefacts or occupation surfaces found to date suggests that humans did not intensively occupy the cave during the Late Pleistocene. However, evidence of human presence and occupation at neighbouring sites spanning the Middle Pleistocene to Late Holocene (Demeter et al., 2009; Patole-Edoumba, 2015.1; Bacon et al., 2021.3; Demeter et al., 2022.2, Fig. 1B), and the presence of the fossils from TPL, suggest that humans may have at least visited sporadically or used the cave in the past, even briefly. If so, then traces of their activities from the entrance or even inside might still be preserved, although likely in small quantities, probably degraded, diagenetically altered, or buried beneath limestone slabs.

The research at TPL has simultaneously highlighted the scientific challenges of understanding archaeological site formation processes in the hot and humid tropics (Morley and Goldberg, 2017.2 and references therein), and the need to better understand geomorphological processes that affect the interpretation and dating of fossils from cave sites (Liu et al., 2015.2; Westaway et al., 2017.3; Yao et al., 2020.1). These challenges are made more difficult by the erratic preservation of organic materials in tropical cave environments (Louys et al., 2017.4 and references therein; Smith et al., 2020.2 and references therein), and therefore demand the systematic evaluation of the stratigraphy of a site with the potential to yield bioarchaeological data (e.g., aDNA, proteins) that can inform about humans and their environments in the past (Massilani et al., 2022.3; Morley et al., 2023.1; Aldeias and Stahlschmidt, 2024.2). It is for these reasons that there is a need to better understand the stratigraphy of TPL at various spatial scales (vertical and horizontal) and at finer resolution, with research from other sites in SEA suggesting a geoarchaeology-focused approach to achieve this (O'Connor et al., 2010; Morley, 2017.5).

Sediment micromorphology (microstratigraphy) is one method employed in geoarchaeological research that can help to better understand the geomorphological and site formation processes governing TPL. Research employing this method to study the critical sites for understanding early human evolution and dispersals in SEA show that microstratigraphy can provide a more nuanced picture of local environments in the past, help to reveal more about human adaptations to the different environmental conditions that existed, and temporally resolve the presence of humans on-site and in the immediate catchment (Stephens et al., 2005, 2017.6; Lewis, 2007; Brasseur et al., 2015.3; Mijares, 2017.7; Morley et al., 2017.8; McAdams et al., 2020.3; Anderson et al., 2024.3; Shipton et al., 2024.4). With these in mind, a program of microstratigraphic analysis at TPL was initiated to gain further insights into the history of the site and the taphonomy of the Homo sapiens fossils recovered from there.

To improve the understanding of the history of the site and taphonomy of Homo sapiens fossils recovered from TPL we link the results of the microstratigraphic analysis with loss-on-ignition (LOI) and magnetic susceptibility (χ) analysis of sediments. Both methods provide quick to obtain and accurate determinations of geochemical characteristics that can complement the interpretation of the microstratigraphic record (Stoops, 1978; Macphail and Goldberg, 2017.9). LOI, for instance, has complemented microstratigraphic analysis of archaeological cave sites in Malaysia, northern Vietnam and Thailand, resulting in a clearer understanding of the depositional environments that existed in these caves in the past (Hunt et al., 2007.1; Stephens et al., 2016; McAdams et al., 2020.3; Saminpanya and Denkitkul, 2020.4). While χ has been used at TPL to infer moisture availability that helped to reconstruct the vegetation surrounding the cave during the Late Pleistocene (Milano et al., 2018.1) and allowed insights into the timing of sediment delivery into the cave during periods of strengthened monsoons (Freidline et al., 2023). By linking the results of these analyses with that of the microstratigraphy, it is hoped that a clearer understanding of site formation and better explanation of the presence of humans at TPL is achieved.

Here, we present the results of the program to analyse the microstratigraphy, LOI and χ of sediments in TPL. Our geoarchaeological work aims to prove the efficacy of a microstratigraphic approach to understanding the important stratigraphy of the site by reconstructing its ground conditions, clarifying the taphonomic history of the fossils related to the depositional history of the cave, and exploring the potential archaeology within its sediments. By doing so, we try to resolve how past conditions in TPL (sediment, cave, and catchment) affect the interpretation of human presence at the site and explore how this information changes the narrative of Late Pleistocene human evolution and dispersals in the Far East. We focus the analyses on the upper 4 m Late Pleistocene–Holocene sediment sequence exposed in the 7 m-deep excavation inside the cave. This upper sequence was securely dated to between 46 ± 6 ka and 13 ± 3 ka (Freidline et al., 2023) and was where the human fossils TPL1, 2 and 5 were recovered (Demeter et al., 2012, Demeter et al., 2015, Demeter et al., 2017).

The refutation of creationism continues unabated. Not only were there people living in South East Asia tens of thousands of years before creationists think Earth was created by magic, but the remains proving it were washed into the cave by a local flood, which, had it been anything resembling creationism's favourite genocidal flood, would also have washed in non-local debris. And that simply never happened, then or later.

And, to make it doubly difficult for creationists to explain without the usual lies and misrepresentations of the dating methods used, the authors have allowed for possible errors by using the minimum ages of the fossils. In other words, if creationists are right about errors in the dating methods, these fossils are even older than creationists dogma says they should be.

And so creationism staggers on under the load of yet more evidence that it is just a childish fairytale.

Refuting Creationism - Even More Signs of The Divine Malevolence's Obsessive Compulsive Disorder?

AI-generated image (ChatGPT4o)

Over 160,000 new virus species discovered by AI - The University of Sydney

This is the second paper today to show the apparent obsession creationism's putative designer has with creating viruses, if you believe that superstition.

The first paper dealt with the discovery that there are some 600 different viruses to be found on a used toothbrush and on the shower heads in US bathrooms; this one reports on a discovery that makes that finding pale into insignificance. It is the discovery, using the machine learning of AI, of 161,979 new viruses!

This is just tip of the iceberg as the authors say the method just scratches the surface of biodiversity and opens up a world of discovery with millions more to be discovered.

Refuting Creationism - Is Creationism's Divine Malevolence Sufferring from Obsessive-Compulsive Disorder?

Northwestern microbiologists found more than 600 viruses on samples collected from used toothbrushes and shower heads.

AI-Generated graphic (ChatGPT4o)

Structural model at atomic resolution of bacteriophage T4

By Dr. Victor Padilla-Sanchez, PhD https://www.drvictorpadillasanchez.com
Own work, CC BY-SA 4.0, Link

Viruses are teeming on your toothbrush, showerhead - Northwestern Now

Creationism's putative creator is nothing if not obsessive.

One of its obsessions appears to be designing ever-more exquisite ways to kill its creation as almost nothing in nature exists that doesn't have something that lives on or in it, often killing it in the process or at least weakening it in some way.

Its most visible obsession seems to be with designing beetles of which there are some 500,000 species with more being discovered almost daily. It's highly likely that there may be as many as a million different beetles in the world, many of which catch and devour other arthropods.

But it's in the field of virology that we find another obsession with designing variations on a general theme. Not only are there literally hundreds of thousands of viruses but every species has multiple variants - look at the number of different variants of the SARS-CoV-2 virus that have emerged since the initial wave of the COVID-19 pandemic!